| The SLUG zinc-finger protein represses E-cadherin in breast cancer KM Hajra, DYS Chen, ER Fearon Cancer research 62 (6), 1613-1618, 2002 | 1299 | 2002 |
| Proteomic analysis reveals hyperactivation of the mammalian target of rapamycin pathway in neurofibromatosis 1–associated human and mouse brain tumors B Dasgupta, Y Yi, DY Chen, JD Weber, DH Gutmann Cancer research 65 (7), 2755-2760, 2005 | 349 | 2005 |
| Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression S Takeda, DY Chen, TD Westergard, JK Fisher, JA Rubens, S Sasagawa, ... Genes & development 20 (17), 2397-2409, 2006 | 196 | 2006 |
| A general approach for detecting expressed mutations in AML cells using single cell RNA-sequencing AA Petti, SR Williams, CA Miller, IT Fiddes, SN Srivatsan, DY Chen, ... Nature communications 10 (1), 3660, 2019 | 184 | 2019 |
| T cell characteristics associated with toxicity to immune checkpoint blockade in patients with melanoma AX Lozano, AA Chaudhuri, A Nene, A Bacchiocchi, N Earland, MD Vesely, ... Nature medicine 28 (2), 353-362, 2022 | 147 | 2022 |
| The p53-cathepsin axis cooperates with ROS to activate programmed necrotic death upon DNA damage HC Tu, D Ren, GX Wang, DY Chen, TD Westergard, H Kim, S Sasagawa, ... Proceedings of the National Academy of Sciences 106 (4), 1093-1098, 2009 | 121 | 2009 |
| A metabolic synthetic lethal strategy with arginine deprivation and chloroquine leads to cell death in ASS1-deficient sarcomas GR Bean, JC Kremer, BC Prudner, AD Schenone, JC Yao, MB Schultze, ... Cell death & disease 7 (10), e2406-e2406, 2016 | 86 | 2016 |
| Taspase1 functions as a non-oncogene addiction protease that coordinates cancer cell proliferation and apoptosis DY Chen, H Liu, S Takeda, HC Tu, S Sasagawa, BA Van Tine, D Lu, ... Cancer research 70 (13), 5358-5367, 2010 | 53 | 2010 |
| A pharmacologic inhibitor of the protease Taspase1 effectively inhibits breast and brain tumor growth DY Chen, Y Lee, BA Van Tine, AC Searleman, TD Westergard, H Liu, ... Cancer research 72 (3), 736-746, 2012 | 49 | 2012 |
| Design, syntheses, and evaluation of Taspase1 inhibitors JT Lee, DY Chen, Z Yang, AD Ramos, JJD Hsieh, M Bogyo Bioorganic & medicinal chemistry letters 19 (17), 5086-5090, 2009 | 47 | 2009 |
| Remethylation of Dnmt3a−/− hematopoietic cells is associated with partial correction of gene dysregulation and reduced myeloid skewing S Ketkar, AM Verdoni, AM Smith, CV Bangert, ER Leight, DY Chen, ... Proceedings of the National Academy of Sciences 117 (6), 3123-3134, 2020 | 31 | 2020 |
| Extensive tumoral melanosis associated with ipilimumab-treated melanoma K Staser, D Chen, J Solus, A Schaffer, L Cornelius, G Linette, R Fields British Journal of Dermatology, 2016 | 27 | 2016 |
| Neutrophil‐predominant bullous pemphigoid induced by checkpoint inhibitors: a case series LM Morris, HA Lewis, LA Cornelius, DY Chen, IS Rosman Journal of cutaneous pathology 47 (8), 742-746, 2020 | 18 | 2020 |
| DNMT3AR882-associated hypomethylation patterns are maintained in primary AML xenografts, but not in the DNMT3AR882C OCI-AML3 leukemia cell line D Chen, M Christopher, N Helton, I Ferguson, T Ley, D Spencer Blood Cancer Journal 8 (4), 2018 | 14 | 2018 |
| Successful administration of sequential TVEC and pembrolizumab followed by temozolomide in immunotherapy refractory intracranial metastatic melanoma with acquired B2M mutation K Khaddour, J Dowling, J Huang, M Council, D Chen, L Cornelius, ... Oncotarget 11 (52), 4836, 2020 | 10 | 2020 |
| Mutation detection in thousands of acute myeloid leukemia cells using single cell RNA-sequencing AA Petti, SR Williams, CA Miller, IT Fiddes, SN Srivatsan, DY Chen, ... BioRxiv, 434746, 2018 | 10 | 2018 |
| Malignant melanoma: evolving practice management in an era of increasingly effective systemic therapies K Newcomer, KJ Robbins, J Perone, FL Hinojosa, D Chen, S Jones, ... Current problems in surgery 59 (1), 101030, 2022 | 7 | 2022 |
| Dnmt3a deficiency in the skin causes focal, canonical DNA hypomethylation and a cellular proliferation phenotype DY Chen, IM Ferguson, KA Braun, LA Sutton, NM Helton, ... Proceedings of the National Academy of Sciences 118 (16), e2022760118, 2021 | 6 | 2021 |
| CD4 T cells and toxicity from immune checkpoint blockade N Earland, W Zhang, A Usmani, A Nene, A Bacchiocchi, DY Chen, ... Immunological Reviews 318 (1), 96-109, 2023 | 4 | 2023 |
| Combined Kdm6a and Trp53 deficiency drives the development of squamous cell skin cancer in mice LK Shea, NS Akhave, LA Sutton, LA Compton, C York, SM Ramakrishnan, ... Journal of Investigative Dermatology 143 (2), 232-241. e6, 2023 | 4 | 2023 |
TJ LeyProfessor of Medicine and Genetics, Washington University School of MedicineVerified email at wustl.edu
