Greg Delgoffe
Greg Delgoffe
Associate Professor of Immunology, University of Pittsburgh
Verified email at - Homepage
Cited by
Cited by
The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment
GM Delgoffe, TP Kole, Y Zheng, PE Zarek, KL Matthews, B Xiao, ...
Immunity 30 (6), 832-844, 2009
The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2
GM Delgoffe, KN Pollizzi, AT Waickman, E Heikamp, DJ Meyers, ...
Nature immunology 12 (4), 295-303, 2011
The tumor microenvironment represses T cell mitochondrial biogenesis to drive intratumoral T cell metabolic insufficiency and dysfunction
NE Scharping, AV Menk, RS Moreci, RD Whetstone, RE Dadey, ...
Immunity 45 (2), 374-388, 2016
Bioenergetic insufficiencies due to metabolic alterations regulated by the inhibitory receptor PD-1 are an early driver of CD8+ T cell exhaustion
B Bengsch, AL Johnson, M Kurachi, PM Odorizzi, KE Pauken, J Attanasio, ...
immunity 45 (2), 358-373, 2016
Stability and function of regulatory T cells is maintained by a neuropilin-1–semaphorin-4a axis
GM Delgoffe, SR Woo, ME Turnis, DM Gravano, C Guy, AE Overacre, ...
Nature 501 (7466), 252-256, 2013
The mammalian target of rapamycin: linking T cell differentiation, function, and metabolism
JD Powell, GM Delgoffe
Immunity 33 (3), 301-311, 2010
Metabolic support of tumour-infiltrating regulatory T cells by lactic acid
MLJ Watson, PDA Vignali, SJ Mullett, AE Overacre-Delgoffe, RM Peralta, ...
Nature 591 (7851), 645-651, 2021
The composition and signaling of the IL-35 receptor are unconventional
LW Collison, GM Delgoffe, CS Guy, KM Vignali, V Chaturvedi, ...
Nature immunology 13 (3), 290-299, 2012
Interferon-γ drives Treg fragility to promote anti-tumor immunity
AE Overacre-Delgoffe, M Chikina, RE Dadey, H Yano, EA Brunazzi, ...
Cell 169 (6), 1130-1141. e11, 2017
Efficacy of PD-1 blockade is potentiated by metformin-induced reduction of tumor hypoxia
NE Scharping, AV Menk, RD Whetstone, X Zeng, GM Delgoffe
Cancer immunology research 5 (1), 9-16, 2017
mTORC1 and mTORC2 selectively regulate CD8+ T cell differentiation
KN Pollizzi, CH Patel, IH Sun, MH Oh, AT Waickman, J Wen, GM Delgoffe, ...
The Journal of clinical investigation 125 (5), 2090-2108, 2015
Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion
NE Scharping, DB Rivadeneira, AV Menk, PDA Vignali, BR Ford, ...
Nature immunology 22 (2), 205-215, 2021
Early TCR signaling induces rapid aerobic glycolysis enabling distinct acute T cell effector functions
AV Menk, NE Scharping, RS Moreci, X Zeng, C Guy, S Salvatore, H Bae, ...
Cell reports 22 (6), 1509-1521, 2018
Anergic T cells are metabolically anergic
Y Zheng, GM Delgoffe, CF Meyer, W Chan, JD Powell
The Journal of Immunology 183 (10), 6095-6101, 2009
Interleukin-35 limits anti-tumor immunity
ME Turnis, DV Sawant, AL Szymczak-Workman, LP Andrews, ...
Immunity 44 (2), 316-329, 2016
Metabolic barriers to cancer immunotherapy
K DePeaux, GM Delgoffe
Nature Reviews Immunology 21 (12), 785-797, 2021
Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8+ T cell differentiation
KN Pollizzi, IH Sun, CH Patel, YC Lo, MH Oh, AT Waickman, AJ Tam, ...
Nature immunology 17 (6), 704-711, 2016
The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation
MF Gulen, Z Kang, K Bulek, W Youzhong, TW Kim, Y Chen, CZ Altuntas, ...
Immunity 32 (1), 54-66, 2010
4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses
AV Menk, NE Scharping, DB Rivadeneira, MJ Calderon, MLJ Watson, ...
Journal of experimental medicine 215 (4), 1091-1100, 2018
Treg cells promote the SREBP1-dependent metabolic fitness of tumor-promoting macrophages via repression of CD8+ T cell-derived interferon-γ
C Liu, M Chikina, R Deshpande, AV Menk, T Wang, T Tabib, EA Brunazzi, ...
Immunity 51 (2), 381-397. e6, 2019
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