| A randomised trial of the effect of omega-3 polyunsaturated fatty acid supplements on the human intestinal microbiota H Watson, S Mitra, FC Croden, M Taylor, HM Wood, SL Perry, JA Spencer, ... Gut 67 (11), 1974-1983, 2018 | 428 | 2018 |
| Design, Synthesis, and Biophysical and Biological Evaluation of a Series of Pyrrolobenzodiazepine−Poly(N-methylpyrrole) Conjugates G Wells, CRH Martin, PW Howard, ZA Sands, CA Laughton, A Tiberghien, ... Journal of medicinal chemistry 49 (18), 5442-5461, 2006 | 170 | 2006 |
| Development of novel tumor‐targeted theranostic nanoparticles activated by membrane‐type matrix metalloproteinases for combined cancer magnetic resonance imaging and therapy C Ansari, GA Tikhomirov, SH Hong, RA Falconer, PM Loadman, JH Gill, ... Small 10 (3), 566-575, 2014 | 161 | 2014 |
| Hypoxia-selective targeting by the bioreductive prodrug AQ4N in patients with solid tumors: results of a phase I study MR Albertella, PM Loadman, PH Jones, RM Phillips, R Rampling, ... Clinical cancer research 14 (4), 1096-1104, 2008 | 150 | 2008 |
| Reduction of tumor blood flow by flavone acetic acid: a possible component of therapy MC Bibby, JA Double, PM Loadman, CV Duke JNCI: Journal of the National Cancer Institute 81 (3), 216-220, 1989 | 148 | 1989 |
| Phase I study of sequence-selective minor groove DNA binding agent SJG-136 in patients with advanced solid tumors D Hochhauser, T Meyer, VJ Spanswick, J Wu, PH Clingen, P Loadman, ... Clinical Cancer Research 15 (6), 2140-2147, 2009 | 147 | 2009 |
| Cytochrome P450 1B1 (CYP1B1) is overexpressed in human colon adenocarcinomas relative to normal colon: implications for drug development P Gibson, JH Gill, PA Khan, JM Seargent, SW Martin, PA Batman, J Griffith, ... Molecular cancer therapeutics 2 (6), 527-534, 2003 | 144 | 2003 |
| Detergent addition to tryptic digests and ion mobility separation prior to MS/MS improves peptide yield and protein identification for in situ proteomic investigation of … MC Djidja, S Francese, PM Loadman, CW Sutton, P Scriven, E Claude, ... Proteomics 9 (10), 2750-2763, 2009 | 140 | 2009 |
| Comparative preclinical pharmacokinetic and metabolic studies of the combretastatin prodrugs combretastatin A4 phosphate and A1 phosphate IG Kirwan, PM Loadman, DJ Swaine, DA Anthoney, GR Pettit, ... Clinical Cancer Research 10 (4), 1446-1453, 2004 | 133 | 2004 |
| Eicosapentaenoic acid and aspirin, alone and in combination, for the prevention of colorectal adenomas (seAFOod Polyp Prevention trial): a multicentre, randomised, double-blind … MA Hull, K Sprange, T Hepburn, W Tan, A Shafayat, CJ Rees, G Clifford, ... The Lancet 392 (10164), 2583-2594, 2018 | 130 | 2018 |
| 5, 6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent: phase I clinical and pharmacokinetic study GJS Rustin, C Bradley, S Galbraith, M Stratford, P Loadman, S Waller, ... British journal of cancer 88 (8), 1160-1167, 2003 | 124 | 2003 |
| Combination chemotherapy with combretastatin A-4 phosphate and 5-fluorouracil in an experimental murine colon adenocarcinoma. K Grosios, PM Loadman, DJ Swaine, GR Pettit, MC Bibby Anticancer research 20 (1A), 229-233, 2000 | 121 | 2000 |
| Examination of the distribution of the bioreductive drug AQ4N and its active metabolite AQ4 in solid tumours by imaging matrix‐assisted laser desorption/ionisation mass … SJ Atkinson, PM Loadman, C Sutton, LH Patterson, MR Clench Rapid Communications in Mass Spectrometry: An International Journal Devoted …, 2007 | 117 | 2007 |
| Anticolorectal cancer activity of the omega-3 polyunsaturated fatty acid eicosapentaenoic acid AJ Cockbain, M Volpato, AD Race, A Munarini, C Fazio, A Belluzzi, ... Gut 63 (11), 1760-1768, 2014 | 114 | 2014 |
| Proteases in cancer drug delivery J Vandooren, G Opdenakker, PM Loadman, DR Edwards Advanced Drug Delivery Reviews 97, 144-155, 2016 | 105 | 2016 |
| FGFR1-induced epithelial to mesenchymal transition through MAPK/PLCγ/COX-2-mediated mechanisms DC Tomlinson, EW Baxter, PM Loadman, MA Hull, MA Knowles PloS one 7 (6), e38972, 2012 | 105 | 2012 |
| Evaluation of a novel in vitro assay for assessing drug penetration into avascular regions of tumours RM Phillips, PM Loadman, BP Cronin British journal of cancer 77 (12), 2112-2119, 1998 | 105 | 1998 |
| MMP-10 is overexpressed, proteolytically active, and a potential target for therapeutic intervention in human lung carcinomas JH Gill, IG Kirwan, JM Seargent, SW Martin, S Tijani, VA Anikin, ... Neoplasia 6 (6), 777-785, 2004 | 98 | 2004 |
| Effect of eicosapentaenoic acid on E-type prostaglandin synthesis and EP4 receptor signaling human colorectal cancer cells G Hawcroft, PM Loadman, A Belluzzi, MA Hull Neoplasia 12 (8), 618-IN2, 2010 | 95 | 2010 |
| Eicosapentaenoic acid free fatty acid prevents and suppresses colonic neoplasia in colitis‐associated colorectal cancer acting on Notch signaling and gut microbiota G Piazzi, G D'Argenio, A Prossomariti, V Lembo, G Mazzone, M Candela, ... International journal of cancer 135 (9), 2004-2013, 2014 | 90 | 2014 |
