Tjakko van Ham
Tjakko van Ham
Erasmus MC, Rotterdam, the Netherlands
Verified email at
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C. elegans model identifies genetic modifiers of α-synuclein inclusion formation during aging
TJ Van Ham, KL Thijssen, R Breitling, RMW Hofstra, RHA Plasterk, ...
PLoS genetics 4 (3), 2008
Identification of MOAG-4/SERF as a regulator of age-related proteotoxicity
TJ van Ham, MA Holmberg, AT van der Goot, E Teuling, ...
Cell 142 (4), 601-612, 2010
Live imaging of apoptotic cells in zebrafish
TJ van Ham, J Mapes, D Kokel, RT Peterson
The FASEB Journal 24 (11), 4336-4342, 2010
Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/α‐synuclein complex by Hip
C Roodveldt, CW Bertoncini, A Andersson, AT Van Der Goot, ST Hsu, ...
The EMBO journal 28 (23), 3758-3770, 2009
Neurodegenerative diseases: lessons from genome‐wide screens in small model organisms
TJ van Ham, R Breitling, MA Swertz, EAA Nollen
EMBO molecular medicine 1 (8‐9), 360-370, 2009
Identification of nonvisual photomotor response cells in the vertebrate hindbrain
D Kokel, TW Dunn, MB Ahrens, R Alshut, CYJ Cheung, L Saint-Amant, ...
Journal of Neuroscience 33 (9), 3834-3843, 2013
A FRET sensor for non‐invasive imaging of amyloid formation in vivo
GS Kaminski Schierle, CW Bertoncini, FTS Chan, AT van der Goot, ...
ChemPhysChem 12 (3), 673-680, 2011
Towards multiparametric fluorescent imaging of amyloid formation: studies of a YFP model of α-synuclein aggregation
TJ van Ham, A Esposito, JR Kumita, STD Hsu, GSK Schierle, CF Kaminski, ...
Journal of molecular biology 395 (3), 627-642, 2010
Apoptotic cells are cleared by directional migration and elmo1-dependent macrophage engulfment
TJ van Ham, D Kokel, RT Peterson
Current Biology 22 (9), 830-836, 2012
Intravital correlated microscopy reveals differential macrophage and microglial dynamics during resolution of neuroinflammation
TJ van Ham, CA Brady, RD Kalicharan, N Oosterhof, J Kuipers, ...
Disease models & mechanisms 7 (7), 857-869, 2014
Whole exome sequencing coupled with unbiased functional analysis reveals new Hirschsprung disease genes
H Gui, D Schriemer, WW Cheng, RK Chauhan, G Antiňolo, C Berrios, ...
Genome biology 18 (1), 48, 2017
Immune cell dynamics in the CNS: Learning from the zebrafish
N Oosterhof, E Boddeke, TJ van Ham
Glia 63 (5), 719-735, 2015
Homozygous mutations in CSF1R cause a pediatric-onset leukoencephalopathy and can result in congenital absence of microglia
N Oosterhof, IJ Chang, EG Karimiani, LE Kuil, DM Jensen, R Daza, ...
The American Journal of Human Genetics 104 (5), 936-947, 2019
Dynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages in zebrafish spinal cord regeneration
TM Tsarouchas, D Wehner, L Cavone, T Munir, M Keatinge, M Lambertus, ...
Nature communications 9 (1), 1-17, 2018
A small molecule that induces intrinsic pathway apoptosis with unparalleled speed
R Palchaudhuri, MJ Lambrecht, RC Botham, KC Partlow, TJ Van Ham, ...
Cell reports 13 (9), 2027-2036, 2015
Identification of a conserved and acute neurodegeneration‐specific microglial transcriptome in the zebrafish
N Oosterhof, IR Holtman, LE Kuil, HC van der Linde, EWGM Boddeke, ...
Glia 65 (1), 138-149, 2017
FLIPPER, a combinatorial probe for correlated live imaging and electron microscopy, allows identification and quantitative analysis of various cells and organelles
J Kuipers, TJ van Ham, RD Kalicharan, A Veenstra-Algra, KA Sjollema, ...
Cell and tissue research 360 (1), 61-70, 2015
Colony-stimulating factor 1 receptor (CSF1R) regulates microglia density and distribution, but not microglia differentiation in vivo
N Oosterhof, LE Kuil, HC van der Linde, SM Burm, W Berdowski, ...
Cell reports 24 (5), 1203-1217. e6, 2018
An in vivo zebrafish screen identifies organophosphate antidotes with diverse mechanisms of action
S Jin, KS Sarkar, YN Jin, Y Liu, D Kokel, TJ Van Ham, LD Roberts, ...
Journal of biomolecular screening 18 (1), 108-115, 2013
Large-scale scanning transmission electron microscopy (nanotomy) of healthy and injured zebrafish brain
J Kuipers, RD Kalicharan, AHG Wolters, TJ van Ham, BNG Giepmans
JoVE (Journal of Visualized Experiments), e53635, 2016
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