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vinod kumar bhaskara pillai
vinod kumar bhaskara pillai
Senior Scientist, NGM Bio, South San Francisco
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Year
SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70
NR Sundaresan, SA Samant, VB Pillai, SB Rajamohan, MP Gupta
Molecular and cellular biology 28 (20), 6384-6401, 2008
6232008
The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun
NR Sundaresan, P Vasudevan, L Zhong, G Kim, S Samant, V Parekh, ...
Nature medicine 18 (11), 1643-1650, 2012
4662012
Exogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3-LKB1-AMP-activated kinase pathway
VB Pillai, NR Sundaresan, G Kim, M Gupta, SB Rajamohan, JB Pillai, ...
Journal of Biological Chemistry 285 (5), 3133-3144, 2010
4632010
SIRT3 deacetylates and activates OPA1 to regulate mitochondrial dynamics during stress
SA Samant, HJ Zhang, Z Hong, VB Pillai, NR Sundaresan, D Wolfgeher, ...
Molecular and cellular biology 34 (5), 807-819, 2014
3992014
Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3
VB Pillai, S Samant, NR Sundaresan, H Raghuraman, G Kim, MY Bonner, ...
Nature communications 6 (1), 6656, 2015
3842015
The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy
NR Sundaresan, VB Pillai, D Wolfgeher, S Samant, P Vasudevan, ...
Science signaling 4 (182), ra46-ra46, 2011
3472011
SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly (ADP-ribose) polymerase 1
SB Rajamohan, VB Pillai, M Gupta, NR Sundaresan, KG Birukov, ...
Molecular and cellular biology 29 (15), 4116-4129, 2009
3432009
Regulation of Akt signaling by sirtuins: its implication in cardiac hypertrophy and aging
VB Pillai, NR Sundaresan, MP Gupta
Circulation research 114 (2), 368-378, 2014
2682014
SIRT3 blocks aging-associated tissue fibrosis in mice by deacetylating and activating glycogen synthase kinase 3β
NR Sundaresan, S Bindu, VB Pillai, S Samant, Y Pan, JY Huang, M Gupta, ...
Molecular and cellular biology 36 (5), 678-692, 2016
1762016
Mitochondrial SIRT3 and heart disease
VB Pillai, NR Sundaresan, V Jeevanandam, MP Gupta
Cardiovascular research 88 (2), 250-256, 2010
1562010
Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice
VB Pillai, A Kanwal, YH Fang, WW Sharp, S Samant, J Arbiser, MP Gupta
Oncotarget 8 (21), 34082, 2017
1532017
Sirt3 protects mitochondrial DNA damage and blocks the development of doxorubicin-induced cardiomyopathy in mice
VB Pillai, S Bindu, W Sharp, YH Fang, G Kim, M Gupta, S Samant, ...
American Journal of Physiology-Heart and Circulatory Physiology 310 (8 …, 2016
1402016
Emerging roles of SIRT1 deacetylase in regulating cardiomyocyte survival and hypertrophy
NR Sundaresan, VB Pillai, MP Gupta
Journal of molecular and cellular cardiology 51 (4), 614-618, 2011
1302011
Nampt secreted from cardiomyocytes promotes development of cardiac hypertrophy and adverse ventricular remodeling
VB Pillai, NR Sundaresan, G Kim, S Samant, L Moreno-Vinasco, ...
American Journal of Physiology-Heart and Circulatory Physiology 304 (3 …, 2013
932013
Role of sirtuins in regulating pathophysiology of the heart
S Bindu, VB Pillai, MP Gupta
Trends in Endocrinology & Metabolism 27 (8), 563-573, 2016
792016
SIRT3 blocks myofibroblast differentiation and pulmonary fibrosis by preventing mitochondrial DNA damage
S Bindu, VB Pillai, A Kanwal, S Samant, GM Mutlu, E Verdin, N Dulin, ...
American Journal of Physiology-Lung Cellular and Molecular Physiology 312 (1 …, 2017
772017
The nuclear and mitochondrial sirtuins, Sirt6 and Sirt3, regulate each other’s activity and protect the heart from developing obesity-mediated diabetic cardiomyopathy
A Kanwal, VB Pillai, S Samant, M Gupta, MP Gupta
The FASEB Journal 33 (10), 10872, 2019
742019
Germline BRCA1 mutation analysis in Indian breast/ovarian cancer families.
SK Kumar BV, Lakhotia S, Ankathil R, Madhavan J, Jayaprakash PG, Nair MK
Cancer Biol Ther 1 (1), 18-21, 2002
632002
CD40L-adjuvanted DNA/modified vaccinia virus Ankara simian immunodeficiency virus SIV239 vaccine enhances SIV-specific humoral and cellular immunity and improves protection …
S Kwa, L Lai, S Gangadhara, M Siddiqui, VB Pillai, C Labranche, T Yu, ...
Journal of virology 88 (17), 9579-9589, 2014
612014
Acetylation of a conserved lysine residue in the ATP binding pocket of p38 augments its kinase activity during hypertrophy of cardiomyocytes
VB Pillai, NR Sundaresan, SA Samant, D Wolfgeher, CM Trivedi, ...
Molecular and cellular biology 31 (11), 2349-2363, 2011
612011
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