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Othon Iliopoulos
Othon Iliopoulos
Associate Professor of Medicine, Harvard Medical School
Verified email at mgh.harvard.edu
Title
Cited by
Cited by
Year
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
CM Metallo, PA Gameiro, EL Bell, KR Mattaini, J Yang, K Hiller, ...
Nature 481 (7381), 380-384, 2012
19032012
The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1α
L Zhong, A D'Urso, D Toiber, C Sebastian, RE Henry, DD Vadysirisack, ...
Cell 140 (2), 280-293, 2010
11162010
Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein.
O Iliopoulos, AP Levy, C Jiang, WG Kaelin Jr, MA Goldberg
Proceedings of the National Academy of Sciences 93 (20), 10595-10599, 1996
10571996
Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase
T Kamura, DM Koepp, MN Conrad, D Skowyra, RJ Moreland, O Iliopoulos, ...
Science 284 (5414), 657-661, 1999
9581999
Tumour suppression by the human von Hippel-Lindau gene product
O Iliopoulos, A Kibel, S Gray, WG Kaelin Jr
Nature medicine 1 (8), 822-826, 1995
8691995
Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C
A Kibel, O Iliopoulos, JA DeCaprio, WG Kaelin Jr
Science 269 (5229), 1444-1446, 1995
8461995
The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix
M Ohh, RL Yauch, KM Lonergan, JM Whaley, AO Stemmer-Rachamimov, ...
Molecular cell 1 (7), 959-968, 1998
5961998
Induction of interleukin-8 preserves the angiogenic response in HIF-1α–deficient colon cancer cells
Y Mizukami, WS Jo, EM Duerr, M Gala, J Li, X Zhang, MA Zimmer, ...
Nature medicine 11 (9), 992-997, 2005
5172005
Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2
KM Lonergan, O Iliopoulos, M Ohh, T Kamura, RC Conaway, ...
Molecular and cellular biology 18 (2), 732-741, 1998
5171998
Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL−/− tumors
M Zimmer, D Doucette, N Siddiqui, O Iliopoulos
Molecular Cancer Research 2 (2), 89-95, 2004
3492004
Belzutifan for renal cell carcinoma in von Hippel–Lindau disease
E Jonasch, F Donskov, O Iliopoulos, WK Rathmell, VK Narayan, ...
New England Journal of Medicine 385 (22), 2036-2046, 2021
3442021
In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation
PA Gameiro, J Yang, AM Metelo, R Pérez-Carro, R Baker, Z Wang, ...
Cell metabolism 17 (3), 372-385, 2013
3442013
pVHL19 is a biologically active product of the von Hippel–Lindau gene arising from internal translation initiation
O Iliopoulos, M Ohh, WG Kaelin Jr
Proceedings of the National Academy of Sciences 95 (20), 11661-11666, 1998
3291998
Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer
Y Mizukami, J Li, X Zhang, MA Zimmer, O Iliopoulos, DC Chung
Cancer research 64 (5), 1765-1772, 2004
2512004
Small-molecule inhibitors of HIF-2a translation link its 5′ UTR iron-responsive element to oxygen sensing
M Zimmer, BL Ebert, C Neil, K Brenner, I Papaioannou, A Melas, ...
Molecular cell 32 (6), 838-848, 2008
2282008
Hypoxia-induced mixed-lineage leukemia 1 regulates glioma stem cell tumorigenic potential
JM Heddleston, Q Wu, M Rivera, S Minhas, JD Lathia, AE Sloan, ...
Cell Death & Differentiation 19 (3), 428-439, 2012
1482012
Immunostaining of the von Hippel-Lindau gene product in normal and neoplastic human tissues
CL Corless, AS Kibel, O Iliopoulos, WG Kaelin Jr
Human pathology 28 (4), 459-464, 1997
1481997
Assessment of overall survival, quality of life, and safety benefits associated with new cancer medicines
S Salas-Vega, O Iliopoulos, E Mossialos
JAMA oncology 3 (3), 382-390, 2017
1422017
Cofactor Balance by Nicotinamide Nucleotide Transhydrogenase (NNT) Coordinates Reductive Carboxylation and Glucose Catabolism in the Tricarboxylic Acid (TCA) Cycle*♦
PA Gameiro, LA Laviolette, JK Kelleher, O Iliopoulos, G Stephanopoulos
Journal of Biological Chemistry 288 (18), 12967-12977, 2013
1312013
von Hippel-Lindau gene-mediated growth suppression and induction of differentiation in renal cell carcinoma cells grown as multicellular tumor spheroids
B Lieubeau-Teillet, J Rak, S Jothy, O Iliopoulos, W Kaelin, RS Kerbel
Cancer research 58 (21), 4957-4962, 1998
1261998
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