| STAT3 signaling: anticancer strategies and challenges PA Johnston, JR Grandis Molecular interventions 11 (1), 18, 2011 | 499 | 2011 |
| The production of 3D tumor spheroids for cancer drug discovery S Sant, PA Johnston Drug Discovery Today: Technologies 23, 27-36, 2017 | 404 | 2017 |
| The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites S Pratt, RL Shepard, RA Kandasamy, PA Johnston, W Perry III, ... Molecular cancer therapeutics 4 (5), 855-863, 2005 | 294 | 2005 |
| gCap39, a calcium ion-and polyphosphoinositide-regulated actin capping protein FX Yu, PA Johnston, TC Südhof, HL Yin Science 250 (4986), 1413-1415, 1990 | 250 | 1990 |
| Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin α1-antitrypsin Z SJ Gosai, JH Kwak, CJ Luke, OS Long, DE King, KJ Kovatch, ... PloS one 5 (11), e15460, 2010 | 208 | 2010 |
| Cellular platforms for HTS: three case studies PA Johnston, PA Johnston Drug discovery today 7 (6), 353-363, 2002 | 199 | 2002 |
| Applications in in ovo technology PA Johnston, H Liu, T O'Connell, P Phelps, M Bland, J Tyczkowski, ... Poultry science 76 (1), 165-178, 1997 | 188 | 1997 |
| Mechanism of Ca2+ inhibition of inositol 1, 4, 5-trisphosphate (InsP3) binding to the cerebellar InsP3 receptor. GA Mignery, PA Johnston, TC Südhof Journal of Biological Chemistry 267 (11), 7450-7455, 1992 | 152 | 1992 |
| Development of a 384-well colorimetric assay to quantify hydrogen peroxide generated by the redox cycling of compounds in the presence of reducing agents PA Johnston, KM Soares, SN Shinde, CA Foster, TY Shun, HK Takyi, ... Assay and drug development technologies 6 (4), 505-518, 2008 | 129 | 2008 |
| HTS identifies novel and specific uncompetitive inhibitors of the two-component NS2B-NS3 proteinase of West Nile virus PA Johnston, J Phillips, TY Shun, S Shinde, JS Lazo, DM Huryn, ... Assay and drug development technologies 5 (6), 737-750, 2007 | 119 | 2007 |
| Profiling the NIH Small Molecule Repository for Compounds That Generate H2O2 by Redox Cycling in Reducing Environments KM Soares, N Blackmon, TY Shun, SN Shinde, HK Takyi, P Wipf, JS Lazo, ... Assay and drug development technologies 8 (2), 152-174, 2010 | 116 | 2010 |
| Redox cycling compounds generate H2O2 in HTS buffers containing strong reducing reagents—real hits or promiscuous artifacts? PA Johnston Current opinion in chemical biology 15 (1), 174-182, 2011 | 94 | 2011 |
| Two novel annexins from Drosophila melanogaster. Cloning, characterization, and differential expression in development. PA Johnston, MS Perin, GA Reynolds, SA Wasserman, TC Südhof Journal of Biological Chemistry 265 (19), 11382-11388, 1990 | 87 | 1990 |
| Alleged mosasaur bite marks on Late Cretaceous ammonites are limpet (patellogastropod) home scars T Kase, PA Johnston, A Seilacher, JB Boyce Geology 26 (10), 947-950, 1998 | 79 | 1998 |
| Production of uniform 3D microtumors in hydrogel microwell arrays for measurement of viability, morphology, and signaling pathway activation M Singh, DA Close, S Mukundan, PA Johnston, S Sant Assay and drug development technologies 13 (9), 570-583, 2015 | 76 | 2015 |
| Identifying actives from HTS data sets: practical approaches for the selection of an appropriate HTS data-processing method and quality control review TY Shun, JS Lazo, ER Sharlow, PA Johnston Journal of Biomolecular Screening 16 (1), 1-14, 2011 | 76 | 2011 |
| Secretion of proinflammatory cytokines and chemokines during amphotericin B exposure is mediated by coactivation of toll-like receptors 1 and 2 RR Razonable, M Henault, LN Lee, C Laethem, PA Johnston, HL Watson, ... Antimicrobial agents and chemotherapy 49 (4), 1617-1621, 2005 | 75 | 2005 |
| Development and optimization of high-throughput in vitro protein phosphatase screening assays MB Tierno, PA Johnston, C Foster, JJ Skoko, SN Shinde, TY Shun, ... Nature protocols 2 (5), 1134-1144, 2007 | 74 | 2007 |
| Paleoculicis minututs (Diptera: Culicidae) n. Gen., n. Sp., from Cretaceous Canadian amber, with a summary of described fossil mosquitoes GO Poinar, TJ Zavortinik, T Pike, PA Johnston Acta Geologica Hispanica, 119-130, 2000 | 68 | 2000 |
| Requirements, features, and performance of high content screening platforms AH Gough, PA Johnston High Content Screening: A Powerful Approach to Systems Cell Biology and Drug …, 2006 | 61 | 2006 |
