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Lora K Picton
Lora K Picton
Research Scientist, Stanford University
Verified email at stanford.edu
Title
Cited by
Cited by
Year
The putative Drp1 inhibitor mdivi-1 is a reversible mitochondrial complex I inhibitor that modulates reactive oxygen species
EA Bordt, P Clerc, BA Roelofs, AJ Saladino, L Tretter, V Adam-Vizi, ...
Developmental cell 40 (6), 583-594. e6, 2017
4542017
Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes
JT Sockolosky, E Trotta, G Parisi, L Picton, LL Su, AC Le, A Chhabra, ...
Science 359 (6379), 1037-1042, 2018
2912018
Design of protein-binding proteins from the target structure alone
L Cao, B Coventry, I Goreshnik, B Huang, W Sheffler, JS Park, KM Jude, ...
Nature 605 (7910), 551-560, 2022
2212022
Alternative evolutionary histories in the sequence space of an ancient protein
TN Starr, LK Picton, JW Thornton
Nature 549 (7672), 409-413, 2017
1882017
An engineered IL-2 partial agonist promotes CD8+ T cell stemness
F Mo, Z Yu, P Li, J Oh, R Spolski, L Zhao, CR Glassman, TN Yamamoto, ...
Nature 597 (7877), 544-548, 2021
1062021
Direct binding of the dynamin-like GTPase, Dnm1, to mitochondrial dynamics protein Fis1 is negatively regulated by the Fis1 N-terminal arm
RC Wells, LK Picton, SCP Williams, FJ Tan, RB Hill
Journal of Biological Chemistry 282 (46), 33769-33775, 2007
822007
A human orthogonal IL-2 and IL-2Rβ system enhances CAR T cell expansion and antitumor activity in a murine model of leukemia
Q Zhang, ME Hresko, LK Picton, L Su, MJ Hollander, S Nunez-Cruz, ...
Science translational medicine 13 (625), eabg6986, 2021
732021
Immune receptor inhibition through enforced phosphatase recruitment
RA Fernandes, L Su, Y Nishiga, J Ren, AM Bhuiyan, N Cheng, CJ Kuo, ...
Nature 586 (7831), 779-784, 2020
662020
Selective expansion of regulatory T cells using an orthogonal IL-2/IL-2 receptor system facilitates transplantation tolerance
T Hirai, TL Ramos, PY Lin, F Simonetta, LL Su, LK Picton, J Baker, JX Lin, ...
The Journal of clinical investigation 131 (8), 2021
552021
Potentiating adoptive cell therapy using synthetic IL-9 receptors
A Kalbasi, M Siurala, LL Su, M Tariveranmoshabad, LK Picton, ...
Nature 607 (7918), 360-365, 2022
452022
Role of conserved cysteines in the alphavirus E3 protein
MM Parrott, SA Sitarski, RJ Arnold, LK Picton, RB Hill, S Mukhopadhyay
Journal of virology 83 (6), 2584-2591, 2009
392009
Facile discovery of surrogate cytokine agonists
M Yen, J Ren, Q Liu, CR Glassman, TP Sheahan, LK Picton, FR Moreira, ...
Cell 185 (8), 1414-1430. e19, 2022
342022
Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist
CR Glassman, L Su, SS Majri-Morrison, H Winkelmann, F Mo, P Li, ...
Elife 10, e65777, 2021
252021
Synergy of a STING agonist and an IL-2 superkine in cancer immunotherapy against MHC I–deficient and MHC I+ tumors
NK Wolf, C Blaj, LK Picton, G Snyder, L Zhang, CJ Nicolai, CO Ndubaku, ...
Proceedings of the National Academy of Sciences 119 (22), e2200568119, 2022
212022
A designed point mutant in Fis1 disrupts dimerization and mitochondrial fission
JPB Lees, CM Manlandro, LK Picton, AZE Tan, S Casares, JM Flanagan, ...
Journal of molecular biology 423 (2), 143-158, 2012
172012
Biologically relevant orthogonal cytokine/receptor pairs
KC Garcia, J Sockolosky, L Picton
US Patent 10,869,887, 2020
152020
Prevention of acute GVHD using an orthogonal IL-2/IL-2Rβ system to selectively expand regulatory T cells in vivo
TL Ramos, S Bolivar-Wagers, S Jin, G Thangavelu, F Simonetta, PY Lin, ...
Blood, The Journal of the American Society of Hematology 141 (11), 1337-1352, 2023
142023
Robust de novo design of protein binding proteins from target structural information alone
L Cao, B Coventry, I Goreshnik, B Huang, JS Park, KM Jude, I Marković, ...
BioRxiv, 2021.09. 04.459002, 2021
142021
Interleukin-2 superkines by computational design
J Ren, AE Chu, KM Jude, LK Picton, AJ Kare, L Su, A Montano Romero, ...
Proceedings of the National Academy of Sciences 119 (12), e2117401119, 2022
132022
Enhanced STAT5a activation rewires exhausted CD8 T cells during chronic stimulation to acquire a hybrid durable effector like state
JC Beltra, MS Abdel-Hakeem, S Manne, Z Zhang, H Huang, M Kurachi, ...
BioRxiv, 2022.10. 03.509766, 2022
122022
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