| A potent and selective small-molecule degrader of STAT3 achieves complete tumor regression in vivo L Bai, H Zhou, R Xu, Y Zhao, K Chinnaswamy, D McEachern, J Chen, ... Cancer cell 36 (5), 498-511. e17, 2019 | 430 | 2019 |
| Discovery of ERD-308 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Estrogen Receptor (ER) SW Jiantao Hu, Biao Hu, Mingliang Wang, Fuming Xu, Bukeyan Miao, Chao-Yie ... Journal of Medicinal Chemistry 62 (3), 1420–1442, 2019 | 225 | 2019 |
| Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein H Zhou, L Bai, R Xu, Y Zhao, J Chen, D McEachern, K Chinnaswamy, ... Journal of medicinal chemistry 62 (24), 11280-11300, 2019 | 154 | 2019 |
| Simple structural modifications converting a bona fide MDM2 PROTAC degrader into a molecular glue molecule: a cautionary tale in the design of PROTAC degraders J Yang, Y Li, A Aguilar, Z Liu, CY Yang, S Wang Journal of Medicinal Chemistry 62 (21), 9471-9487, 2019 | 121 | 2019 |
| Medicinal Chemistry Projects Requiring Imaginative Structure-Based Drug Design Methods N Moitessier, J Pottel, E Therrien, P Englebienne, Z Liu, A Tomberg, ... Accounts of Chemical Research 49 (9), 1646-1657, 2016 | 60 | 2016 |
| A Platinum (II) Phenylphenanthroimidazole with an Extended Side‐Chain Exhibits Slow Dissociation from ac‐Kit G‐Quadruplex Motif KJ Castor, Z Liu, J Fakhoury, MA Hancock, A Mittermaier, N Moitessier, ... Chemistry–A European Journal 19 (52), 17836-17845, 2013 | 39 | 2013 |
| Structure-based design in the GPCR target space M Kontoyianni, Z Liu Current medicinal chemistry 19 (4), 544-556, 2012 | 33 | 2012 |
| A structure-based approach to understanding somatostatin receptor-4 agonism (sst4) Z Liu, AM Crider, D Ansbro, C Hayes, M Kontoyianni Journal of chemical information and modeling 52 (1), 171-186, 2012 | 32 | 2012 |
| Discovery of M-808 as a Highly Potent, Covalent, Small-Molecule Inhibitor of the Menin–MLL Interaction with Strong In Vivo Antitumor Activity S Xu, A Aguilar, L Huang, T Xu, K Zheng, D McEachern, S Przybranowski, ... Journal of Medicinal Chemistry 63 (9), 4997-5010, 2020 | 26 | 2020 |
| Understanding P450‐mediated Bio‐transformations into Epoxide and Phenolic Metabolites A Tomberg, J Pottel, Z Liu, P Labute, N Moitessier Angewandte Chemie International Edition 54 (46), 13743-13747, 2015 | 19 | 2015 |
| Atom Types Independent Molecular Mechanics Method for Predicting the Conformational Energy of Small Molecules Z Liu, SJ Barigye, M Shahamat, P Labute, N Moitessier Journal of chemical information and modeling 58 (1), 194-205, 2018 | 18 | 2018 |
| Elucidating Hyperconjugation from Electronegativity to Predict Drug Conformational Energy in a High Throughput Manner Z Liu, J Pottel, M Shahamat, A Tomberg, P Labute, N Moitessier Journal of chemical information and modeling 56 (4), 788-801, 2016 | 16 | 2016 |
| Torsional Energy Barriers of Biaryls Could Be Predicted by Electron Richness/Deficiency of Aromatic Rings; Advancement of Molecular Mechanics toward Atom-Type Independence W Wei, C Champion, Z Liu, SJ Barigye, P Labute, N Moitessier Journal of chemical information and modeling 59 (11), 4764-4777, 2019 | 14 | 2019 |
| Discovery of M-1121 as an Orally Active Covalent Inhibitor of Menin-MLL Interaction Capable of Achieving Complete and Long-Lasting Tumor Regression M Zhang, A Aguilar, S Xu, L Huang, K Chinnaswamy, T Sleger, B Wang, ... Journal of Medicinal Chemistry 64 (14), 10333-10349, 2021 | 13 | 2021 |
| Atom Type Independent Modeling of the Conformational Energy of Benzylic, Allylic, and other Bonds Adjacent to Conjugated Systems C Champion, SJ Barigye, W Wei, Z Liu, P Labute, N Moitessier Journal of chemical information and modeling 59 (11), 4750-4763, 2019 | 9 | 2019 |
| Use of Extended-Hückel Descriptors for Rapid and Accurate Predictions of Conjugated Torsional Energy Barriers W Wei, C Champion, SJ Barigye, Z Liu, P Labute, N Moitessier Journal of Chemical Information and Modeling 60 (7), 3534-3545, 2020 | 7 | 2020 |
| Cytochrome P450 aromatic oxidation: A simple model for reactive metabolites prediction A Tomberg, J Pottel, Z Liu, C Corbeil, P Labute, N Moitessier ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 250, 2015 | | 2015 |
| 51 Platinum (II) phenanthroimidazoles with “clicked” side chains as selective G-quadruplex DNA binders KJ Castor, J Akhoury, Z Liu, M Hancock, A Mittermaier, N Moitessier, ... Journal of Biomolecular Structure and Dynamics 31 (sup1), 31-32, 2013 | | 2013 |
| Discovery of M-1121 as an Orally Active Covalent Inhibitor of Menin-MLL Interaction Capable of Achieving Complete and Long-Lasting Tumor Regression | | |
| Structure-Based Discovery of SD-36 as a Potent, Selective and Efficacious PROTAC Degrader of STAT3 Protein | | |
