| Mammalian thioredoxin is a direct inhibitor of apoptosis signal‐regulating kinase (ASK) 1 M Saitoh, H Nishitoh, M Fujii, K Takeda, K Tobiume, Y Sawada, ... The EMBO journal, 1998 | 2909 | 1998 |
| ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats H Nishitoh, A Matsuzawa, K Tobiume, K Saegusa, K Takeda, K Inoue, ... Genes & development 16 (11), 1345-1355, 2002 | 1648 | 2002 |
| ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis K Tobiume, A Matsuzawa, T Takahashi, H Nishitoh, K Morita, K Takeda, ... EMBO reports, 2001 | 1428 | 2001 |
| ASK1 is essential for JNK/SAPK activation by TRAF2 H Nishitoh, M Saitoh, Y Mochida, K Takeda, H Nakano, M Rothe, ... Molecular cell 2 (3), 389-395, 1998 | 828 | 1998 |
| ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity A Matsuzawa, K Saegusa, T Noguchi, C Sadamitsu, H Nishitoh, S Nagai, ... Nature immunology 6 (6), 587-592, 2005 | 752 | 2005 |
| Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx HY Chang, H Nishitoh, X Yang, H Ichijo, D Baltimore Science 281 (5384), 1860-1863, 1998 | 738 | 1998 |
| Activation of apoptosis signal-regulating kinase 1 (ASK1) by tumor necrosis factor receptor-associated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin H Liu, H Nishitoh, H Ichijo, JM Kyriakis Molecular and cellular biology, 2000 | 637 | 2000 |
| ALS-linked mutant SOD1 induces ER stress-and ASK1-dependent motor neuron death by targeting Derlin-1 H Nishitoh, H Kadowaki, A Nagai, T Maruyama, T Yokota, H Fukutomi, ... Genes & development 22 (11), 1451-1464, 2008 | 606 | 2008 |
| CHOP is a multifunctional transcription factor in the ER stress response H Nishitoh The Journal of Biochemistry 151 (3), 217-219, 2012 | 510 | 2012 |
| Amyloid β induces neuronal cell death through ROS-mediated ASK1 activation H Kadowaki, H Nishitoh, F Urano, C Sadamitsu, A Matsuzawa, K Takeda, ... Cell Death & Differentiation 12 (1), 19-24, 2005 | 485 | 2005 |
| Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5 H Nishitoh, H Ichijo, M Kimura, T Matsumoto, F Makishima, A Yamaguchi, ... Journal of biological chemistry 271 (35), 21345-21352, 1996 | 436 | 1996 |
| Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress K Morita, M Saitoh, K Tobiume, H Matsuura, S Enomoto, H Nishitoh, ... The EMBO journal, 2001 | 361 | 2001 |
| Physiological roles of ASK1-mediated signal transduction in oxidative stress-and endoplasmic reticulum stress-induced apoptosis: advanced findings from ASK1 knockout mice A Matsuzawa, H Nishitoh, K Tobiume, K Takeda, H Ichijo Antioxidants and Redox Signaling 4 (3), 415-425, 2002 | 306 | 2002 |
| Roles of MAPKKK ASK1 in stress-induced cell death K Takeda, A Matsuzawa, H Nishitoh, H Ichijo Cell structure and function 28 (1), 23-29, 2003 | 290 | 2003 |
| Tumor growth inhibition by arsenic trioxide (As2O3) in the orthotopic metastasis model of androgen-independent prostate cancer H Maeda, S Hori, H Nishitoh, H Ichijo, O Ogawa, Y Kakehi, A Kakizuka Cancer research 61 (14), 5432-5440, 2001 | 250 | 2001 |
| The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis K Imamura, Y Izumi, A Watanabe, K Tsukita, K Woltjen, T Yamamoto, ... Science Translational Medicine 9 (391), eaaf3962, 2017 | 234 | 2017 |
| Involvement of ASK1 in Ca2+‐induced p38 MAP kinase activation K Takeda, A Matsuzawa, H Nishitoh, K Tobiume, S Kishida, ... EMBO reports 5 (2), 161-166, 2004 | 211 | 2004 |
| Apoptosis signal-regulating kinase 1 (ASK1) induces neuronal differentiation and survival of PC12 cells K Takeda, T Hatai, TS Hamazaki, H Nishitoh, M Saitoh, H Ichijo Journal of Biological Chemistry 275 (13), 9805-9813, 2000 | 209 | 2000 |
| Survival and apoptosis signals in ER stress: the role of protein kinases H Kadowaki, H Nishitoh, H Ichijo Journal of chemical neuroanatomy 28 (1-2), 93-100, 2004 | 196 | 2004 |
| Signaling pathways from the endoplasmic reticulum and their roles in disease H Kadowaki, H Nishitoh Genes 4 (3), 306-333, 2013 | 185 | 2013 |
