| Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis EG Meyron‐Holtz, MC Ghosh, K Iwai, T LaVaute, X Brazzolotto, ... The EMBO journal 23 (2), 386-395, 2004 | 468 | 2004 |
| Comparison of the binding of reversible inhibitors to human butyrylcholinesterase and acetylcholinesterase: A crystallographic, kinetic and calorimetric study TL Rosenberry, X Brazzolotto, IR Macdonald, M Wandhammer, ... Molecules 22 (12), 2098, 2017 | 220 | 2017 |
| Biochemical characterization of the HydE and HydG iron-only hydrogenase maturation enzymes from Thermatoga maritima JK Rubach, X Brazzolotto, J Gaillard, M Fontecave FEBS letters 579 (22), 5055-5060, 2005 | 205 | 2005 |
| Progress in the development of enzyme-based nerve agent bioscavengers F Nachon, X Brazzolotto, M Trovaslet, P Masson Chemico-biological interactions 206 (3), 536-544, 2013 | 188 | 2013 |
| The [Fe-Fe]-hydrogenase maturation protein HydF from Thermotoga maritima is a GTPase with an iron-sulfur cluster X Brazzolotto, JK Rubach, J Gaillard, S Gambarelli, M Atta, M Fontecave Journal of Biological Chemistry 281 (2), 769-774, 2006 | 178 | 2006 |
| Discovery and structure–activity relationships of a highly selective butyrylcholinesterase inhibitor by structure-based virtual screening SN Dighe, GS Deora, E De la Mora, F Nachon, S Chan, MO Parat, ... Journal of medicinal chemistry 59 (16), 7683-7689, 2016 | 150 | 2016 |
| Human cytoplasmic aconitase (Iron regulatory protein 1) is converted into its [3Fe-4S] form by hydrogen peroxide in vitro but is not activated for iron-responsive element binding X Brazzolotto, J Gaillard, K Pantopoulos, MW Hentze, JM Moulis Journal of Biological Chemistry 274 (31), 21625-21630, 1999 | 144 | 1999 |
| The magic of crystal structure-based inhibitor optimization: development of a butyrylcholinesterase inhibitor with picomolar affinity and in vivo activity U Kosak, B Brus, D Knez, S Zakelj, J Trontelj, A Pislar, R Sink, M Jukic, ... Journal of medicinal chemistry 61 (1), 119-139, 2018 | 137 | 2018 |
| Development of an in-vivo active reversible butyrylcholinesterase inhibitor U Košak, B Brus, D Knez, R Šink, S Žakelj, J Trontelj, A Pišlar, J Šlenc, ... Scientific reports 6 (1), 39495, 2016 | 134 | 2016 |
| Human butyrylcholinesterase produced in insect cells: huprine‐based affinity purification and crystal structure X Brazzolotto, M Wandhammer, C Ronco, M Trovaslet, L Jean, ... The FEBS journal 279 (16), 2905-2916, 2012 | 112 | 2012 |
| Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease K Chalupova, J Korabecny, M Bartolini, B Monti, D Lamba, R Caliandro, ... European journal of medicinal chemistry 168, 491-514, 2019 | 92 | 2019 |
| Multi-target-directed ligands for treating Alzheimer's disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities D Knez, N Coquelle, A Pišlar, S Žakelj, M Jukič, M Sova, J Mravljak, ... European journal of medicinal chemistry 156, 598-617, 2018 | 83 | 2018 |
| Tryptophan-derived butyrylcholinesterase inhibitors as promising leads against Alzheimer's disease A Meden, D Knez, M Jukič, X Brazzolotto, M Gršič, A Pišlar, A Zahirović, ... Chemical communications 55 (26), 3765-3768, 2019 | 76 | 2019 |
| Organophosphate hydrolases as catalytic bioscavengers of organophosphorus nerve agents M Trovaslet-Leroy, L Musilova, F Renault, X Brazzolotto, J Misik, ... Toxicology letters 206 (1), 14-23, 2011 | 70 | 2011 |
| Peroxynitrite and Nitric Oxide Differently Target the Iron− Sulfur Cluster and Amino Acid Residues of Human Iron Regulatory Protein 1 E Soum, X Brazzolotto, C Goussias, C Bouton, JM Moulis, TA Mattioli, ... Biochemistry 42 (25), 7648-7654, 2003 | 66 | 2003 |
| N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer’s agents U Košak, D Knez, N Coquelle, B Brus, A Pišlar, F Nachon, X Brazzolotto, ... Bioorganic & medicinal chemistry 25 (2), 633-645, 2017 | 65 | 2017 |
| Structure-based development of nitroxoline derivatives as potential multifunctional anti-Alzheimer agents D Knez, B Brus, N Coquelle, I Sosič, R Šink, X Brazzolotto, J Mravljak, ... Bioorganic & Medicinal Chemistry 23 (15), 4442-4452, 2015 | 61 | 2015 |
| Discovery of a potent dual inhibitor of acetylcholinesterase and butyrylcholinesterase with antioxidant activity that alleviates Alzheimer-like pathology in old APP/PS1 mice E Viayna, N Coquelle, M Cieslikiewicz-Bouet, P Cisternas, CA Oliva, ... Journal of Medicinal Chemistry 64 (1), 812-839, 2020 | 51 | 2020 |
| N-alkylpiperidine carbamates as potential anti-Alzheimer’s agents U Košak, N Strašek, D Knez, M Jukič, S Žakelj, A Zahirović, A Pišlar, ... European Journal of Medicinal Chemistry 197, 112282, 2020 | 43 | 2020 |
| Interactions between doxorubicin and the human iron regulatory system X Brazzolotto, M Andriollo, P Guiraud, A Favier, JM Moulis Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1593 (2-3), 209-218, 2003 | 41 | 2003 |
