Pieter R Cullis
Pieter R Cullis
Professor Biochemistry, University of BC
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Cited by
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Drug delivery systems: entering the mainstream
TM Allen, PR Cullis
Science 303 (5665), 1818-1822, 2004
Liposomal drug delivery systems: from concept to clinical applications
TM Allen, PR Cullis
Advanced drug delivery reviews 65 (1), 36-48, 2013
Production of large unilamellar vesicles by a rapid extrusion procedure. Characterization of size distribution, trapped volume and ability to maintain a membrane potential
MJ Hope, MB Bally, G Webb, PR Cullis
Biochimica et Biophysica Acta (BBA)-Biomembranes 812 (1), 55-65, 1985
Vesicles of variable sizes produced by a rapid extrusion procedure
LD Mayer, MJ Hope, PR Cullis
Biochimica et Biophysica Acta (BBA)-Biomembranes 858 (1), 161-168, 1986
Rational design of cationic lipids for siRNA delivery
SC Semple, A Akinc, J Chen, AP Sandhu, BL Mui, CK Cho, DWY Sah, ...
Nature biotechnology 28 (2), 172-176, 2010
Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo
M Jayaraman, SM Ansell, BL Mui, YK Tam, J Chen, X Du, D Butler, ...
Angewandte Chemie 124 (34), 8657-8661, 2012
The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs
A Akinc, MA Maier, M Manoharan, K Fitzgerald, M Jayaraman, S Barros, ...
Nature nanotechnology 14 (12), 1084-1087, 2019
Lipid nanoparticle systems for enabling gene therapies
PR Cullis, MJ Hope
Molecular Therapy 25 (7), 1467-1475, 2017
Liposomal compositions for enhanced retention of bioactive agents
MB Bally, NL Boman, PR Cullis, LD Mayer
US Patent 5,595,756, 1997
The current landscape of nucleic acid therapeutics
JA Kulkarni, D Witzigmann, SB Thomson, S Chen, BR Leavitt, PR Cullis, ...
Nature nanotechnology 16 (6), 630-643, 2021
Microfluidic synthesis of highly potent limit-size lipid nanoparticles for in vivo delivery of siRNA
NM Belliveau, J Huft, PJC Lin, S Chen, AKK Leung, TJ Leaver, AW Wild, ...
Molecular Therapy-Nucleic Acids 1, 2012
On the mechanism whereby cationic lipids promote intracellular delivery of polynucleic acids
IM Hafez, N Maurer, PR Cullis
Gene therapy 8 (15), 1188-1196, 2001
Nomenclature for synthetic gene delivery systems
PL Felgner, Y Barenholz, JP Behr, SH Cheng, P Cullis, L Huang, ...
Human gene therapy 8 (5), 511-512, 1997
Association of blood proteins with large unilamellar liposomes in vivo. Relation to circulation lifetimes.
A Chonn, SC Semple, PR Cullis
Journal of Biological Chemistry 267 (26), 18759-18765, 1992
Solute distributions and trapping efficiencies observed in freeze-thawed multilamellar vesicles
LD Mayer, MJ Hope, PR Cullis, AS Janoff
Biochimica et Biophysica Acta (BBA)-Biomembranes 817 (1), 193-196, 1985
Efficient encapsulation of antisense oligonucleotides in lipid vesicles using ionizable aminolipids: formation of novel small multilamellar vesicle structures
SC Semple, SK Klimuk, TO Harasym, N Dos Santos, SM Ansell, KF Wong, ...
Biochimica et Biophysica Acta (BBA)-Biomembranes 1510 (1-2), 152-166, 2001
Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
JJ Wheeler, MB Bally, YP Zhang, DL Reimer, M Hope, PR Cullis, ...
US Patent 5,976,567, 1999
Generation of multilamellar and unilamellar phospholipid vesicles
MJ Hope, MB Bally, LD Mayer, AS Janoff, PR Cullis
Chemistry and physics of lipids 40 (2-4), 89-107, 1986
The liposomal formulation of doxorubicin
SA Abraham, DN Waterhouse, LD Mayer, PR Cullis, TD Madden, ...
Methods in enzymology 391, 71-97, 2005
The polymorphic phase behaviour of phosphatidylethanolamines of natural and synthetic origin. A 31P NMR study
PR Cullis, B De Kruijff
Biochimica et Biophysica Acta (BBA)-Biomembranes 513 (1), 31-42, 1978
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