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Aparna Vasanthakumar
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Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
ME Figueroa, O Abdel-Wahab, C Lu, PS Ward, J Patel, A Shih, Y Li, ...
Cancer cell 18 (6), 553-567, 2010
30372010
Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation
K Moran-Crusio, L Reavie, A Shih, O Abdel-Wahab, D Ndiaye-Lobry, ...
Cancer cell 20 (1), 11-24, 2011
14332011
Dnmt3a is essential for hematopoietic stem cell differentiation
GA Challen, D Sun, M Jeong, M Luo, J Jelinek, JS Berg, C Bock, ...
Nature genetics 44 (1), 23-31, 2012
12492012
5-hmC–mediated epigenetic dynamics during postnatal neurodevelopment and aging
KE Szulwach, X Li, Y Li, CX Song, H Wu, Q Dai, H Irier, AK Upadhyay, ...
Nature neuroscience 14 (12), 1607-1616, 2011
8732011
Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis
L Busque, JP Patel, ME Figueroa, A Vasanthakumar, S Provost, ...
Nature genetics 44 (11), 1179-1181, 2012
8682012
DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia
R Rampal, A Alkalin, J Madzo, A Vasanthakumar, E Pronier, J Patel, Y Li, ...
Cell reports 9 (5), 1841-1855, 2014
3022014
Mechanism-based epigenetic chemosensitization therapy of diffuse large B-cell lymphoma
T Clozel, SN Yang, RL Elstrom, W Tam, P Martin, M Kormaksson, ...
Cancer discovery 3 (9), 1002-1019, 2013
2172013
Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors
E Pronier, C Almire, H Mokrani, A Vasanthakumar, A Simon, ...
Blood, The Journal of the American Society of Hematology 118 (9), 2551-2555, 2011
2102011
TET1-mediated hydroxymethylation facilitates hypoxic gene induction in neuroblastoma
CJ Mariani, A Vasanthakumar, J Madzo, A Yesilkanal, T Bhagat, Y Yu, ...
Cell reports 7 (5), 1343-1352, 2014
1782014
DNA methyltransferase 1 and DNA methylation patterning contribute to germinal center B-cell differentiation
R Shaknovich, L Cerchietti, L Tsikitas, M Kormaksson, S De, ME Figueroa, ...
Blood, The Journal of the American Society of Hematology 118 (13), 3559-3569, 2011
1512011
Effects of TET2 mutations on DNA methylation in chronic myelomonocytic leukemia
J Yamazaki, R Taby, A Vasanthakumar, T Macrae, KR Ostler, L Shen, ...
Epigenetics 7 (2), 201-207, 2012
1342012
Hydroxymethylation at gene regulatory regions directs stem/early progenitor cell commitment during erythropoiesis
J Madzo, H Liu, A Rodriguez, A Vasanthakumar, S Sundaravel, ...
Cell reports 6 (1), 231-244, 2014
1132014
Iron‐responsive degradation of iron‐regulatory protein 1 does not require the Fe–S cluster
SL Clarke, A Vasanthakumar, SA Anderson, C Pondarré, CM Koh, ...
The EMBO journal 25 (3), 544-553, 2006
1132006
TET2 mutations affect non-CpG island DNA methylation at enhancers and transcription factor–binding sites in chronic myelomonocytic leukemia
J Yamazaki, J Jelinek, Y Lu, M Cesaroni, J Madzo, F Neumann, R He, ...
Cancer research 75 (14), 2833-2843, 2015
1102015
5-hydroxymethylcytosine in cancer: significance in diagnosis and therapy
A Vasanthakumar, LA Godley
Cancer genetics 208 (5), 167-177, 2015
1082015
DNA methylation dynamics of germinal center B cells are mediated by AID
PM Dominguez, M Teater, N Chambwe, M Kormaksson, D Redmond, ...
Cell reports 12 (12), 2086-2098, 2015
1062015
Genome-wide hydroxymethylation tested using the HELP-GT assay shows redistribution in cancer
S Bhattacharyya, Y Yu, M Suzuki, N Campbell, J Mazdo, ...
Nucleic acids research 41 (16), e157-e157, 2013
812013
DNMT3B7, a truncated DNMT3B isoform expressed in human tumors, disrupts embryonic development and accelerates lymphomagenesis
MY Shah, A Vasanthakumar, NY Barnes, ME Figueroa, A Kamp, ...
Cancer research 70 (14), 5840-5850, 2010
682010
Harnessing peripheral DNA methylation differences in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) to reveal novel biomarkers of disease
A Vasanthakumar, JW Davis, K Idler, JF Waring, E Asque, B Riley-Gillis, ...
Clinical epigenetics 12, 1-11, 2020
522020
Dnmt3b is a haploinsufficient tumor suppressor gene in Myc-induced lymphomagenesis
A Vasanthakumar, JB Lepore, MH Zegarek, M Kocherginsky, M Singh, ...
Blood, The Journal of the American Society of Hematology 121 (11), 2059-2063, 2013
492013
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