|Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds|
D Huangfu, R Maehr, W Guo, A Eijkelenboom, M Snitow, AE Chen, ...
Nature biotechnology 26 (7), 795-797, 2008
|Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2|
D Huangfu, K Osafune, R Maehr, W Guo, A Eijkelenboom, S Chen, ...
Nature biotechnology 26 (11), 1269, 2008
|Generation of pluripotent stem cells from patients with type 1 diabetes|
R Maehr, S Chen, M Snitow, T Ludwig, L Yagasaki, R Goland, RL Leibel, ...
Proceedings of the National Academy of Sciences 106 (37), 15768-15773, 2009
|A small molecule that directs differentiation of human ESCs into the pancreatic lineage|
S Chen, M Borowiak, JL Fox, R Maehr, K Osafune, L Davidow, K Lam, ...
Nature chemical biology 5 (4), 258, 2009
|The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc|
PL Greer, R Hanayama, BL Bloodgood, AR Mardinly, DM Lipton, ...
Cell 140 (5), 704-716, 2010
|Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells|
M Borowiak, R Maehr, S Chen, AE Chen, W Tang, JL Fox, SL Schreiber, ...
Cell stem cell 4 (4), 348-358, 2009
|Functional annotation of native enhancers with a Cas9–histone demethylase fusion|
NA Kearns, H Pham, B Tabak, RM Genga, NJ Silverstein, M Garber, ...
Nature methods 12 (5), 401-403, 2015
|SCF β-TRCP controls oncogenic transformation and neural differentiation through REST degradation|
TF Westbrook, G Hu, XL Ang, P Mulligan, NN Pavlova, A Liang, Y Leng, ...
Nature 452 (7185), 370-374, 2008
|Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal|
KK Niakan, H Ji, R Maehr, SA Vokes, KT Rodolfa, RI Sherwood, ...
Genes & development 24 (3), 312-326, 2010
|Differential dependence of CD4+ CD25+ regulatory and natural killer-like T cells on signals leading to NF-κB activation|
M Schmidt-Supprian, J Tian, EP Grant, M Pasparakis, R Maehr, H Ovaa, ...
Proceedings of the National Academy of Sciences 101 (13), 4566-4571, 2004
|Analysis of protease activity in live antigen-presenting cells shows regulation of the phagosomal proteolytic contents during dendritic cell activation|
AM Lennon-Duménil, AH Bakker, R Maehr, E Fiebiger, HS Overkleeft, ...
The Journal of experimental medicine 196 (4), 529-540, 2002
|Cas9 effector-mediated regulation of transcription and differentiation in human pluripotent stem cells|
NA Kearns, RMJ Genga, MS Enuameh, M Garber, SA Wolfe, R Maehr
Development 141 (1), 219-223, 2014
|The mouse polyubiquitin gene UbC is essential for fetal liver development, cell‐cycle progression and stress tolerance|
KY Ryu, R Maehr, CA Gilchrist, MA Long, DM Bouley, B Mueller, ...
The EMBO journal 26 (11), 2693-2706, 2007
|Live imaging of cysteine-cathepsin activity reveals dynamics of focal inflammation, angiogenesis, and polyp growth|
E Gounaris, CH Tung, C Restaino, R Maehr, R Kohler, JA Joyce, ...
PloS one 3 (8), 2008
|Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes|
JAB Babon, ME DeNicola, DM Blodgett, I Crèvecoeur, TS Buttrick, ...
Nature medicine 22 (12), 1482, 2016
|De novo formation of insulin-producing “neo-β cell islets” from intestinal crypts|
YJ Chen, SR Finkbeiner, D Weinblatt, MJ Emmett, F Tameire, M Yousefi, ...
Cell reports 6 (6), 1046-1058, 2014
|Asparagine endopeptidase is not essential for class II MHC antigen presentation but is required for processing of cathepsin L in mice|
R Maehr, HC Hang, JD Mintern, YM Kim, A Cuvillier, M Nishimura, ...
The Journal of Immunology 174 (11), 7066-7074, 2005
|Wnt signaling specifies and patterns intestinal endoderm|
RI Sherwood, R Maehr, EO Mazzoni, DA Melton
Mechanisms of development 128 (7-10), 387-400, 2011
|Invariant chain controls the activity of extracellular cathepsin L|
E Fiebiger, R Maehr, J Villadangos, E Weber, A Erickson, E Bikoff, ...
The Journal of experimental medicine 196 (9), 1263-1270, 2002
|Cathepsin L is essential for onset of autoimmune diabetes in NOD mice|
R Maehr, JD Mintern, AE Herman, AM Lennon-Duménil, D Mathis, ...
The Journal of clinical investigation 115 (10), 2934-2943, 2005