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Rajesh Gumpena
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Identification, biochemical and structural evaluation of species-specific inhibitors against type I methionine aminopeptidases
C Kishor, T Arya, R Reddi, X Chen, V Saddanapu, AK Marapaka, ...
Journal of medicinal chemistry 56 (13), 5295-5305, 2013
332013
Identification of the molecular basis of inhibitor selectivity between the human and streptococcal type I methionine aminopeptidases
T Arya, R Reddi, C Kishor, RJ Ganji, S Bhukya, R Gumpena, S McGowan, ...
Journal of medicinal chemistry 58 (5), 2350-2357, 2015
242015
Structural studies of Enterococcus faecalis methionine aminopeptidase and design of microbe specific 2, 2′-bipyridine based inhibitors
C Kishor, R Gumpena, R Reddi, A Addlagatta
MedChemComm 3 (11), 1406-1412, 2012
222012
Structural basis for the inhibition of M1 family aminopeptidases by the natural product actinonin: Crystal structure in complex with E. coli aminopeptidase N
RJ Ganji, R Reddi, R Gumpena, AK Marapaka, T Arya, P Sankoju, ...
Protein Science 24 (5), 823-831, 2015
192015
Glu121‐Lys319 salt bridge between catalytic and N‐terminal domains is pivotal for the activity and stability of Escherichia coli aminopeptidase N
R Gumpena, C Kishor, RJ Ganji, N Jain, A Addlagatta
Protein science 21 (5), 727-736, 2012
192012
Selective targeting of the conserved active site cysteine of Mycobacterium tuberculosis methionine aminopeptidase with electrophilic reagents
R Reddi, T Arya, C Kishor, R Gumpena, RJ Ganji, S Bhukya, A Addlagatta
The FEBS Journal 281 (18), 4240-4248, 2014
142014
Discovery of α, β‐and α, γ‐Diamino Acid Scaffolds for the Inhibition of M1 Family Aminopeptidases
R Gumpena, C Kishor, RJ Ganji, A Addlagatta
ChemMedChem 6 (11), 1971-1976, 2011
142011
Dual glycolate oxidase/lactate dehydrogenase A inhibitors for primary hyperoxaluria
J Ding, R Gumpena, MO Boily, A Caron, O Chong, JH Cox, V Dumais, ...
ACS Medicinal Chemistry Letters 12 (7), 1116-1123, 2021
132021
Specificity of human sulfiredoxin for reductant and peroxiredoxin oligomeric state
TE Forshaw, JA Reisz, KJ Nelson, R Gumpena, JR Lawson, TJ Jönsson, ...
Antioxidants 10 (6), 946, 2021
112021
Crystal structure of the human dual specificity phosphatase 1 catalytic domain
R Gumpena, GT Lountos, S Raran‐Kurussi, JE Tropea, S Cherry, ...
Protein Science 27 (2), 561-567, 2018
112018
MBP-binding DARPins facilitate the crystallization of an MBP fusion protein
R Gumpena, GT Lountos, DS Waugh
Acta Crystallographica Section F: Structural Biology Communications 74 (9 …, 2018
72018
Discovery, structural and biochemical studies of a rare Glu/Asp specific M1 class aminopeptidase from Legionella pneumophila
AK Marapaka, V Pillalamarri, R Gumpena, N Haque, SC Bala, A Jangam, ...
International journal of biological macromolecules 120, 1111-1118, 2018
62018
Small Molecule TREX1 Inhibitors as Novel Immunotherapies
W Hemphill, S Harvey, R Gumpena, S Simpson, J Grayson, T Smalley, ...
The FASEB Journal 34 (S1), 1-1, 2020
52020
Crystal structure of UDP-glucose pyrophosphorylase from Yersinia pestis, a potential therapeutic target against plague
ME Gibbs, GT Lountos, R Gumpena, DS Waugh
Acta Crystallographica Section F: Structural Biology Communications 75 (9 …, 2019
52019
Study of quinoxaline-based new compounds against aminopeptidase N, and Plasmodium falciparum malarial parasite
A Addlagatta, R Gumpena, A Marapaka, AD Allanki, JH Jun, PS Sijwali, ...
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 247, 2014
12014
CRYSTAL STRUCTURE OF THE UDP-GLUCOSE PYROPHOSPHORYLASE FROM YERSINIA PESTIS, AN ANTI-PLAGUE DRUG TARGET
G Lountos, M Gibbs, R Gumpena, D Waugh
PROTEIN SCIENCE 28, 105-105, 2019
2019
Crystal Structure Of The UDP-Glucose Pyrophosphorylase From Yersinia Pestis, a Drug Target for New Anti-Plague Agents
GT Lountos, ME Gibbs, R Gumpena, DS Waugh
Foundations of Crystallography 75, a305, 2019
2019
Full wwPDB X-ray Structure Validation Report i○
R Reddi, R Gumpena, C Kishor, A Addlagatta
CONCISE ARTICLE
C Kishor, VR Bommena, A Addlagatta
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Articles 1–19