Raphael Kopan
Cited by
Cited by
The canonical Notch signaling pathway: unfolding the activation mechanism
R Kopan, MXG Ilagan
Cell 137 (2), 216-233, 2009
A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain
B De Strooper, W Annaert, P Cupers, P Saftig, K Craessaerts, JS Mumm, ...
Nature 398 (6727), 518-522, 1999
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
EH Schroeter, JA Kisslinger, R Kopan
Nature 393 (6683), 382-386, 1998
Signalling downstream of activated mammalian Notch
S Jarriault, C Brou, F Logeat, EH Schroeter, R Kopan, A Israel
Nature 377 (6547), 355-358, 1995
Notch signaling: from the outside in
JS Mumm, R Kopan
Developmental biology 228 (2), 151-165, 2000
A ligand-induced extracellular cleavage regulates γ-secretase-like proteolytic activation of Notch1
JS Mumm, EH Schroeter, MT Saxena, A Griesemer, X Tian, DJ Pan, ...
Molecular cell 5 (2), 197-206, 2000
NOTCH AND PRESENILIN: Regulated Intramembrane Proteolysis Links Development and Degeneration
D Selkoe, R Kopan
Annual review of neuroscience 26 (1), 565-597, 2003
AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch
JS Lee, M Cella, KG McDonald, C Garlanda, GD Kennedy, M Nukaya, ...
Nature immunology 13 (2), 144-151, 2012
Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development
F Costantini, R Kopan
Developmental cell 18 (5), 698-712, 2010
γ-Secretase: proteasome of the membrane?
R Kopan, MXG Ilagan
Nature reviews Molecular cell biology 5 (6), 499-504, 2004
Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation
MJ Hilton, X Tu, X Wu, S Bai, H Zhao, T Kobayashi, HM Kronenberg, ...
Nature medicine 14 (3), 306-314, 2008
Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.
R Kopan, EH Schroeter, H Weintraub, JS Nye
Proceedings of the National Academy of Sciences 93 (4), 1683-1688, 1996
The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD
R Kopan, JS Nye, H Weintraub
Development 120 (9), 2385-2396, 1994
Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of α-synuclein, and apoptotic cell death in aged mice
Y Tong, H Yamaguchi, E Giaime, S Boyle, R Kopan, RJ Kelleher III, ...
Proceedings of the National Academy of Sciences 107 (21), 9879-9884, 2010
Human papillomavirus type 16 alters human epithelial cell differentiation in vitro.
DJ McCance, R Kopan, E Fuchs, LA Laimins
Proceedings of the National Academy of Sciences 85 (19), 7169-7173, 1988
Dll1-and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells
L Pellegrinet, V Rodilla, Z Liu, S Chen, U Koch, L Espinosa, KH Kaestner, ...
Gastroenterology 140 (4), 1230-1240. e7, 2011
Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens
AT Satpathy, CG Briseņo, JS Lee, D Ng, NA Manieri, W Kc, X Wu, ...
Nature immunology 14 (9), 937-948, 2013
Intramembrane proteolysis: theme and variations
MS Wolfe, R Kopan
Science 305 (5687), 1119-1123, 2004
F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation
QD Hu, BT Ang, M Karsak, WP Hu, XY Cui, T Duka, Y Takeda, W Chia, ...
Cell 115 (2), 163-175, 2003
Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1
SS Huppert, A Le, EH Schroeter, JS Mumm, MT Saxena, LA Milner, ...
Nature 405 (6789), 966-970, 2000
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