SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70 NR Sundaresan, SA Samant, VB Pillai, SB Rajamohan, MP Gupta Molecular and cellular biology 28 (20), 6384-6401, 2008 | 623 | 2008 |
The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun NR Sundaresan, P Vasudevan, L Zhong, G Kim, S Samant, V Parekh, ... Nature medicine 18 (11), 1643-1650, 2012 | 466 | 2012 |
Exogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3-LKB1-AMP-activated kinase pathway VB Pillai, NR Sundaresan, G Kim, M Gupta, SB Rajamohan, JB Pillai, ... Journal of Biological Chemistry 285 (5), 3133-3144, 2010 | 463 | 2010 |
SIRT3 deacetylates and activates OPA1 to regulate mitochondrial dynamics during stress SA Samant, HJ Zhang, Z Hong, VB Pillai, NR Sundaresan, D Wolfgeher, ... Molecular and cellular biology 34 (5), 807-819, 2014 | 399 | 2014 |
Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3 VB Pillai, S Samant, NR Sundaresan, H Raghuraman, G Kim, MY Bonner, ... Nature communications 6 (1), 6656, 2015 | 384 | 2015 |
The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy NR Sundaresan, VB Pillai, D Wolfgeher, S Samant, P Vasudevan, ... Science signaling 4 (182), ra46-ra46, 2011 | 347 | 2011 |
SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly (ADP-ribose) polymerase 1 SB Rajamohan, VB Pillai, M Gupta, NR Sundaresan, KG Birukov, ... Molecular and cellular biology 29 (15), 4116-4129, 2009 | 343 | 2009 |
Regulation of Akt signaling by sirtuins: its implication in cardiac hypertrophy and aging VB Pillai, NR Sundaresan, MP Gupta Circulation research 114 (2), 368-378, 2014 | 268 | 2014 |
SIRT3 blocks aging-associated tissue fibrosis in mice by deacetylating and activating glycogen synthase kinase 3β NR Sundaresan, S Bindu, VB Pillai, S Samant, Y Pan, JY Huang, M Gupta, ... Molecular and cellular biology 36 (5), 678-692, 2016 | 176 | 2016 |
Mitochondrial SIRT3 and heart disease VB Pillai, NR Sundaresan, V Jeevanandam, MP Gupta Cardiovascular research 88 (2), 250-256, 2010 | 156 | 2010 |
Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice VB Pillai, A Kanwal, YH Fang, WW Sharp, S Samant, J Arbiser, MP Gupta Oncotarget 8 (21), 34082, 2017 | 153 | 2017 |
Sirt3 protects mitochondrial DNA damage and blocks the development of doxorubicin-induced cardiomyopathy in mice VB Pillai, S Bindu, W Sharp, YH Fang, G Kim, M Gupta, S Samant, ... American Journal of Physiology-Heart and Circulatory Physiology 310 (8 …, 2016 | 140 | 2016 |
Emerging roles of SIRT1 deacetylase in regulating cardiomyocyte survival and hypertrophy NR Sundaresan, VB Pillai, MP Gupta Journal of molecular and cellular cardiology 51 (4), 614-618, 2011 | 130 | 2011 |
Nampt secreted from cardiomyocytes promotes development of cardiac hypertrophy and adverse ventricular remodeling VB Pillai, NR Sundaresan, G Kim, S Samant, L Moreno-Vinasco, ... American Journal of Physiology-Heart and Circulatory Physiology 304 (3 …, 2013 | 93 | 2013 |
Role of sirtuins in regulating pathophysiology of the heart S Bindu, VB Pillai, MP Gupta Trends in Endocrinology & Metabolism 27 (8), 563-573, 2016 | 79 | 2016 |
SIRT3 blocks myofibroblast differentiation and pulmonary fibrosis by preventing mitochondrial DNA damage S Bindu, VB Pillai, A Kanwal, S Samant, GM Mutlu, E Verdin, N Dulin, ... American Journal of Physiology-Lung Cellular and Molecular Physiology 312 (1 …, 2017 | 77 | 2017 |
The nuclear and mitochondrial sirtuins, Sirt6 and Sirt3, regulate each other’s activity and protect the heart from developing obesity-mediated diabetic cardiomyopathy A Kanwal, VB Pillai, S Samant, M Gupta, MP Gupta The FASEB Journal 33 (10), 10872, 2019 | 74 | 2019 |
Germline BRCA1 mutation analysis in Indian breast/ovarian cancer families. SK Kumar BV, Lakhotia S, Ankathil R, Madhavan J, Jayaprakash PG, Nair MK Cancer Biol Ther 1 (1), 18-21, 2002 | 63 | 2002 |
CD40L-adjuvanted DNA/modified vaccinia virus Ankara simian immunodeficiency virus SIV239 vaccine enhances SIV-specific humoral and cellular immunity and improves protection … S Kwa, L Lai, S Gangadhara, M Siddiqui, VB Pillai, C Labranche, T Yu, ... Journal of virology 88 (17), 9579-9589, 2014 | 61 | 2014 |
Acetylation of a conserved lysine residue in the ATP binding pocket of p38 augments its kinase activity during hypertrophy of cardiomyocytes VB Pillai, NR Sundaresan, SA Samant, D Wolfgeher, CM Trivedi, ... Molecular and cellular biology 31 (11), 2349-2363, 2011 | 61 | 2011 |