Shengdar Q. Tsai
Shengdar Q. Tsai
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Efficient genome editing in zebrafish using a CRISPR-Cas system
WY Hwang, Y Fu, D Reyon, ML Maeder, SQ Tsai, JD Sander, ...
Nature biotechnology 31 (3), 227-229, 2013
High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects
BP Kleinstiver, V Pattanayak, MS Prew, SQ Tsai, NT Nguyen, Z Zheng, ...
Nature 529 (7587), 490-495, 2016
GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases
SQ Tsai, Z Zheng, NT Nguyen, M Liebers, VV Topkar, V Thapar, ...
Nature biotechnology 33 (2), 187, 2015
FLASH assembly of TALENs for high-throughput genome editing
D Reyon, SQ Tsai, C Khayter, JA Foden, JD Sander, JK Joung
Nature biotechnology 30 (5), 460, 2012
Engineered CRISPR-Cas9 nucleases with altered PAM specificities
BP Kleinstiver, MS Prew, SQ Tsai, VV Topkar, NT Nguyen, Z Zheng, ...
Nature 523 (7561), 481-485, 2015
Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing
SQ Tsai, N Wyvekens, C Khayter, JA Foden, V Thapar, D Reyon, ...
Nature biotechnology 32 (6), 569, 2014
Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins
ML Maeder, JF Angstman, ME Richardson, SJ Linder, VM Cascio, ...
Nature biotechnology 31 (12), 1137, 2013
Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition
BP Kleinstiver, MS Prew, SQ Tsai, NT Nguyen, VV Topkar, Z Zheng, ...
Nature biotechnology 33 (12), 1293-1298, 2015
Toddler: an embryonic signal that promotes cell movement via Apelin receptors
A Pauli, ML Norris, E Valen, GL Chew, JA Gagnon, S Zimmerman, ...
Science 343 (6172), 1248636, 2014
Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells
BP Kleinstiver, SQ Tsai, MS Prew, NT Nguyen, MM Welch, JM Lopez, ...
Nature biotechnology 34 (8), 869, 2016
Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells
J Liao, R Karnik, H Gu, MJ Ziller, K Clement, AM Tsankov, V Akopian, ...
Nature genetics 47 (5), 469, 2015
Highly efficient generation of heritable zebrafish gene mutations using homo-and heterodimeric TALENs
L Cade, D Reyon, WY Hwang, SQ Tsai, S Patel, C Khayter, JK Joung, ...
Nucleic acids research 40 (16), 8001-8010, 2012
Defining and improving the genome-wide specificities of CRISPR–Cas9 nucleases
SQ Tsai, JK Joung
Nature Reviews Genetics 17 (5), 300, 2016
CIRCLE-seq: a highly sensitive in vitro screen for genome-wide CRISPR–Cas9 nuclease off-targets
SQ Tsai, NT Nguyen, J Malagon-Lopez, VV Topkar, MJ Aryee, JK Joung
Nature methods 14 (6), 607, 2017
Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity
JP Guilinger, V Pattanayak, D Reyon, SQ Tsai, JD Sander, JK Joung, ...
Nature methods 11 (4), 429, 2014
Annotation of the Affymetrix1 porcine genome microarray
S Tsai, JP Cassady, BA Freking, DJ Nonneman, GA Rohrer, JA Piedrahita
Animal genetics 37 (4), 423-424, 2006
Dimeric CRISPR RNA-guided FokI-dCas9 nucleases directed by truncated gRNAs for highly specific genome editing
N Wyvekens, VV Topkar, C Khayter, JK Joung, SQ Tsai
Human gene therapy 26 (7), 425-431, 2015
In vivo CRISPR editing with no detectable genome-wide off-target mutations
P Akcakaya, ML Bobbin, JA Guo, J Malagon-Lopez, K Clement, SP Garcia, ...
Nature 561 (7723), 416-419, 2018
Genetic inactivation of CD33 in hematopoietic stem cells to enable CAR T cell immunotherapy for acute myeloid leukemia
MY Kim, KR Yu, SS Kenderian, M Ruella, S Chen, TH Shin, AA Aljanahi, ...
Cell 173 (6), 1439-1453. e19, 2018
Characterization of conserved and nonconserved imprinted genes in swine
SR Bischoff, S Tsai, N Hardison, AA Motsinger-Reif, BA Freking, ...
Biology of reproduction 81 (5), 906-920, 2009
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