| Cellular uptake and trafficking of antisense oligonucleotides ST Crooke, S Wang, TA Vickers, W Shen, X Liang Nature biotechnology 35 (3), 230-237, 2017 | 487 | 2017 |
| Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index W Shen, CL De Hoyos, MT Migawa, TA Vickers, H Sun, A Low, TA Bell III, ... Nature biotechnology 37 (6), 640-650, 2019 | 241 | 2019 |
| Identification and characterization of intracellular proteins that bind oligonucleotides with phosphorothioate linkages X Liang, H Sun, W Shen, ST Crooke Nucleic acids research 43 (5), 2927-2945, 2015 | 188 | 2015 |
| Translation efficiency of mRNAs is increased by antisense oligonucleotides targeting upstream open reading frames XH Liang, W Shen, H Sun, MT Migawa, TA Vickers, ST Crooke Nature biotechnology 34 (8), 875-880, 2016 | 182 | 2016 |
| Genetic polymorphism analysis of CYP2C19 in Chinese Han populations from different geographic areas of mainland China L Chen, S Qin, J Xie, J Tang, L Yang, W Shen, X Zhao, J Du, G He, ... Future Medicine Ltd 9 (6), 691-702, 2008 | 119 | 2008 |
| 2′-Fluoro-modified phosphorothioate oligonucleotide can cause rapid degradation of P54nrb and PSF W Shen, X Liang, H Sun, ST Crooke Nucleic acids research 43 (9), 4569-4578, 2015 | 113 | 2015 |
| Antisense oligonucleotides targeting translation inhibitory elements in 5′ UTRs can selectively increase protein levels X Liang, H Sun, W Shen, S Wang, J Yao, MT Migawa, HH Bui, SS Damle, ... Nucleic acids research 45 (16), 9528-9546, 2017 | 98 | 2017 |
| Phosphorothioate oligonucleotides can displace NEAT1 RNA and form nuclear paraspeckle-like structures W Shen, X Liang, ST Crooke Nucleic acids research 42 (13), 8648-8662, 2014 | 98 | 2014 |
| Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins MT Migawa, W Shen, WB Wan, G Vasquez, ME Oestergaard, A Low, ... Nucleic acids research 47 (11), 5465-5479, 2019 | 89 | 2019 |
| TCP1 complex proteins interact with phosphorothioate oligonucleotides and can co-localize in oligonucleotide-induced nuclear bodies in mammalian cells X Liang, W Shen, H Sun, TP Prakash, ST Crooke Nucleic acids research 42 (12), 7819-7832, 2014 | 89 | 2014 |
| Acute hepatotoxicity of 2′ fluoro-modified 5–10–5 gapmer phosphorothioate oligonucleotides in mice correlates with intracellular protein binding and the loss of DBHS proteins W Shen, CL De Hoyos, H Sun, TA Vickers, X Liang, ST Crooke Nucleic acids research 46 (5), 2204-2217, 2018 | 85 | 2018 |
| Understanding the effect of controlling phosphorothioate chirality in the DNA gap on the potency and safety of gapmer antisense oligonucleotides ME Østergaard, CL De Hoyos, WB Wan, W Shen, A Low, A Berdeja, ... Nucleic Acids Research 48 (4), 1691-1700, 2020 | 73 | 2020 |
| Systematic polymorphism analysis of the CYP2D6 gene in four different geographical Han populations in mainland China S Qin, L Shen, A Zhang, J Xie, W Shen, L Chen, J Tang, Y Xiong, L Yang, ... Genomics 92 (3), 152-158, 2008 | 73 | 2008 |
| Hsp90 protein interacts with phosphorothioate oligonucleotides containing hydrophobic 2′-modifications and enhances antisense activity XH Liang, W Shen, H Sun, GA Kinberger, TP Prakash, JG Nichols, ... Nucleic Acids Research 44 (8), 3892-3907, 2016 | 70 | 2016 |
| Dynamic nucleoplasmic and nucleolar localization of mammalian RNase H1 in response to RNAP I transcriptional R-loops W Shen, H Sun, CL De Hoyos, JK Bailey, X Liang, ST Crooke Nucleic acids research 45 (18), 10672-10692, 2017 | 67 | 2017 |
| Nucleic acid binding proteins affect the subcellular distribution of phosphorothioate antisense oligonucleotides JK Bailey, W Shen, X Liang, ST Crooke Nucleic acids research 45 (18), 10649-10671, 2017 | 58 | 2017 |
| A recombination hot spot in HIV-1 contains guanosine runs that can form a G-quartet structure and promote strand transfer in vitro W Shen, L Gao, M Balakrishnan, RA Bambara Journal of biological chemistry 284 (49), 33883-33893, 2009 | 51 | 2009 |
| COPII vesicles can affect the activity of antisense oligonucleotides by facilitating the release of oligonucleotides from endocytic pathways X Liang, H Sun, JG Nichols, N Allen, S Wang, TA Vickers, W Shen, ... Nucleic acids research 46 (19), 10225-10245, 2018 | 33 | 2018 |
| HIV-1 nucleocapsid protein increases strand transfer recombination by promoting dimeric G-quartet formation W Shen, RJ Gorelick, RA Bambara Journal of Biological Chemistry 286 (34), 29838-29847, 2011 | 33 | 2011 |
| Depletion of NEAT1 lncRNA attenuates nucleolar stress by releasing sequestered P54nrb and PSF to facilitate c-Myc translation W Shen, X Liang, H Sun, CL De Hoyos, ST Crooke PLoS One 12 (3), e0173494, 2017 | 31 | 2017 |
