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Timothy Stachowski
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Water Networks Repopulate Protein–Ligand Interfaces with Temperature
TR Stachowski, M Vanarotti, J Seetharaman, K Lopez, M Fischer
Angewandte Chemie 134 (31), e202112919, 2022
162022
Structural consequences of transforming growth factor beta-1 activation from near-therapeutic X-ray doses
T Stachowski, TD Grant, EH Snell
Journal of Synchrotron Radiation 26 (4), 967-979, 2019
112019
Large-scale ligand perturbations of the protein conformational landscape reveal state-specific interaction hotspots
TR Stachowski, M Fischer
Journal of Medicinal Chemistry 65 (20), 13692-13704, 2022
92022
SAXS studies of X-ray induced disulfide bond damage: Engineering high-resolution insight from a low-resolution technique
TR Stachowski, ME Snell, EH Snell
PLoS ONE 15 (11), e0239702, 2020
92020
FLEXR: automated multi-conformer model building using electron-density map sampling
TR Stachowski, M Fischer
Acta Crystallographica Section D: Structural Biology 79 (5), 2023
82023
Structural insights into conformational switching in latency-associated peptide between transforming growth factor β-1 bound and unbound states
TR Stachowski, ME Snell, EH Snell
IUCrJ 7 (2), 238-252, 2020
62020
A SAXS-based approach to rationally evaluate radical scavengers–toward eliminating radiation damage in solution and crystallographic studies
TR Stachowski, ME Snell, EH Snell
Journal of Synchrotron Radiation 28 (5), 1309-1320, 2021
42021
From PROTAC to inhibitor: Structure-guided discovery of potent and orally bioavailable BET inhibitors
M Koravovic, A Mayasundari, G Tasic, F Keramatnia, TR Stachowski, ...
European Journal of Medicinal Chemistry 251, 115246, 2023
12023
FLEXR GUI: a graphical user interface for multi-conformer modeling of proteins
TR Stachowski, M Fischer
Journal of Applied Crystallography 57 (2), 2024
2024
Hiding in plain sight: distilling protein–ligand hotspots from hundreds of Hsp90 crystal structures
TR Stachowski, M Fischer
Acta Crystallographica Section A: Foundations and Advances 79, a85-a85, 2023
2023
Pan‐HSP90 ligand binding reveals isoform‐specific differences in plasticity and water networks
TR Stachowski, S Nithianantham, M Vanarotti, K Lopez, M Fischer
Protein Science 32 (5), e4629, 2023
2023
The big thaw: waters freed from cryo-cooling yield dynamic protein-ligand interactions
T Stachowski, M Vanarotti, S Nithianantham, S Jayaraman, K Lopez, ...
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES 78, A18-A18, 2022
2022
An objective metric to guide background correction and interpretation of small angle X-ray scattering data
Y Gao, TR Stachowski, EH Snell, TD Grant, AR Pearson
Acta Crystallographica Section A: Foundations and Advances 77, C204-C204, 2021
2021
Nove protein-ligand interakcije amidnih BET inhibitora otkrivene derivatizacijom (+)-JQ1 molekula
M Koravović, G Tasić, A Mayasundari, F Keramatnia, T Stachowski, ...
Konkurs za izbor najboljih naučno-istraživačkih radova studenata doktorskih …, 2021
2021
SAXS studies of X-ray induced disulfide bond damage: Engineering high-resolution insight into a low resolution technique
T Stachowski, E Snell, E Snell
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES 76, A4-A4, 2020
2020
Towards Understanding the Structural Impact from Therapeutic Radiation Doses: from Mechanisms in Engineered Systems to TGF-β1
TR Stachowski
State University of New York at Buffalo, 2020
2020
Structural studies on low-dose X-ray radiation induced Transforming growth factor beta-1 (TGF beta-1) activation
TR Stachowski, TD Grant, EH Snell
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES 75, A82-A82, 2019
2019
Determining the CQC-Mediated Interactions in the Mucin 1 Homodimer
E Bilyk, C Freeman, T Stachowski, E Li
Biophysical Journal 110 (3), 581a, 2016
2016
Elucidating the structural consequences of CQC‐mediated dimerization of MUC1
T Stachowski, E Li
The FASEB Journal 29, 574.21, 2015
2015
Determining the key residues within the MUC1 transmembrane domain dimer.
E Li, T Stachowski, C Freeman
MOLECULAR BIOLOGY OF THE CELL 25, 2014
2014
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Articles 1–20