Celia A Schiffer
Celia A Schiffer
Professor and Chair of Biochemistry and Molecular Biotechnology, U Mass Chan Medical School
Verified email at umassmed.edu - Homepage
Title
Cited by
Cited by
Year
Substrate shape determines specificity of recognition for HIV-1 protease: analysis of crystal structures of six substrate complexes
M Prabu-Jeyabalan, E Nalivaika, CA Schiffer
Structure 10 (3), 369-381, 2002
3792002
Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor
DLNG Surleraux, A Tahri, WG Verschueren, GME Pille, HA De Kock, ...
Journal of medicinal chemistry 48 (6), 1813-1822, 2005
2902005
Structural and thermodynamic basis for the binding of TMC114, a next-generation human immunodeficiency virus type 1 protease inhibitor
NM King, M Prabu-Jeyabalan, EA Nalivaika, P Wigerinck, MP De Béthune, ...
Journal of virology 78 (21), 12012-12021, 2004
2852004
Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments
TD Wu, CA Schiffer, MJ Gonzales, J Taylor, R Kantor, S Chou, D Israelski, ...
Journal of virology 77 (8), 4836-4847, 2003
2742003
Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments
TD Wu, CA Schiffer, MJ Gonzales, J Taylor, R Kantor, S Chou, D Israelski, ...
Journal of virology 77 (8), 4836-4847, 2003
2742003
Curling of flap tips in HIV-1 protease as a mechanism for substrate entry and tolerance of drug resistance
WRP Scott, CA Schiffer
Structure 8 (12), 1259-1265, 2000
2482000
The molecular basis of drug resistance against hepatitis C virus NS3/4A protease inhibitors
KP Romano, A Ali, C Aydin, D Soumana, A Özen, LM Deveau, C Silver, ...
PLoS pathogens 8 (7), e1002832, 2012
2092012
Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding
KP Romano, A Ali, WE Royer, CA Schiffer
Proceedings of the National Academy of Sciences 107 (49), 20986-20991, 2010
2072010
How does a symmetric dimer recognize an asymmetric substrate? A substrate complex of HIV-1 protease
M Prabu-Jeyabalan, E Nalivaika, CA Schiffer
Journal of molecular biology 301 (5), 1207-1220, 2000
2062000
Combating susceptibility to drug resistance: lessons from HIV-1 protease
NM King, M Prabu-Jeyabalan, EA Nalivaika, CA Schiffer
Chemistry & biology 11 (10), 1333-1338, 2004
1582004
Molecular basis for drug resistance in HIV-1 protease
A Ali, RM Bandaranayake, Y Cai, NM King, M Kolli, S Mittal, JF Murzycki, ...
Viruses 2 (11), 2509-2535, 2010
1472010
Crystal structure of the APOBEC3G catalytic domain reveals potential oligomerization interfaces
SMD Shandilya, MNL Nalam, EA Nalivaika, PJ Gross, JC Valesano, ...
Structure 18 (1), 28-38, 2010
1472010
Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site
CA Schiffer, IJ Clifton, VJ Davisson, DV Santi, RM Stroud
Biochemistry 34 (50), 16279-16287, 1995
1451995
Viral protease inhibitors
J Anderson, C Schiffer, SK Lee, R Swanstrom
Antiviral strategies, 85-110, 2009
1392009
Replacement of the P1 amino acid of human immunodeficiency virus type 1 Gag processing sites can inhibit or enhance the rate of cleavage by the viral protease
SC Pettit, GJ Henderson, CA Schiffer, R Swanstrom
Journal of Virology 76 (20), 10226-10233, 2002
1342002
HIV-1 protease inhibitors from inverse design in the substrate envelope exhibit subnanomolar binding to drug-resistant variants
MD Altman, A Ali, GSK Kumar Reddy, MNL Nalam, SG Anjum, H Cao, ...
Journal of the American Chemical Society 130 (19), 6099-6113, 2008
1312008
Methylcytosine and normal cytosine deamination by the foreign DNA restriction enzyme APOBEC3A
MA Carpenter, M Li, A Rathore, L Lackey, EK Law, AM Land, B Leonard, ...
Journal of Biological Chemistry 287 (41), 34801-34808, 2012
1302012
PTEN enters the nucleus by diffusion
F Liu, S Wagner, RB Campbell, JA Nickerson, CA Schiffer, AH Ross
Journal of cellular biochemistry 96 (2), 221-234, 2005
1282005
Viability of a drug-resistant human immunodeficiency virus type 1 protease variant: structural insights for better antiviral therapy
M Prabu-Jeyabalan, EA Nalivaika, NM King, CA Schiffer
Journal of virology 77 (2), 1306-1315, 2003
1272003
Viability of a drug-resistant human immunodeficiency virus type 1 protease variant: structural insights for better antiviral therapy
M Prabu-Jeyabalan, EA Nalivaika, NM King, CA Schiffer
Journal of virology 77 (2), 1306-1315, 2003
1272003
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