Patrick McMullen
Patrick McMullen
Lurie Children's
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Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating …
P Godoy, NJ Hewitt, U Albrecht, ME Andersen, N Ansari, S Bhattacharya, ...
Archives of toxicology 87, 1315-1530, 2013
Identification of a tissue-selective heat shock response regulatory network
E Guisbert, DM Czyz, K Richter, PD McMullen, RI Morimoto
PLoS genetics 9 (4), e1003466, 2013
A map of the PPARα transcription regulatory network for primary human hepatocytes
PD McMullen, S Bhattacharya, CG Woods, B Sun, K Yarborough, ...
Chemico-biological interactions 209, 14-24, 2014
Applying'omics technologies in chemicals risk assessment: Report of an ECETOC workshop
R Buesen, BN Chorley, B da Silva Lima, G Daston, L Deferme, T Ebbels, ...
Regulatory Toxicology and Pharmacology 91, S3-S13, 2017
The human toxome project
M Bouhifd, ME Andersen, C Baghdikian, K Boekelheide, KM Crofton, ...
Altex 32 (2), 112, 2015
Modeling drug-and chemical-induced hepatotoxicity with systems biology approaches
S Bhattacharya, LKM Shoda, Q Zhang, CG Woods, BA Howell, SQ Siler, ...
Frontiers in physiology 3, 462, 2012
Profiling dose-dependent activation of p53-mediated signaling pathways by chemicals with distinct mechanisms of DNA damage
RA Clewell, B Sun, Y Adeleye, P Carmichael, A Efremenko, PD McMullen, ...
Toxicological sciences 142 (1), 56-73, 2014
Developing context appropriate toxicity testing approaches using new alternative methods (NAMs)
ME Andersen, PD McMullen, MB Phillips, M Yoon, SN Pendse, ...
ALTEX-Alternatives to animal experimentation 36 (4), 523-534, 2019
Macro-level Modeling of the Response of C. elegans Reproduction to Chronic Heat Stress
PD McMullen, EZ Aprison, PB Winter, LAN Amaral, RI Morimoto, ...
PLoS computational biology 8 (1), e1002338, 2012
Evaluating opportunities for advancing the use of alternative methods in risk assessment through the development of fit-for-purpose in vitro assays
PD McMullen, ME Andersen, B Cholewa, HJ Clewell III, KM Dunnick, ...
Toxicology in Vitro 48, 310-317, 2018
MYC is an early response regulator of human adipogenesis in adipose stem cells
C Deisenroth, MB Black, S Pendse, L Pluta, SM Witherspoon, ...
PLoS One 9 (12), e114133, 2014
Application of a combined aggregate exposure pathway and adverse outcome pathway (AEP-AOP) approach to inform a cumulative risk assessment: A case study with phthalates
RA Clewell, JA Leonard, CI Nicolas, JL Campbell, M Yoon, AY Efremenko, ...
Toxicology in vitro 66, 104855, 2020
Assessing molecular initiating events (MIEs), key events (KEs) and modulating factors (MFs) for styrene responses in mouse lungs using whole genome gene expression profiling …
ME Andersen, G Cruzan, MB Black, SN Pendse, D Dodd, JS Bus, ...
Toxicology and applied pharmacology 335, 28-40, 2017
Multiple receptors shape the estrogen response pathway and are critical considerations for the future of in vitro-based risk assessment efforts
MM Miller, PD McMullen, ME Andersen, RA Clewell
Critical reviews in toxicology 47 (7), 570-586, 2017
Information-dependent enrichment analysis reveals time-dependent transcriptional regulation of the estrogen pathway of toxicity
SN Pendse, A Maertens, M Rosenberg, D Roy, RA Fasani, ...
Archives of Toxicology 91, 1749-1762, 2017
Identifying qualitative differences in PPARα signaling networks in human and rat hepatocytes and their significance for next generation chemical risk assessment methods
PD McMullen, S Bhattacharya, CG Woods, SN Pendse, MT McBride, ...
Toxicology in Vitro 64, 104463, 2020
Combining transcriptomics and PBPK modeling indicates a primary role of hypoxia and altered circadian signaling in dichloromethane carcinogenicity in mouse lung and liver
ME Andersen, MB Black, JL Campbell, SN Pendse, HJ Clewell III, ...
Toxicology and Applied Pharmacology 332, 149-158, 2017
Addressing systematic inconsistencies between in vitro and in vivo transcriptomic mode of action signatures
PD McMullen, SN Pendse, MB Black, K Mansouri, S Haider, ME Andersen, ...
Toxicology in Vitro 58, 1-12, 2019
A toxicogenomic approach for the risk assessment of the food contaminant acetamide
R Nault, B Bals, F Teymouri, MB Black, ME Andersen, PD McMullen, ...
Toxicology and applied pharmacology 388, 114872, 2020
Population life-course exposure to health effects model (PLETHEM): An R package for PBPK modeling
SN Pendse, A Efremenko, CE Hack, M Moreau, P Mallick, M Dzierlenga, ...
Computational Toxicology 13, 100115, 2020
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