Michael J Keiser
TitleCited byYear
Predicting new molecular targets for known drugs
MJ Keiser, V Setola, JJ Irwin, C Laggner, AI Abbas, SJ Hufeisen, ...
Nature 462 (7270), 175-181, 2009
12762009
Relating protein pharmacology by ligand chemistry
MJ Keiser, BL Roth, BN Armbruster, P Ernsberger, JJ Irwin, BK Shoichet
Nature biotechnology 25 (2), 197-206, 2007
11342007
Large-scale prediction and testing of drug activity on side-effect targets
E Lounkine, MJ Keiser, S Whitebread, D Mikhailov, J Hamon, JL Jenkins, ...
Nature 486 (7403), 361-367, 2012
5922012
Quantifying biogenic bias in screening libraries
J Hert, JJ Irwin, C Laggner, MJ Keiser, BK Shoichet
Nature chemical biology 5 (7), 479-483, 2009
1942009
Complementarity between a docking and a high-throughput screen in discovering new cruzain inhibitors
RS Ferreira, A Simeonov, A Jadhav, O Eidam, BT Mott, MJ Keiser, ...
Journal of medicinal chemistry 53 (13), 4891-4905, 2010
1752010
Quantifying the relationships among drug classes
J Hert, MJ Keiser, JJ Irwin, TI Oprea, BK Shoichet
Journal of chemical information and modeling 48 (4), 755-765, 2008
1632008
Chemical informatics and target identification in a zebrafish phenotypic screen
C Laggner, D Kokel, V Setola, A Tolia, H Lin, JJ Irwin, MJ Keiser, ...
Nature chemical biology 8 (2), 144-146, 2012
1132012
The chemical basis of pharmacology
MJ Keiser, JJ Irwin, BK Shoichet
Biochemistry 49 (48), 10267-10276, 2010
1042010
Polygenic overlap between schizophrenia risk and antipsychotic response: a genomic medicine approach
DM Ruderfer, AW Charney, B Readhead, BA Kidd, AK Kähler, PJ Kenny, ...
The Lancet Psychiatry 3 (4), 350-357, 2016
622016
The presynaptic component of the serotonergic system is required for clozapine's efficacy
PN Yadav, AI Abbas, MS Farrell, V Setola, N Sciaky, XP Huang, ...
Neuropsychopharmacology 36 (3), 638-651, 2010
552010
Prediction and evaluation of protein farnesyltransferase inhibition by commercial drugs
AJ DeGraw, MJ Keiser, JD Ochocki, BK Shoichet, MD Distefano
Journal of medicinal chemistry 53 (6), 2464-2471, 2010
502010
Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds
G Bruni, AJ Rennekamp, A Velenich, M McCarroll, L Gendelev, E Fertsch, ...
Nature chemical biology 12 (7), 559-566, 2016
462016
A mapping of drug space from the viewpoint of small molecule metabolism
JC Adams, MJ Keiser, L Basuino, HF Chambers, DS Lee, OG Wiest, ...
PLoS Comput Biol 5 (8), e1000474, 2009
392009
Systems Pharmacology Augments Drug Safety Surveillance
T Lorberbaum, M Nasir, MJ Keiser, S Vilar, G Hripcsak, NP Tatonetti
Clinical Pharmacology & Therapeutics 97 (2), 151-158, 2015
272015
Prediction and validation of enzyme and transporter off-targets for metformin
SW Yee, L Lin, M Merski, MJ Keiser, A Gupta, Y Zhang, HC Chien, ...
Journal of pharmacokinetics and pharmacodynamics 42 (5), 463-475, 2015
262015
Off-target networks derived from ligand set similarity
MJ Keiser, J Hert
Chemogenomics, 195-205, 2009
202009
The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders
AJ Willsey, MT Morris, S Wang, HR Willsey, N Sun, N Teerikorpi, TB Baum, ...
Cell 174 (3), 505-520, 2018
172018
Leveraging large-scale behavioral profiling in zebrafish to explore neuroactive polypharmacology
MN McCarroll, L Gendelev, MJ Keiser, D Kokel
ACS chemical biology 11 (4), 842-849, 2016
172016
In silico molecular comparisons of C. elegans and mammalian pharmacology identify distinct targets that regulate feeding
GA Lemieux, MJ Keiser, MF Sassano, C Laggner, F Mayer, RJ Bainton, ...
PLoS Biol 11 (11), e1001712, 2013
162013
Comment on “Predicting reaction performance in C–N cross-coupling using machine learning”
KV Chuang, MJ Keiser
Science 362 (6416), eaat8603, 2018
152018
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Articles 1–20