Aviad Tsherniak
Aviad Tsherniak
Broad Institute of Harvard and MIT
Verified email at broad.mit.edu - Homepage
TitleCited byYear
Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome
YJ Cho, A Tsherniak, P Tamayo, S Santagata, A Ligon, H Greulich, ...
Journal of Clinical Oncology 29 (11), 1424, 2011
β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis
J Rosenbluh, D Nijhawan, AG Cox, X Li, JT Neal, EJ Schafer, TI Zack, ...
Cell 151 (7), 1457-1473, 2012
Prognostically relevant gene signatures of high-grade serous ovarian carcinoma
RGW Verhaak, P Tamayo, JY Yang, D Hubbard, H Zhang, CJ Creighton, ...
The Journal of clinical investigation 123 (1), 2012
Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer
HW Cheung, GS Cowley, BA Weir, JS Boehm, S Rusin, JA Scott, A East, ...
Proceedings of the National Academy of Sciences 108 (30), 12372-12377, 2011
Defining a cancer dependency map
A Tsherniak, F Vazquez, PG Montgomery, BA Weir, G Kryukov, ...
Cell 170 (3), 564-576. e16, 2017
Genomic copy number dictates a gene-independent cell response to CRISPR/Cas9 targeting
AJ Aguirre, RM Meyers, BA Weir, F Vazquez, CZ Zhang, U Ben-David, ...
Cancer discovery 6 (8), 914-929, 2016
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies
GS Cowley, BA Weir, F Vazquez, P Tamayo, JA Scott, S Rusin, ...
Scientific data 1, 140035, 2014
Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells
RM Meyers, JG Bryan, JM McFarland, BA Weir, AE Sizemore, H Xu, ...
Nature genetics 49 (12), 1779, 2017
SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2
KH Kim, W Kim, TP Howard, F Vazquez, A Tsherniak, JN Wu, W Wang, ...
Nature medicine 21 (12), 1491, 2015
Cancer vulnerabilities unveiled by genomic loss
D Nijhawan, TI Zack, Y Ren, MR Strickland, R Lamothe, SE Schumacher, ...
Cell 150 (4), 842-854, 2012
MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells
GV Kryukov, FH Wilson, JR Ruth, J Paulk, A Tsherniak, SE Marlow, ...
Science 351 (6278), 1214-1218, 2016
Genetic and transcriptional evolution alters cancer cell line drug response
U Ben-David, B Siranosian, G Ha, H Tang, Y Oren, K Hinohara, ...
Nature 560 (7718), 325, 2018
ATARiS: computational quantification of gene suppression phenotypes from multisample RNAi screens
DD Shao, A Tsherniak, S Gopal, BA Weir, P Tamayo, N Stransky, ...
Genome research 23 (4), 665-678, 2013
SQSTM1 is a pathogenic target of 5q copy number gains in kidney cancer
L Li, C Shen, E Nakamura, K Ando, S Signoretti, R Beroukhim, GS Cowley, ...
Cancer cell 24 (6), 738-750, 2013
High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines
C Yu, AM Mannan, GM Yvone, KN Ross, YL Zhang, MA Marton, BR Taylor, ...
Nature biotechnology 34 (4), 419, 2016
Predicting relapse in patients with medulloblastoma by integrating evidence from clinical and genomic features
P Tamayo, YJ Cho, A Tsherniak, H Greulich, L Ambrogio, ...
Journal of clinical oncology 29 (11), 1415, 2011
Next-generation characterization of the Cancer Cell Line Encyclopedia
M Ghandi, FW Huang, J JanÚ-Valbuena, GV Kryukov, CC Lo, ...
Nature 569 (7757), 503, 2019
Characterizing genomic alterations in cancer by complementary functional associations
JW Kim, OB Botvinnik, O Abudayyeh, C Birger, J Rosenbluh, Y Shrestha, ...
Nature biotechnology 34 (5), 539, 2016
Analyzing system logs: A new view of what’s important
S Sabato, E Yom-Tov, A Tsherniak, S Rosset
Proceedings of the 2nd USENIX workshop on Tackling computer systems problemsá…, 2007
Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma
AL Kennedy, M Vallurupalli, L Chen, B Crompton, G Cowley, F Vazquez, ...
Oncotarget 6 (30), 30178, 2015
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Articles 1–20