Satoshi Okada
Satoshi Okada
Professor, Department of Pediatrics, Hiroshima University
Verified email at - Homepage
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Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis
L Liu, S Okada, XF Kong, AY Kreins, S Cypowyj, A Abhyankar, J Toubiana, ...
Journal of Experimental Medicine 208 (8), 1635-1648, 2011
Mycobacterial disease and impaired IFN-γ immunity in humans with inherited ISG15 deficiency
D Bogunovic, M Byun, LA Durfee, A Abhyankar, O Sanal, D Mansouri, ...
Science 337 (6102), 1684-1688, 2012
Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation
X Zhang, D Bogunovic, B Payelle-Brogard, V Francois-Newton, SD Speer, ...
Nature 517 (7532), 89-93, 2015
Heterozygous STAT1 gain-of-function mutations underlie an unexpectedly broad clinical phenotype
J Toubiana, S Okada, J Hiller, M Oleastro, M Lagos Gomez, ...
Blood, The Journal of the American Society of Hematology 127 (25), 3154-3164, 2016
Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency
MJ Ciancanelli, SXL Huang, P Luthra, H Garner, Y Itan, S Volpi, ...
Science 348 (6233), 448-453, 2015
Autoantibodies neutralizing type I IFNs are present in~ 4% of uninfected individuals over 70 years old and account for~ 20% of COVID-19 deaths
P Bastard, A Gervais, T Le Voyer, J Rosain, Q Philippot, J Manry, ...
Science immunology 6 (62), eabl4340, 2021
Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations
S Okada, JG Markle, EK Deenick, F Mele, D Averbuch, M Lagos, ...
Science 349 (6248), 606-613, 2015
Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4–insufficient subjects
C Schwab, A Gabrysch, P Olbrich, V Patińo, K Warnatz, D Wolff, ...
Journal of Allergy and Clinical Immunology 142 (6), 1932-1946, 2018
X-linked recessive TLR7 deficiency in~ 1% of men under 60 years old with life-threatening COVID-19
T Asano, B Boisson, F Onodi, D Matuozzo, M Moncada-Velez, ...
Science immunology 6 (62), eabl4348, 2021
Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome
AY Kreins, MJ Ciancanelli, S Okada, XF Kong, N Ramírez-Alejo, SS Kilic, ...
Journal of Experimental Medicine 212 (10), 1641-1662, 2015
Inborn errors of human STAT1: allelic heterogeneity governs the diversity of immunological and infectious phenotypes
S Boisson-Dupuis, XF Kong, S Okada, S Cypowyj, A Puel, L Abel, ...
Current opinion in immunology 24 (4), 364-378, 2012
A global effort to define the human genetics of protective immunity to SARS-CoV-2 infection
JL Casanova, HC Su, L Abel, A Aiuti, S Almuhsen, AA Arias, P Bastard, ...
Cell 181 (6), 1194-1199, 2020
Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies
CS Ma, N Wong, G Rao, DT Avery, J Torpy, T Hambridge, J Bustamante, ...
Journal of Allergy and Clinical Immunology 136 (4), 993-1006. e1, 2015
DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice
KL Randall, SSY Chan, CS Ma, I Fung, Y Mei, M Yabas, A Tan, ...
Journal of Experimental Medicine 208 (11), 2305-2320, 2011
Inherited DOCK2 deficiency in patients with early-onset invasive infections
K Dobbs, C Domínguez Conde, SY Zhang, S Parolini, M Audry, J Chou, ...
New England Journal of Medicine 372 (25), 2409-2422, 2015
Mendelian susceptibility to mycobacterial disease: 2014–2018 update
J Rosain, XF Kong, R Martinez‐Barricarte, C Oleaga‐Quintas, ...
Immunology and cell biology 97 (4), 360-367, 2019
Human IFN-γ immunity to mycobacteria is governed by both IL-12 and IL-23
R Martínez-Barricarte, JG Markle, CS Ma, EK Deenick, N Ramírez-Alejo, ...
Science immunology 3 (30), eaau6759, 2018
Chronic mucocutaneous candidiasis disease associated with inborn errors of IL‐17 immunity
S Okada, A Puel, JL Casanova, M Kobayashi
Clinical & translational immunology 5 (12), e114, 2016
Genetic, immunological, and clinical features of patients with bacterial and fungal infections due to inherited IL-17RA deficiency
R Lévy, S Okada, V Béziat, K Moriya, C Liu, LYA Chai, M Migaud, F Hauck, ...
Proceedings of the National Academy of Sciences 113 (51), E8277-E8285, 2016
Hematopoietic stem cell transplantation in patients with gain-of-function signal transducer and activator of transcription 1 mutations
JW Leiding, S Okada, D Hagin, M Abinun, A Shcherbina, DN Balashov, ...
Journal of Allergy and Clinical Immunology 141 (2), 704-717. e5, 2018
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