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John F Hancock
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All ras proteins are polyisoprenylated but only some are palmitoylated
JF Hancock, AI Magee, JE Childs, CJ Marshall
Cell 57 (7), 1167-1177, 1989
22881989
A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane
JF Hancock, H Paterson, CJ Marshall
Cell 63 (1), 133-139, 1990
14001990
Activation of Raf as a result of recruitment to the plasma membrane
SM Hancock JF, Stokoe D, Macdonald SG, Cadwallader K
Science 264, 1463-1467, 1994
12331994
Ras proteins: different signals from different locations
JF Hancock
Nature reviews Molecular cell biology 4 (5), 373-385, 2003
10712003
Lipid rafts: contentious only from simplistic standpoints
JF Hancock
Nature Reviews Molecular Cell Biology 7 (6), 456-462, 2006
9612006
Direct visualization of Ras proteins in spatially distinct cell surface microdomains
IA Prior, C Muncke, RG Parton, JF Hancock
Journal of Cell Biology 160 (2), 165-170, 2003
8682003
PTRF-Cavin, a conserved cytoplasmic protein required for caveola formation and function
MM Hill, M Bastiani, R Luetterforst, M Kirkham, A Kirkham, SJ Nixon, ...
Cell 132 (1), 113-124, 2008
7612008
Signalling ballet in space and time
BN Kholodenko, JF Hancock, W Kolch
Nature reviews Molecular cell biology 11 (6), 414-426, 2010
6742010
GTP-dependent segregation of H-ras from lipid rafts is required for biological activity
IA Prior, A Harding, J Yan, J Sluimer, RG Parton, JF Hancock
Nature cell biology 3 (4), 368-375, 2001
6582001
A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins
JF Hancock, K Cadwaller, H Paterson, CJ Marshall
The EMBO Journal 10 (13), 4033-4039, 1991
6481991
Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase
J Yan, S Roy, A Apolloni, A Lane, JF Hancock
Journal of Biological Chemistry 273 (37), 24052-24056, 1998
6201998
Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domains
S Roy, R Luetterforst, A Harding, A Apolloni, M Etheridge, E Stang, ...
Nature cell biology 1 (2), 98-105, 1999
6081999
Post‐translational processing of p21ras is two‐step and involves carboxyl‐methylation and carboxy‐terminal proteolysis.
L Gutierrez, AI Magee, CJ Marshall, JF Hancock
The EMBO journal 8 (4), 1093-1098, 1989
5841989
H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway
A Apolloni, IA Prior, M Lindsay, RG Parton, JF Hancock
Molecular and Cellular Biology 20 (7), 2475-2487, 2000
5552000
H-ras, K-ras, and inner plasma membrane raft proteins operate in nanoclusters with differential dependence on the actin cytoskeleton
SJ Plowman, C Muncke, RG Parton, JF Hancock
Proceedings of the National Academy of Sciences 102 (43), 15500-15505, 2005
5092005
Ultrastructural identification of uncoated caveolin-independent early endocytic vehicles
M Kirkham, A Fujita, R Chadda, SJ Nixon, TV Kurzchalia, DK Sharma, ...
The Journal of cell biology 168 (3), 465-476, 2005
5072005
The cytoplasmic protein GAP is implicated as the target for regulation by the ras gene product
C CalÚs, JF Hancock, CJ Marshall, A Hall
Nature 332 (6164), 548-551, 1988
4911988
Plasma membrane nanoswitches generate high-fidelity Ras signal transduction
T Tian, A Harding, K Inder, S Plowman, RG Parton, JF Hancock
Nature cell biology 9 (8), 905-914, 2007
4172007
Methylation and proteolysis are essential for efficient membrane binding of prenylated p21K‐ras (B).
JF Hancock, K Cadwallader, CJ Marshall
The EMBO journal 10 (3), 641-646, 1991
3941991
Lipid rafts and membrane traffic
MF Hanzal-Bayer, JF Hancock
FEBS letters 581 (11), 2098-2104, 2007
3782007
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