Srikumar Chellappan
Srikumar Chellappan
Senior Member and Chair, Moffitt Cancer Center
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The E2F transcription factor is a cellular target for the RB protein
SP Chellappan, S Hiebert, M Mudryj, JM Horowitz, JR Nevins
Cell 65 (6), 1053-1061, 1991
Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the …
S Chellappan, VB Kraus, B Kroger, K Munger, PM Howley, WC Phelps, ...
Proceedings of the National Academy of Sciences 89 (10), 4549-4553, 1992
The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F.
SW Hiebert, SP Chellappan, JM Horowitz, JR Nevins
Genes & development 6 (2), 177-185, 1992
Prohibitin induces the transcriptional activity of p53 and is exported from the nucleus upon apoptotic signaling
G Fusaro, P Dasgupta, S Rastogi, B Joshi, S Chellappan
Journal of Biological Chemistry 278 (48), 47853-47861, 2003
Nicotine induces cell proliferation, invasion and epithelial‐mesenchymal transition in a variety of human cancer cell lines
P Dasgupta, W Rizwani, S Pillai, R Kinkade, M Kovacs, S Rastogi, ...
International Journal of Cancer 124 (1), 36-45, 2009
Nicotine inhibits apoptosis induced by chemotherapeutic drugs by up-regulating XIAP and survivin
P Dasgupta, R Kinkade, B Joshi, C DeCook, E Haura, S Chellappan
Proceedings of the National Academy of Sciences 103 (16), 6332-6337, 2006
Nicotine induces cell proliferation by β-arrestin–mediated activation of Src and Rb–Raf-1 pathways
P Dasgupta, S Rastogi, S Pillai, D Ordonez-Ercan, M Morris, E Haura, ...
The Journal of clinical investigation 116 (8), 2208-2217, 2006
Nicotine-mediated cell proliferation and tumor progression in smoking-related cancers
C Schaal, SP Chellappan
Molecular Cancer Research 12 (1), 14-23, 2014
Interactions of the p107 and Rb proteins with E2F during the cell proliferation response.
JK Schwarz, SH Devoto, EJ Smith, SP Chellappan, L Jakoi, JR Nevins
The EMBO journal 12 (3), 1013-1020, 1993
Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function
S Wang, N Nath, M Adlam, S Chellappan
Oncogene 18 (23), 3501-3510, 1999
Prohibitin co-localizes with Rb in the nucleus and recruits N-CoR and HDAC1 for transcriptional repression
S Wang, G Fusaro, J Padmanabhan, SP Chellappan
Oncogene 21 (55), 8388-8396, 2002
EGFR/Src/Akt signaling modulates Sox2 expression and self-renewal of stem-like side-population cells in non-small cell lung cancer
S Singh, J Trevino, N Bora-Singhal, D Coppola, E Haura, S Altiok, ...
Molecular cancer 11, 1-15, 2012
Nicotine promotes tumor growth and metastasis in mouse models of lung cancer
R Davis, W Rizwani, S Banerjee, M Kovacs, E Haura, D Coppola, ...
PloS one 4 (10), e7524, 2009
Rb and prohibitin target distinct regions of E2F1 for repression and respond to different upstream signals
S Wang, N Nath, G Fusaro, S Chellappan
Molecular and cellular biology 19 (11), 7447-7460, 1999
Nicotine-mediated cell proliferation and angiogenesis: new twists to an old story
P Dasgupta, SP Chellappan
Cell cycle 5 (20), 2324-2328, 2006
Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation
S Wang, RN Ghosh, SP Chellappan
Molecular and cellular biology 18 (12), 7487-7498, 1998
Glut-1 antibodies induce growth arrest and apoptosis in human cancer cell lines
S Rastogi, S Banerjee, S Chellappan, GR Simon
Cancer letters 257 (2), 244-251, 2007
YAP1 regulates OCT4 activity and SOX2 expression to facilitate self‐renewal and vascular mimicry of stem‐like cells
N Bora‐Singhal, J Nguyen, C Schaal, D Perumal, S Singh, D Coppola, ...
Stem cells 33 (6), 1705-1718, 2015
Regulation of Rb and E2F by signal transduction cascades: divergent effects of JNK1 and p38 kinases
S Wang, N Nath, A Minden, S Chellappan
The EMBO journal, 1999
Nicotinic acetylcholine receptor signaling in tumor growth and metastasis
S Singh, S Pillai, S Chellappan
Journal of oncology 2011, 2011
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