Aviad Tsherniak
Aviad Tsherniak
Broad Institute of Harvard and MIT
Verified email at broad.mit.edu - Homepage
TitleCited byYear
Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome
YJ Cho, A Tsherniak, P Tamayo, S Santagata, A Ligon, H Greulich, ...
Journal of Clinical Oncology 29 (11), 1424, 2011
5612011
β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis
J Rosenbluh, D Nijhawan, AG Cox, X Li, JT Neal, EJ Schafer, TI Zack, ...
Cell 151 (7), 1457-1473, 2012
4752012
Prognostically relevant gene signatures of high-grade serous ovarian carcinoma
RGW Verhaak, P Tamayo, JY Yang, D Hubbard, H Zhang, CJ Creighton, ...
The Journal of clinical investigation 123 (1), 2012
3772012
Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer
HW Cheung, GS Cowley, BA Weir, JS Boehm, S Rusin, JA Scott, A East, ...
Proceedings of the National Academy of Sciences 108 (30), 12372-12377, 2011
3512011
Defining a cancer dependency map
A Tsherniak, F Vazquez, PG Montgomery, BA Weir, G Kryukov, ...
Cell 170 (3), 564-576. e16, 2017
3072017
Genomic copy number dictates a gene-independent cell response to CRISPR/Cas9 targeting
AJ Aguirre, RM Meyers, BA Weir, F Vazquez, CZ Zhang, U Ben-David, ...
Cancer discovery 6 (8), 914-929, 2016
2732016
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies
GS Cowley, BA Weir, F Vazquez, P Tamayo, JA Scott, S Rusin, ...
Scientific data 1, 140035, 2014
2442014
Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells
RM Meyers, JG Bryan, JM McFarland, BA Weir, AE Sizemore, H Xu, ...
Nature genetics 49 (12), 1779, 2017
2312017
SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2
KH Kim, W Kim, TP Howard, F Vazquez, A Tsherniak, JN Wu, W Wang, ...
Nature medicine 21 (12), 1491, 2015
1782015
Cancer vulnerabilities unveiled by genomic loss
D Nijhawan, TI Zack, Y Ren, MR Strickland, R Lamothe, SE Schumacher, ...
Cell 150 (4), 842-854, 2012
1592012
MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells
GV Kryukov, FH Wilson, JR Ruth, J Paulk, A Tsherniak, SE Marlow, ...
Science 351 (6278), 1214-1218, 2016
1512016
Genetic and transcriptional evolution alters cancer cell line drug response
U Ben-David, B Siranosian, G Ha, H Tang, Y Oren, K Hinohara, ...
Nature 560 (7718), 325, 2018
1302018
ATARiS: computational quantification of gene suppression phenotypes from multisample RNAi screens
DD Shao, A Tsherniak, S Gopal, BA Weir, P Tamayo, N Stransky, ...
Genome research 23 (4), 665-678, 2013
1082013
SQSTM1 is a pathogenic target of 5q copy number gains in kidney cancer
L Li, C Shen, E Nakamura, K Ando, S Signoretti, R Beroukhim, GS Cowley, ...
Cancer cell 24 (6), 738-750, 2013
942013
High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines
C Yu, AM Mannan, GM Yvone, KN Ross, YL Zhang, MA Marton, BR Taylor, ...
Nature biotechnology 34 (4), 419, 2016
652016
Predicting relapse in patients with medulloblastoma by integrating evidence from clinical and genomic features
P Tamayo, YJ Cho, A Tsherniak, H Greulich, L Ambrogio, ...
Journal of clinical oncology 29 (11), 1415, 2011
592011
Next-generation characterization of the Cancer Cell Line Encyclopedia
M Ghandi, FW Huang, J JanÚ-Valbuena, GV Kryukov, CC Lo, ...
Nature 569 (7757), 503, 2019
572019
Characterizing genomic alterations in cancer by complementary functional associations
JW Kim, OB Botvinnik, O Abudayyeh, C Birger, J Rosenbluh, Y Shrestha, ...
Nature biotechnology 34 (5), 539, 2016
552016
Analyzing system logs: A new view of what’s important
S Sabato, E Yom-Tov, A Tsherniak, S Rosset
Proceedings of the 2nd USENIX workshop on Tackling computer systems problemsá…, 2007
442007
Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma
AL Kennedy, M Vallurupalli, L Chen, B Crompton, G Cowley, F Vazquez, ...
Oncotarget 6 (30), 30178, 2015
372015
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Articles 1–20