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Prema Iyer
Prema Iyer
Assistant Professor of Department of Pharmaceutical Sciences, University of Pittsburgh
Verified email at pitt.edu - Homepage
Title
Cited by
Cited by
Year
Characterization of the interactions of potent allosteric inhibitors with glutaminase C, a key enzyme in cancer cell glutamine metabolism
Q Huang, C Stalnecker, C Zhang, LA McDermott, P Iyer, J O’Neill, ...
Journal of Biological Chemistry 293 (10), 3535-3545, 2018
922018
Design and evaluation of novel glutaminase inhibitors
LA McDermott, P Iyer, L Vernetti, S Rimer, J Sun, M Boby, T Yang, ...
Bioorganic & medicinal chemistry 24 (8), 1819-1839, 2016
672016
Design and activity of AP endonuclease-1 inhibitors
Z Feng, S Kochanek, D Close, LR Wang, A Srinivasan, AA Almehizia, ...
Journal of chemical biology 8, 79-93, 2015
322015
Mutagenicity of N3-methyladenine: a multi-translesion polymerase affair
P Monti, I Traverso, L Casolari, P Menichini, A Inga, L Ottaggio, D Russo, ...
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 683 (1 …, 2010
232010
Synthesis and structure–activity analysis of diphenylpyrazolodiazene inhibitors of the HIV-1 Nef virulence factor
PC Iyer, J Zhao, LA Emert-Sedlak, KK Moore, TE Smithgall, BW Day
Bioorganic & medicinal chemistry letters 24 (7), 1702-1706, 2014
202014
Connecting neuronal cell protective pathways and drug combinations in a Huntington’s disease model through the application of quantitative systems pharmacology
F Pei, H Li, MJ Henderson, SA Titus, A Jadhav, A Simeonov, ...
Scientific Reports 7 (1), 17803, 2017
192017
An expeditious synthesis of a β-silylethanol anchoring group by a silicon directed Baeyer–Villiger oxidation on solid-phase
P Iyer, SK Ghosh
Tetrahedron letters 43 (51), 9437-9440, 2002
182002
Synthesis and characterization of DNA minor groove binding alkylating agents
P Iyer, A Srinivasan, SK Singh, GP Mascara, S Zayitova, B Sidone, ...
Chemical research in toxicology 26 (1), 156-168, 2013
162013
A Rapid and Efficient Synthesis of a Bifunctional β‐Silylketone, Precursor for a Solid Supported β‐Silylethanol Anchoring Group
SM Date, P Iyer, SK Ghosh
Synthetic communications 34 (3), 405-411, 2004
122004
GAC inhibitors with a 4-hydroxypiperidine spacer: Requirements for potency
L McDermott, D Koes, S Mohammed, P Iyer, M Boby, V Balasubramanian, ...
Bioorganic & medicinal chemistry letters 29 (19), 126632, 2019
112019
Current landscape of coccidioidomycosis
R Boro, PC Iyer, MA Walczak
Journal of Fungi 8 (4), 413, 2022
102022
High frequency of genomic deletions induced by Me-lex, a sequence selective N3-adenine methylating agent, at the Hprt locus in Chinese hamster ovary cells
D Russo, G Fronza, L Ottaggio, P Monti, A Inga, P Iyer, B Gold, ...
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 671 (1 …, 2009
72009
3‘-H-Phosphonate Synthesis of Chiral Benzo[a]pyrene Diol Epoxide Adducts at N2 of Deoxyguanosine in Oligonucleotides
PC Iyer, H Yagi, JM Sayer, DM Jerina
Chemical research in toxicology 20 (2), 311-315, 2007
52007
XRCC1 deficiency influences the cytotoxicity and the genomic instability induced by Me-lex, a specific inducer of N3-methyladenine
D Russo, G Fronza, L Ottaggio, P Monti, C Perfumo, A Inga, P Iyer, B Gold, ...
DNA repair 9 (7), 728-736, 2010
22010
Compounds for treating hiv and methods for using the compounds
TE Smithgall, LA Emert-Sedlak, BW Day, J Zhao, PC Iyer
US Patent 9,695,127, 2017
12017
Hdac inhibitors
P Wipf, DM Huryn, MG Laporte, L Terrab, MJ Houghton, A Topacio, ...
US Patent App. 18/039,941, 2024
2024
Glutaminase inhibitors
LA McDermott, PC Iyer, RA Cerione, WP Katt
US Patent 11,013,724, 2021
2021
Glutaminase inhibitors
LA McDermott, PC Iyer, RA Cerione, WP Katt
US Patent 10,245,254, 2019
2019
Synthesis and Biological Characterization of Minor Groove Binding Methylating Agents
P Iyer, S Singh, A Srinivasan, B Gold, G Mascara
CHEMICAL RESEARCH IN TOXICOLOGY 23 (1), 284-284, 2010
2010
TOXI 86-Synthesis and biological characterization of minor groove binding methylating agents
P Iyer, S Singh, A Srinivasan, B Gold, G Mascara
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 238, 2009
2009
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