| Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases M Zhuang, MF Calabrese, J Liu, MB Waddell, A Nourse, M Hammel, ... Molecular cell 36 (1), 39-50, 2009 | 475 | 2009 |
| Basis for a ubiquitin-like protein thioester switch toggling E1–E2 affinity DT Huang, HW Hunt, M Zhuang, MD Ohi, JM Holton, BA Schulman Nature 445 (7126), 394-398, 2007 | 273 | 2007 |
| Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1 DT Huang, A Paydar, M Zhuang, MB Waddell, JM Holton, BA Schulman Molecular cell 17 (3), 341-350, 2005 | 232 | 2005 |
| SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer G Li, W Ci, S Karmakar, K Chen, R Dhar, Z Fan, Z Guo, J Zhang, Y Ke, ... Cancer cell 25 (4), 455-468, 2014 | 177 | 2014 |
| A proximity-tagging system to identify membrane protein–protein interactions Q Liu, J Zheng, W Sun, Y Huo, L Zhang, P Hao, H Wang, M Zhuang Nature methods 15 (9), 715-722, 2018 | 174 | 2018 |
| The DegraBase: a database of proteolysis in healthy and apoptotic human cells ED Crawford, JE Seaman, N Agard, GW Hsu, O Julien, S Mahrus, ... Molecular & Cellular Proteomics 12 (3), 813-824, 2013 | 152 | 2013 |
| Substrates of IAP ubiquitin ligases identified with a designed orthogonal E3 ligase, the NEDDylator M Zhuang, S Guan, H Wang, AL Burlingame, JA Wells Molecular cell 49 (2), 273-282, 2013 | 128 | 2013 |
| Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles O Julien, M Zhuang, AP Wiita, AJ O’Donoghue, GM Knudsen, CS Craik, ... Proceedings of the National Academy of Sciences 113 (14), E2001-E2010, 2016 | 113 | 2016 |
| ERdj3, a Luminal ER DnaJ Homologue, Binds Directly to Unfolded Proteins in the Mammalian ER: Identification of Critical Residues† Y Jin, M Zhuang, LM Hendershot Biochemistry 48 (1), 41-49, 2008 | 85 | 2008 |
| Capturing RNA–protein interaction via CRUIS Z Zhang, W Sun, T Shi, P Lu, M Zhuang, JL Liu Nucleic acids research 48 (9), e52-e52, 2020 | 62 | 2020 |
| Identification of conjugation specificity determinants unmasks vestigial preference for ubiquitin within the NEDD8 E2 DT Huang, M Zhuang, O Ayrault, BA Schulman Nature structural & molecular biology 15 (3), 280-287, 2008 | 62 | 2008 |
| TALEN-based generation of a cynomolgus monkey disease model for human microcephaly Q Ke, W Li, X Lai, H Chen, L Huang, Z Kang, K Li, J Ren, X Lin, H Zheng, ... Cell Research 26 (9), 1048-1061, 2016 | 50 | 2016 |
| APOBEC3 induces mutations during repair of CRISPR–Cas9-generated DNA breaks L Lei, H Chen, W Xue, B Yang, B Hu, J Wei, L Wang, Y Cui, W Li, J Wang, ... Nature Structural & Molecular Biology 25 (1), 45-52, 2018 | 48 | 2018 |
| Heat shock protein 70 (Hsp70) suppresses RIP1-dependent apoptotic and necroptotic cascades SR Srinivasan, LC Cesa, X Li, O Julien, M Zhuang, H Shao, J Chung, ... Molecular cancer research 16 (1), 58-68, 2018 | 48 | 2018 |
| Direct proximity tagging of small molecule protein targets using an engineered NEDD8 ligase ZB Hill, SB Pollock, M Zhuang, JA Wells Journal of the American Chemical Society 138 (40), 13123-13126, 2016 | 40 | 2016 |
| Ubiquitin ligase MARCH5 localizes to peroxisomes to regulate pexophagy J Zheng, X Chen, Q Liu, G Zhong, M Zhuang Journal of Cell Biology 221 (1), e202103156, 2021 | 32 | 2021 |
| Protein tyrosine phosphatase receptor type R (PTPRR) antagonizes the Wnt signaling pathway in ovarian cancer by dephosphorylating and inactivating β-catenin Y Wang, J Cao, W Liu, J Zhang, Z Wang, Y Zhang, L Hou, S Chen, P Hao, ... Journal of Biological Chemistry 294 (48), 18306-18323, 2019 | 21 | 2019 |
| An activation-induced IL-15 isoform is a natural antagonist for IL-15 function L Zhao, B Hu, Y Zhang, Y Song, D Lin, Y Liu, Y Mei, D Sandikin, W Sun, ... Scientific reports 6 (1), 25822, 2016 | 17 | 2016 |
| The MFN1 and MFN2 mitofusins promote clustering between mitochondria and peroxisomes Y Huo, W Sun, T Shi, S Gao, M Zhuang Communications Biology 5 (1), 423, 2022 | 15 | 2022 |
| FER-mediated phosphorylation and PIK3R2 recruitment on IRS4 promotes AKT activation and tumorigenesis in ovarian cancer cells Y Zhang, X Xiong, Q Zhu, J Zhang, S Chen, Y Wang, J Cao, L Chen, ... Elife 11, e76183, 2022 | 12 | 2022 |
James A. WellsUniversity of California, San FranciscoVerified email at ucsf.edu
