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Crystal structures of a ZIP zinc transporter reveal a binuclear metal center in the transport pathway
T Zhang, J Liu, M Fellner, C Zhang, D Sui, J Hu
Science advances 3 (8), e1700344, 2017
1502017
Structural basis for regulation of human calcium-sensing receptor by magnesium ions and an unexpected tryptophan derivative co-agonist
C Zhang, T Zhang, J Zou, CL Miller, R Gorkhali, JY Yang, A Schilmiller, ...
Science advances 2 (5), e1600241, 2016
1322016
A tethered niacin-derived pincer complex with a nickel-carbon bond in lactate racemase
B Desguin, T Zhang, P Soumillion, P Hols, J Hu, RP Hausinger
Science 349 (6243), 66-69, 2015
982015
Structural insights of ZIP4 extracellular domain critical for optimal zinc transport
T Zhang, D Sui, J Hu
Nature communications 7 (1), 11979, 2016
832016
The crystal structure of GXGD membrane protease FlaK
J Hu, Y Xue, S Lee, Y Ha
Nature 475 (7357), 528-531, 2011
812011
Structural biology of transmembrane domains: efficient production and characterization of transmembrane peptides by NMR
J Hu, H Qin, C Li, M Sharma, TA Cross, FP Gao
Protein Science 16 (10), 2153-2165, 2007
682007
Lipid bilayers: an essential environment for the understanding of membrane proteins
RC Page, C Li, J Hu, FP Gao, TA Cross
Magnetic Resonance in Chemistry 45 (S1), S2-S11, 2007
662007
Construction of a series of vectors for high throughput cloning and expression screening of membrane proteins from Mycobacterium tuberculosis
H Qin, J Hu, Y Hua, SV Challa, TA Cross, FP Gao
BMC biotechnology 8, 1-8, 2008
642008
Structures and mechanisms of the non-heme Fe (II)-and 2-oxoglutarate-dependent ethylene-forming enzyme: substrate binding creates a twist
S Martinez, M Fellner, CQ Herr, A Ritchie, J Hu, RP Hausinger
Journal of the American Chemical Society 139 (34), 11980-11988, 2017
602017
Resolution of structure of PIP5K1A reveals molecular mechanism for its regulation by dimerization and dishevelled
J Hu, Q Yuan, X Kang, Y Qin, L Li, Y Ha, D Wu
Nature communications 6 (1), 8205, 2015
522015
The E2 domains of APP and APLP1 share a conserved mode of dimerization
S Lee, Y Xue, J Hu, Y Wang, X Liu, B Demeler, Y Ha
Biochemistry 50 (24), 5453-5464, 2011
512011
Toward unzipping the ZIP metal transporters: structure, evolution, and implications on drug discovery against cancer
J Hu
The FEBS journal 288 (20), 5805-5825, 2021
472021
A systematic assessment of mature MBP in membrane protein production: overexpression, membrane targeting and purification
J Hu, H Qin, FP Gao, TA Cross
Protein expression and purification 80 (1), 34-40, 2011
462011
Biosynthesis of the nickel-pincer nucleotide cofactor of lactate racemase requires a CTP-dependent cyclometallase
B Desguin, M Fellner, O Riant, J Hu, RP Hausinger, P Hols, P Soumillion
Journal of Biological Chemistry 293 (32), 12303-12317, 2018
402018
Lanthanide-dependent alcohol dehydrogenases require an essential aspartate residue for metal coordination and enzymatic function
NM Good, M Fellner, K Demirer, J Hu, RP Hausinger, ...
Journal of Biological Chemistry 295 (24), 8272-8284, 2020
392020
Binding of La3+ to calmodulin and its effects on the interaction between calmodulin and calmodulin binding peptide, polistes mastoparan
J Hu, X Jia, Q Li, X Yang, K Wang
Biochemistry 43 (10), 2688-2698, 2004
382004
Asymmetric functions of a binuclear metal center within the transport pathway of a human zinc transporter ZIP4
T Zhang, D Sui, C Zhang, L Cole, J Hu
FASEB journal: official publication of the Federation of American Societies …, 2020
372020
Structural insights into the catalytic mechanism of a sacrificial sulfur insertase of the N-type ATP pyrophosphatase family, LarE
M Fellner, B Desguin, RP Hausinger, J Hu
Proceedings of the National Academy of Sciences 114 (34), 9074-9079, 2017
372017
The activation loop of PIP5K functions as a membrane sensor essential for lipid substrate processing
A Liu, D Sui, D Wu, J Hu
Science advances 2 (11), e1600925, 2016
372016
Advances in the development of class i phosphoinositide 3-kinase (PI3K) inhibitors
DA Sabbah, J Hu, HA Zhong
Curr. Top. Med. Chem 16 (13), 1413-1426, 2016
352016
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Articles 1–20