Nicholas Topley
Nicholas Topley
Cardiff University School of Medicine
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Morphologic changes in the peritoneal membrane of patients with renal disease
JD Williams, KJ Craig, N Topley, C Von Ruhland, M Fallon, GR Newman, ...
Journal of the American Society of Nephrology 13 (2), 470-479, 2002
Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation
SM Hurst, TS Wilkinson, RM McLoughlin, S Jones, S Horiuchi, ...
Immunity 14 (6), 705-714, 2001
The soluble interleukin 6 receptor: mechanisms of production and implications in disease
SA Jones, S Horiuchi, N Topley, N YAMAMOTO, GM Fuller
The FASEB Journal 15 (1), 43-58, 2001
The Euro-Balance Trial: the effect of a new biocompatible peritoneal dialysis fluid (balance) on the peritoneal membrane
JD Williams, N Topley, KJ Craig, RK Mackenzie, M Pischetsrieder, C Lage, ...
Kidney international 66 (1), 408-418, 2004
Encapsulating peritoneal sclerosis: definition, etiology, diagnosis, and treatment
Y Kawaguchi, H Kawanishi, S Mujais, N Topley, DG Oreopoulos
Peritoneal Dialysis International 20 (4_suppl), 43-55, 2000
IL-6 regulates neutrophil trafficking during acute inflammation via STAT3
CA Fielding, RM McLoughlin, L McLeod, CS Colmont, M Najdovska, ...
The journal of immunology 181 (3), 2189-2195, 2008
IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation
RM McLoughlin, BJ Jenkins, D Grail, AS Williams, CA Fielding, CR Parker, ...
Proceedings of the National Academy of Sciences 102 (27), 9589-9594, 2005
Interleukin 1-α and tumor necrosis factor-α induce oxygen radical production in mesangial cells
HH Radeke, B Meier, N Topley, J Flöge, GG Habermehl, K Resch
Kidney international 37 (2), 767-775, 1990
Interleukin-6 signaling drives fibrosis in unresolved inflammation
CA Fielding, GW Jones, RM McLoughlin, L McLeod, VJ Hammond, ...
Immunity 40 (1), 40-50, 2014
Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-β signaling
BJ Jenkins, D Grail, T Nheu, M Najdovska, B Wang, P Waring, M Inglese, ...
Nature medicine 11 (8), 845-852, 2005
Interplay between IFN-γ and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation
RM McLoughlin, J Witowski, RL Robson, TS Wilkinson, SM Hurst, ...
The Journal of clinical investigation 112 (4), 598-607, 2003
Soluble IL-6 receptor governs IL-6 activity in experimental arthritis: blockade of arthritis severity by soluble glycoprotein 130
MA Nowell, PJ Richards, S Horiuchi, N Yamamoto, S Rose-John, ...
The Journal of Immunology 171 (6), 3202-3209, 2003
The pathophysiology of the peritoneal membrane
O Devuyst, PJ Margetts, N Topley
Journal of the American Society of Nephrology 21 (7), 1077-1085, 2010
Human peritoneal mesothelial cells synthesize interleukin-6: induction by IL-1β and TNFα
N Topley, A Jörres, W Luttmann, MM Petersen, MJ Lang, KH Thierauch, ...
Kidney international 43 (1), 226-233, 1993
Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis
MA Nowell, AS Williams, SA Carty, J Scheller, AJ Hayes, GW Jones, ...
The Journal of Immunology 182 (1), 613-622, 2009
Regulation of pre–B cell colony‐enhancing factor by STAT‐3–dependent interleukin‐6 trans‐signaling: Implications in the pathogenesis of rheumatoid arthritis
MA Nowell, PJ Richards, CA Fielding, S Ognjanovic, N Topley, ...
Arthritis & Rheumatism: Official Journal of the American College of …, 2006
Interleukin-6 regulation of transforming growth factor (TGF)-β receptor compartmentalization and turnover enhances TGF-β1 signaling
XL Zhang, N Topley, T Ito, A Phillips
Journal of Biological Chemistry 280 (13), 12239-12245, 2005
Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells
GW Jones, RM McLoughlin, VJ Hammond, CR Parker, JD Williams, ...
The journal of immunology 184 (4), 2130-2139, 2010
The effect of dialysate on peritoneal phagocyte oxidative metabolism
N Topley, HMM Alobaidi, M Davies, GA Coles, JD Williams, D Lloyd
Kidney international 34 (3), 404-411, 1988
TPA-induced differentiation and adhesion of U937 cells: changes in ultrastructure, cytoskeletal organization and expression of cell surface antigens.
R Hass, H Bartels, N Topley, M Hadam, L Köhler, M Goppelt-Strübe, ...
European journal of cell biology 48 (2), 282-293, 1989
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