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Amit Choudhary
Amit Choudhary
Assistant Professor of Medicine, Harvard Medical School
Verified email at broadinstitute.org - Homepage
Title
Cited by
Cited by
Year
n→ π* interactions in proteins
GJ Bartlett, A Choudhary, RT Raines, DN Woolfson
Nature chemical biology 6 (8), 615-620, 2010
3202010
Targeting the pancreatic β-cell to treat diabetes
A Vetere, A Choudhary, S Burns, B Wagner
Nature Reviews Drug Discovery, 2014
2852014
Nature of amide carbonyl− carbonyl interactions in proteins
A Choudhary, D Gandla, GR Krow, RT Raines
Journal of the American Chemical Society 131 (21), 7244-7246, 2009
2492009
An evaluation of peptide‐bond isosteres
A Choudhary, RT Raines
ChemBioChem 12 (12), 1801-1807, 2011
2062011
Multidimensional chemical control of CRISPR–Cas9
B Maji, CL Moore, B Zetsche, SE Volz, F Zhang, MD Shoulders, ...
Nature chemical biology 13 (1), 9-11, 2017
1322017
n → π* Interaction and n)(π Pauli Repulsion Are Antagonistic for Protein Stability
CE Jakobsche, A Choudhary, SJ Miller, RT Raines
Journal of the American Chemical Society 132 (19), 6651-6653, 2010
1242010
A high-throughput platform to identify small-molecule inhibitors of CRISPR-Cas9
B Maji, SA Gangopadhyay, M Lee, M Shi, P Wu, R Heler, B Mok, D Lim, ...
Cell 177 (4), 1067-1079. e19, 2019
1142019
Intimate Interactions with Carbonyl Groups: Dipole–Dipole or n→π*?
KJ Kamer, A Choudhary, RT Raines
The Journal of organic chemistry 78 (5), 2099-2103, 2013
892013
Precision control of CRISPR-Cas9 using small molecules and light
SA Gangopadhyay, KJ Cox, D Manna, D Lim, B Maji, Q Zhou, ...
Biochemistry 58 (4), 234-244, 2019
702019
The Aberrance of the 4S Diastereomer of 4-Hydroxyproline
MD Shoulders, FW Kotch, A Choudhary, IA Guzei, RT Raines
Journal of the American Chemical Society 132 (31), 10857-10865, 2010
692010
An n→π* Interaction in Aspirin: Implications for Structure and Reactivity
A Choudhary, KJ Kamer, RT Raines
The Journal of organic chemistry 76 (19), 7933-7937, 2011
632011
Signature of n→ π* interactions in α‐helices
A Choudhary, RT Raines
Protein Science 20 (6), 1077-1081, 2011
592011
A stereoelectronic effect in prebiotic nucleotide synthesis
A Choudhary, KJ Kamer, MW Powner, JD Sutherland, RT Raines
ACS chemical biology 5 (7), 655-657, 2010
542010
n→π* Interactions Engender Chirality in Carbonyl Groups
A Choudhary, RW Newberry, RT Raines
Organic letters 16 (13), 3421-3423, 2014
432014
Core commitments for field trials of gene drive organisms
KC Long, L Alphey, GJ Annas, CS Bloss, KJ Campbell, J Champer, ...
Science 370 (6523), 1417-1419, 2020
402020
Phosphorylation-inducing chimeric small molecules
SU Siriwardena, DNP Munkanatta Godage, VM Shoba, S Lai, M Shi, ...
Journal of the American Chemical Society 142 (33), 14052-14057, 2020
362020
Small-molecule control of super-Mendelian inheritance in gene drives
VL Del Amo, BS Leger, KJ Cox, S Gill, AL Bishop, GD Scanlon, JA Walker, ...
Cell reports 31 (13), 107841, 2020
332020
Growth and stress response mechanisms underlying post-feeding regenerative organ growth in the Burmese python
AL Andrew, BW Perry, DC Card, DR Schield, RP Ruggiero, SE McGaugh, ...
BMC genomics 18 (1), 1-18, 2017
322017
An n→ π* interaction reduces the electrophilicity of the acceptor carbonyl group
A Choudhary, CG Fry, KJ Kamer, RT Raines
Chemical Communications 49 (74), 8166-8168, 2013
312013
Quantum mechanical origin of the conformational preferences of 4-thiaproline and its S-oxides
A Choudhary, KH Pua, RT Raines
Amino Acids 41 (1), 181-186, 2011
282011
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