| Utility of B-factors in protein science: interpreting rigidity, flexibility, and internal motion and engineering thermostability Z Sun, Q Liu, G Qu, Y Feng, MT Reetz Chemical reviews 119 (3), 1626-1665, 2019 | 380 | 2019 |
| The crucial role of methodology development in directed evolution of selective enzymes G Qu, A Li, CG Acevedo‐Rocha, Z Sun, MT Reetz Angewandte Chemie International Edition 59 (32), 13204-13231, 2020 | 315 | 2020 |
| Catalytic asymmetric reduction of difficult-to-reduce ketones: triple-code saturation mutagenesis of an alcohol dehydrogenase Z Sun, R Lonsdale, A Ilie, G Li, J Zhou, MT Reetz ACS Catalysis 6 (3), 1598-1605, 2016 | 124 | 2016 |
| Structure-guided triple-code saturation mutagenesis: efficient tuning of the stereoselectivity of an epoxide hydrolase Z Sun, R Lonsdale, L Wu, G Li, A Li, J Wang, J Zhou, MT Reetz ACS Catalysis 6 (3), 1590-1597, 2016 | 115 | 2016 |
| Reshaping an Enzyme Binding Pocket for Enhanced and Inverted Stereoselectivity: Use of Smallest Amino Acid Alphabets in Directed Evolution Z Sun, R Lonsdale, XD Kong, JH Xu, J Zhou, MT Reetz Angewandte Chemie 54, 12410-12415, 2015 | 114 | 2015 |
| New concepts for increasing the efficiency in directed evolution of stereoselective enzymes Z Sun, Y Wikmark, JE Bäckvall, MT Reetz Chemistry–A European Journal 22 (15), 5046-5054, 2016 | 85 | 2016 |
| Whole‐cell‐catalyzed multiple regio‐and stereoselective functionalizations in cascade reactions enabled by directed evolution A Li, A Ilie, Z Sun, R Lonsdale, JH Xu, MT Reetz Angewandte Chemie 128 (39), 12205-12208, 2016 | 81 | 2016 |
| Metabolic engineering of the L-phenylalanine pathway in Escherichia coli for the production of S- or R-mandelic acid Z Sun, Y Ning, L Liu, Y Liu, B Sun, W Jiang, C Yang, S Yang Microbial cell factories 10, 1-13, 2011 | 71 | 2011 |
| Biocatalysis of carboxylic acid reductases: phylogenesis, catalytic mechanism and potential applications G Qu, J Guo, D Yang, Z Sun Green chemistry 20 (4), 777-792, 2018 | 69 | 2018 |
| Multiparameter optimization in directed evolution: engineering thermostability, enantioselectivity, and activity of an epoxide hydrolase G Li, H Zhang, Z Sun, X Liu, MT Reetz ACS Catalysis 6 (6), 3679-3687, 2016 | 67 | 2016 |
| Identification of Absidia orchidis steroid 11β-hydroxylation system and its application in engineering Saccharomyces cerevisiae for one-step biotransformation to produce … J Chen, F Fan, G Qu, J Tang, Y Xi, C Bi, Z Sun, X Zhang Metabolic engineering 57, 31-42, 2020 | 66 | 2020 |
| Conformational dynamics‐guided loop engineering of an alcohol dehydrogenase: capture, turnover and enantioselective transformation of difficult‐to‐reduce ketones B Liu, G Qu, JK Li, W Fan, JA Ma, Y Xu, Y Nie, Z Sun Advanced Synthesis & Catalysis 361 (13), 3182-3190, 2019 | 64 | 2019 |
| Identification of a novel cytochrome P450 enzyme that catalyzes the C-2α hydroxylation of pentacyclic triterpenoids and its application in yeast cell factories Z Dai, Y Liu, Z Sun, D Wang, G Qu, X Ma, F Fan, L Zhang, S Li, X Zhang Metabolic engineering 51, 70-78, 2019 | 64 | 2019 |
| Near-perfect control of the regioselective glucosylation enabled by rational design of glycosyltransferases J Li, G Qu, N Shang, P Chen, Y Men, W Liu, Z Mei, Y Sun, Z Sun Green Synthesis and Catalysis 2 (1), 45-53, 2021 | 59 | 2021 |
| Structural and computational insight into the catalytic mechanism of limonene epoxide hydrolase mutants in stereoselective transformations Z Sun, L Wu, M Bocola, HCS Chan, R Lonsdale, XD Kong, S Yuan, ... Journal of the American Chemical Society 140 (1), 310-318, 2018 | 47 | 2018 |
| Statistical analysis of the benefits of focused saturation mutagenesis in directed evolution based on reduced amino acid alphabets A Li, G Qu, Z Sun, MT Reetz Acs Catalysis 9 (9), 7769-7778, 2019 | 43 | 2019 |
| Beating Bias in the Directed Evolution of Proteins: Combining High‐Fidelity on‐Chip Solid‐Phase Gene Synthesis with Efficient Gene Assembly for Combinatorial Library Construction A Li, CG Acevedo‐Rocha, Z Sun, T Cox, JL Xu, MT Reetz ChemBioChem 19 (3), 221-228, 2018 | 41 | 2018 |
| Unlocking the stereoselectivity and substrate acceptance of enzymes: Proline‐induced loop engineering test G Qu, Y Bi, B Liu, J Li, X Han, W Liu, Y Jiang, Z Qin, Z Sun Angewandte Chemie International Edition 61 (1), e202110793, 2022 | 40 | 2022 |
| C–H bond functionalization reactions enabled by photobiocatalytic cascades Y Li, B Yuan, Z Sun, W Zhang Green Synthesis and Catalysis 2 (3), 267-274, 2021 | 39 | 2021 |
| Comparing different strategies in directed evolution of enzyme stereoselectivity: single‐versus double‐code saturation mutagenesis Z Sun, R Lonsdale, G Li, MT Reetz ChemBioChem 17 (19), 1865-1872, 2016 | 37 | 2016 |
Richard LonsdaleGlaxoSmithKlineVerified email at gsk.com
