Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, β cell dysfunction, and type 2 diabetes CY Zhang, G Baffy, P Perret, S Krauss, O Peroni, D Grujic, T Hagen, ... Cell 105 (6), 745-755, 2001 | 1206 | 2001 |
Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1α T Hagen, CT Taylor, F Lam, S Moncada Science 302 (5652), 1975-1978, 2003 | 868 | 2003 |
Energy metabolism in uncoupling protein 3 gene knockout mice AJ Vidal-Puig, D Grujic, CY Zhang, T Hagen, O Boss, Y Ido, A Szczepanik, ... Journal of Biological Chemistry 275 (21), 16258-16266, 2000 | 802 | 2000 |
Uncoupling proteins 2 and 3: potential regulators of mitochondrial energy metabolism. O Boss, T Hagen, BB Lowell Diabetes 49 (2), 143-156, 2000 | 552 | 2000 |
Stabilization of hypoxia-inducible factor-1α protein in hypoxia occurs independently of mitochondrial reactive oxygen species production YL Chua, E Dufour, EP Dassa, P Rustin, HT Jacobs, CT Taylor, T Hagen Journal of Biological Chemistry 285 (41), 31277-31284, 2010 | 205 | 2010 |
Utilizing hydrogen sulfide as a novel anti‐cancer agent by targeting cancer glycolysis and p H imbalance ZW Lee, XY Teo, EYW Tay, CH Tan, T Hagen, PK Moore, LW Deng British journal of pharmacology 171 (18), 4322-4336, 2014 | 142 | 2014 |
Characterisation of the phosphorylation of β-catenin at the GSK-3 priming site Ser45 T Hagen, A Vidal-Puig Biochemical and biophysical research communications 294 (2), 324-328, 2002 | 138 | 2002 |
Inhibition of cellular respiration by endogenously produced carbon monoxide G D'Amico, F Lam, T Hagen, S Moncada Journal of cell science 119 (11), 2291-2298, 2006 | 135 | 2006 |
Expression and characterization of GSK-3 mutants and their effect on β-catenin phosphorylation in intact cells T Hagen, E Di Daniel, AA Culbert, AD Reith Journal of Biological Chemistry 277 (26), 23330-23335, 2002 | 134 | 2002 |
Assessment of uncoupling activity of uncoupling protein 3 using a yeast heterologous expression system CY Zhang, T Hagen, VK Mootha, LJ Slieker, BB Lowell FEBS letters 449 (2-3), 129-134, 1999 | 119 | 1999 |
Oxygen versus reactive oxygen in the regulation of HIF-1: the balance tips T Hagen Biochemistry research international 2012, 2012 | 115 | 2012 |
GSK-3 inhibition by adenoviral FRAT1 overexpression is neuroprotective and induces Tau dephosphorylation and β-catenin stabilisation without elevation of glycogen synthase activity AA Culbert, MJ Brown, S Frame, T Hagen, DAE Cross, B Bax, AD Reith Febs Letters 507 (3), 288-294, 2001 | 114 | 2001 |
Hydrogen sulfide donors in research and drug development ZJ Song, MY Ng, ZW Lee, W Dai, T Hagen, PK Moore, D Huang, LW Deng, ... MedChemComm 5 (5), 557-570, 2014 | 113 | 2014 |
Cloning and functional characterization of an uncoupling protein homolog in hummingbirds CR VIANNA, T HAGEN, CYU ZHANG, E BACHMAN, O BOSS, ... Physiological Genomics 5 (3), 137-145, 2001 | 108 | 2001 |
Oncogenic activation of the PI3K/Akt pathway promotes cellular glucose uptake by downregulating the expression of thioredoxin-interacting protein SY Hong, FX Yu, Y Luo, T Hagen Cellular signalling 28 (5), 377-383, 2016 | 101 | 2016 |
Substrate-mediated regulation of cullin neddylation EH Chew, T Hagen Journal of Biological Chemistry 282 (23), 17032-17040, 2007 | 99 | 2007 |
Thioredoxin-interacting protein (Txnip) gene expression: sensing oxidative phosphorylation status and glycolytic rate FX Yu, TF Chai, H He, T Hagen, Y Luo Journal of biological chemistry 285 (33), 25822-25830, 2010 | 94 | 2010 |
Characterization of cullin-based E3 ubiquitin ligases in intact mammalian cells—evidence for cullin dimerization EH Chew, T Poobalasingam, CJ Hawkey, T Hagen Cellular signalling 19 (5), 1071-1080, 2007 | 82 | 2007 |
Inhibition of mitochondrial respiration by the anticancer agent 2-methoxyestradiol T Hagen, G D’Amico, M Quintero, M Palacios-Callender, V Hollis, F Lam, ... Biochemical and biophysical research communications 322 (3), 923-929, 2004 | 81 | 2004 |
Inhibition of hypoxia-inducible factor-1α (HIF-1α) protein synthesis by DNA damage inducing agents JJW Lou, YL Chua, EH Chew, J Gao, M Bushell, T Hagen PloS one 5 (5), e10522, 2010 | 71 | 2010 |