1,4,5,6-Tetrahydropyrrolo[3,4-c]pyrazoles: Identification of a Potent Aurora Kinase Inhibitor with a Favorable Antitumor Kinase Inhibition Profile D Fancelli, J Moll, M Varasi, R Bravo, R Artico, D Berta, S Bindi, ... Journal of medicinal chemistry 49 (24), 7247-7251, 2006 | 238 | 2006 |
Effectiveness of anthracycline against experimental prion disease in Syrian hamsters F Tagliavini, RA McArthur, B Canciani, G Giaccone, M Porro, M Bugiani, ... Science 276 (5315), 1119-1121, 1997 | 234 | 1997 |
High-throughput NMR-based screening with competition binding experiments C Dalvit, M Flocco, S Knapp, M Mostardini, R Perego, BJ Stockman, ... Journal of the american chemical society 124 (26), 7702-7709, 2002 | 205 | 2002 |
PHA-680632, a novel Aurora kinase inhibitor with potent antitumoral activity C Soncini, P Carpinelli, L Gianellini, D Fancelli, P Vianello, L Rusconi, ... Clinical Cancer Research 12 (13), 4080-4089, 2006 | 201 | 2006 |
A revised mechanism for the Mitsunobu reaction M Varasi, KAM Walker, ML Maddox The Journal of Organic Chemistry 52 (19), 4235-4238, 1987 | 190 | 1987 |
3-Aminopyrazole inhibitors of CDK2/cyclin A as antitumor agents. 1. Lead finding P Pevarello, MG Brasca, R Amici, P Orsini, G Traquandi, L Corti, C Piutti, ... Journal of medicinal chemistry 47 (13), 3367-3380, 2004 | 179 | 2004 |
Potent and selective Aurora inhibitors identified by the expansion of a novel scaffold for protein kinase inhibition D Fancelli, D Berta, S Bindi, A Cameron, P Cappella, P Carpinelli, ... Journal of medicinal chemistry 48 (8), 3080-3084, 2005 | 175 | 2005 |
3-Aminopyrazole inhibitors of CDK2/cyclin A as antitumor agents. 2. Lead optimization P Pevarello, MG Brasca, P Orsini, G Traquandi, A Longo, M Nesi, F Orzi, ... Journal of medicinal chemistry 48 (8), 2944-2956, 2005 | 140 | 2005 |
Cdc7 kinase inhibitors: pyrrolopyridinones as potential antitumor agents. 1. Synthesis and structure–activity relationships E Vanotti, R Amici, A Bargiotti, J Berthelsen, R Bosotti, A Ciavolella, ... Journal of medicinal chemistry 51 (3), 487-501, 2008 | 127 | 2008 |
Synthesis and anticonvulsant activity of a new class of 2-[(arylalkyl) amino] alkanamide derivatives P Pevarello, A Bonsignori, P Dostert, F Heidempergher, V Pinciroli, ... Journal of medicinal chemistry 41 (4), 579-590, 1998 | 126 | 1998 |
(R, S)-3, 4-dichlorobenzoylalanine (FCE 28833A) causes a large and persistent increase in brain kynurenic acid levels in rats C Speciale, HQ Wu, M Cini, M Marconi, M Varasi, R Schwarcz European journal of pharmacology 315 (3), 263-267, 1996 | 122 | 1996 |
3 (5)-amino-pyrazole derivatives, process for their preparation and their use as antitumor agents P Pevarello, P Orsini, G Traquandi, M Varasi, EL Fritzen, MA Warpehoski, ... US Patent 6,218,418, 2001 | 120 | 2001 |
Azaindole derivatives, process for their preparation, and their use as antitumor agents A Longo, MG Brasca, P Orsini, G Traquandi, V Pittalą, A Vulpetti, M Varasi, ... US Patent 6,335,342, 2002 | 114 | 2002 |
Toward highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitors G La Regina, R Bai, WM Rensen, E Di Cesare, A Coluccia, F Piscitelli, ... Journal of medicinal chemistry 56 (1), 123-149, 2013 | 106 | 2013 |
Azaindole derivatives, process for their preparation, and their use as antitumor agents A Longo, MG Brasca, P Orsini, G Traquandi, V Pittalą, A Vulpetti, M Varasi, ... US Patent 6,486,322, 2002 | 100 | 2002 |
Biochemical and electrophysiological studies on the mechanism of action of PNU-151774E, a novel antiepileptic compound P Salvati, R Maj, C Caccia, MA Cervini, MG Fornaretto, E Lamberti, ... Journal of pharmacology and experimental therapeutics 288 (3), 1151-1159, 1999 | 100 | 1999 |
Discovery, synthesis, and pharmacological evaluation of spiropiperidine hydroxamic acid based derivatives as structurally novel histone deacetylase (HDAC) inhibitors M Varasi, F Thaler, A Abate, C Bigogno, R Boggio, G Carenzi, ... Journal of Medicinal Chemistry 54 (8), 3051-3064, 2011 | 99 | 2011 |
Design and Synthesis of 2-Heterocyclyl-3-arylthio-1H-indoles as Potent Tubulin Polymerization and Cell Growth Inhibitors with Improved Metabolic Stability G La Regina, R Bai, W Rensen, A Coluccia, F Piscitelli, V Gatti, ... Journal of medicinal chemistry 54 (24), 8394-8406, 2011 | 95 | 2011 |
Kynurenergic manipulations influence excitatory synaptic function and excitotoxic vulnerability in the rat hippocampus in vivo HQ Wu, P Guidetti, JH Goodman, M Varasi, G Ceresoli-Borroni, ... Neuroscience 97 (2), 243-251, 2000 | 95 | 2000 |
Preclinical evaluation of PNU-151774E as a novel anticonvulsant RG Fariello, RA McArthur, A Bonsignori, MA Cervini, R Maj, P Marrari, ... Journal of Pharmacology and Experimental Therapeutics 285 (2), 397-403, 1998 | 85 | 1998 |