Albert Li
Albert Li
In Vitro ADMET Laboratories LLC
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Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism …
NJ Hewitt, MJ Gómez Lechón, JB Houston, D Hallifax, HS Brown, ...
Drug metabolism reviews 39 (1), 159-234, 2007
Screening for human ADME/Tox drug properties in drug discovery
Drug discovery today 6 (7), 357-366, 2001
A simplified method for production and growth of multicellular tumor spheroids
JM Yuhas, AP Li, AO Martinez, AJ Ladman
Cancer research 37 (10), 3639-3643, 1977
Substrates of human hepatic cytochrome P450 3A4
AP Li, DL Kaminski, A Rasmussen
Toxicology 104 (1-3), 1-8, 1995
Inhibition of transporter-mediated hepatic uptake as a mechanism for drug-drug interaction between cerivastatin and cyclosporin A
Y Shitara, T Itoh, H Sato, AP Li, Y Sugiyama
Journal of Pharmacology and Experimental Therapeutics 304 (2), 610-616, 2003
Cryopreserved human hepatocytes: characterization of drug-metabolizing activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability …
AP Li, C Lu, JA Brent, C Pham, A Fackett, CE Ruegg, PM Silber
Chemico-biological interactions 121 (1), 17-35, 1999
Tissue factor: an enzyme cofactor and a true receptor
JH Morrissey
Thrombosis and haemostasis 86 (07), 66-74, 2001
Species comparison in P450 induction: effects of dexamethasone, omeprazole, and rifampin on P450 isoforms 1A and 3A in primary cultured hepatocytes from man, Sprague–Dawley rat …
C Lu, AP Li
Chemico-biological interactions 134 (3), 271-281, 2001
Human hepatocytes: isolation, cryopreservation and applications in drug development
Chemico-biological interactions 168 (1), 16-29, 2007
Effects of organic solvents on the activities of cytochrome P450 isoforms, UDP-dependent glucuronyl transferase, and phenol sulfotransferase in human hepatocytes
J Easterbrook, C Lu, Y Sakai, AP Li
Drug Metabolism and Disposition 29 (2), 141-144, 2001
Primary human hepatocytes as a tool for the evaluation of structure—activity relationship in cytochrome P450 induction potential of xenobiotics: evaluation of rifampin …
AP Li, MK Reith, A Rasmussen, JC Gorski, SD Hall, L Xu, DL Kaminski, ...
Chemico-biological interactions 107 (1-2), 17-30, 1997
A review of the common properties of drugs with idiosyncratic hepatotoxicity and the “multiple determinant hypothesis” for the manifestation of idiosyncratic drug toxicity
Chemico-biological interactions 142 (1-2), 7-23, 2002
Optimization of cryopreservation procedures for rat and human hepatocytes
LJ Loretz, AP Li, MW Flye, AGE Wilson
Xenobiotica 19 (5), 489-498, 1989
Present status of the application of cryopreserved hepatocytes in the evaluation of xenobiotics: consensus of an international expert panel
AP Li, PD Gorycki, JG Hengstler, GL Kedderis, HG Koebe, R Rahmani, ...
Chemico-biological interactions 121 (1), 117-123, 1999
Preclinical evaluation of drug—drug interaction potential: present status of the application of primary human hepatocytes in the evaluation of cytochrome P450 induction
AP Li, P Maurel, MJ Gomez-Lechon, LC Cheng, M Jurima-Romet
Chemico-biological interactions 107 (1-2), 5-16, 1997
A novel in vitro system, the integrated discrete multiple organ cell culture (IdMOC) system, for the evaluation of human drug toxicity: comparative cytotoxicity of tamoxifen …
AP Li, C Bode, Y Sakai
Chemico-biological interactions 150 (1), 129-136, 2004
Function of uptake transporters for taurocholate and estradiol 17β-d-glucuronide in cryopreserved human hepatocytes
Y Shitara, AP Li, Y Kato, C Lu, K Ito, T Itoh, Y Sugiyama
Drug metabolism and pharmacokinetics 18 (1), 33-41, 2003
Severe acute respiratory syndrome (SARS) in neonates and children
AM Li, PC Ng
Archives of Disease in Childhood-Fetal and Neonatal Edition 90 (6), F461-F465, 2005
Isolation and culturing of hepatocytes from human livers
AP Li, MA Roque, DJ Beck, DL Kaminski
Journal of tissue culture methods 14, 139-145, 1992
Applications of microarrays with toxicologically relevant genes (tox genes) for the evaluation of chemical toxicants in Sprague Dawley rats in vivo and human hepatocytes in vitro
LD Kier, R Neft, L Tang, R Suizu, T Cook, K Onsurez, K Tiegler, Y Sakai, ...
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 549 (1 …, 2004
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