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Ramulu Poddutoori, Ph.D.
Ramulu Poddutoori, Ph.D.
Syngene International Ltd
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Year
Design, synthesis, and evaluation of new noncross-linking pyrrolobenzodiazepine dimers with efficient DNA binding ability and potent antitumor activity
A Kamal, G Ramesh, N Laxman, P Ramulu, O Srinivas, K Neelima, ...
Journal of medicinal chemistry 45 (21), 4679-4688, 2002
1832002
Process for the preparation of antitumor agents
A Kamal, CL Nallan, R Gujjar, R Poddutoori, S Olepu
US Patent 6,362,331, 2002
1052002
Non-cross-linking pyrrolo [2, 1-c][1, 4] benzodiazepines and process thereof
A Kamal, G Ramesh, O Srinivas, P Ramulu
US Patent 6,884,799, 2005
1042005
Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-acridone/acridine hybrids as potential DNA-binding agents
A Kamal, O Srinivas, P Ramulu, G Ramesh, PP Kumar
Bioorganic & medicinal chemistry letters 14 (15), 4107-4111, 2004
662004
Synthesis of new benzimidazole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates with efficient DNA-binding affinity and potent cytotoxicity
A Kamal, PP Kumar, K Sreekanth, BN Seshadri, P Ramulu
Bioorganic & medicinal chemistry letters 18 (8), 2594-2598, 2008
652008
Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine–benzimidazole conjugates with remarkable DNA-binding affinity
A Kamal, P Ramulu, O Srinivas, G Ramesh, PP Kumar
Bioorganic & medicinal chemistry letters 14 (18), 4791-4794, 2004
522004
Synthesis of novel C2 and C2–C8 linked pyrrolo[2,1-c][1,4]benzodiazepine-naphthalimide hybrids as DNA-binding agents
A Kamal, O Srinivas, P Ramulu, G Ramesh, PP Kumar
Bioorganic & medicinal chemistry letters 13 (20), 3577-3581, 2003
512003
Synthesis and antitumour activity of pyrene-linked pyrrolo [2, 1-c], benzodiazepine hybrids
A Kamal, G Ramesh, O Srinivas, P Ramulu
Bioorganic & medicinal chemistry letters 14 (2), 471-474, 2004
502004
Design and synthesis of novel chrysene-linked pyrrolo[2,1-c][1,4]-benzodiazepine hybrids as potential DNA-binding agents
A Kamal, G Ramesh, P Ramulu, O Srinivas, T Rehana, G Sheelu
Bioorganic & medicinal chemistry letters 13 (20), 3451-3454, 2003
442003
Catalytic and ligand-binding characteristics of Plasmodium falciparum serine hydroxymethyltransferase
CKT Pang, JH Hunter, R Gujjar, R Podutoori, J Bowman, DG Mudeppa, ...
Molecular and biochemical parasitology 168 (1), 74-83, 2009
362009
Synthesis of C-8 methanesulphonate substituted pyrrolobenzodiazepines as potential antitumour agents
A Kamal, P Ramulu, O Srinivas, G Ramesh
Bioorganic & medicinal chemistry letters 13 (20), 3517-3519, 2003
292003
Synthesis of C-8 Alkylamino substituted pyrrolo[2,1-c][1,4]benzodiazepines as potential anti-Cancer agents
A Kamal, N Laxman, G Ramesh, O Srinivas, P Ramulu
Bioorganic & medicinal chemistry letters 12 (15), 1917-1919, 2002
262002
Synthesis and DNA-binding affinity of A-C8/C-C2 alkoxyamido-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers
A Kamal, P Ramulu, O Srinivas, G Ramesh
Bioorganic & medicinal chemistry letters 13 (22), 3955-3958, 2003
252003
Design, synthesis, and evaluation of mixed imine–amine pyrrolobenzodiazepine dimers with efficient DNA binding affinity and potent cytotoxicity
A Kamal, G Ramesh, O Srinivas, P Ramulu, N Laxman, T Rehana, ...
Bioorganic & medicinal chemistry 12 (20), 5427-5436, 2004
212004
Synthesis and DNA binding affinity of novel A-C8/C-C2-exo unsaturated alkoxyamido-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers
A Kamal, O Srinivas, P Ramulu, G Ramesh, PP Kumar, MS Kumar
Bioorganic & medicinal chemistry 12 (16), 4337-4350, 2004
202004
Modulators of sphingosine phosphate receptors
E Roberts, H Rosen, S Brown, MA Guerrero, X Peng, R Poddutoori
US Patent 8,796,318, 2014
192014
Compounds and compositions as inhibitors of MEK
MG Bock, H Moebitz, SK Panigrahi, R Poddutoori, S Samajdar
US Patent 9,227,969, 2016
182016
Discovery, design and synthesis of a selective S1P(3) receptor allosteric agonist
RE Guerrero M, Poddutoori R, Urbano M, Peng X, Spicer TP, Chase PS, Hodder ...
Bioorg Med Chem Lett 1 (23), 6436, 2013
18*2013
A protecting group-free synthesis of deazathiamine: A step toward inhibitor design
H Zhao, LPS de Carvalho, C Nathan, O Ouerfelli
Bioorganic & medicinal chemistry letters 20 (22), 6472-6474, 2010
182010
C8—linked pyrrolo [2, 1-c][1, 4] benzodiazepine-acridone/acridine hybrids
A Kamal, S Olepu, R Poddutoori, R Gujjar, PK Pogula
US Patent 7,056,913, 2006
152006
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