| The crystal structure of a quercetin 2, 3-dioxygenase from Bacillus subtilis suggests modulation of enzyme activity by a change in the metal ion at the active site (s) B Gopal, LL Madan, SF Betz, AA Kossiakoff Biochemistry 44 (1), 193-201, 2005 | 172 | 2005 |
| Kinases and pseudokinases: lessons from RAF AS Shaw, AP Kornev, J Hu, LG Ahuja, SS Taylor Molecular and cellular biology 34 (9), 1538-1546, 2014 | 132 | 2014 |
| Kinase regulation by hydrophobic spine assembly in cancer J Hu, LG Ahuja, HS Meharena, N Kannan, AP Kornev, SS Taylor, ... Molecular and cellular biology 35 (1), 264-276, 2015 | 81 | 2015 |
| A dynamic hydrophobic core orchestrates allostery in protein kinases J Kim, LG Ahuja, FA Chao, Y Xia, CL McClendon, AP Kornev, SS Taylor, ... Science advances 3 (4), e1600663, 2017 | 75 | 2017 |
| Divalent Metal Ions Mg2+ and Ca2+ Have Distinct Effects on Protein Kinase A Activity and Regulation MJ Knape, LG Ahuja, D Bertinetti, NCG Burghardt, B Zimmermann, ... ACS chemical biology 10 (10), 2303-2315, 2015 | 56 | 2015 |
| Mutation of a kinase allosteric node uncouples dynamics linked to phosphotransfer LG Ahuja, AP Kornev, CL McClendon, G Veglia, SS Taylor Proceedings of the National Academy of Sciences 114 (6), E931-E940, 2017 | 39 | 2017 |
| Refolding and simultaneous purification by three‐phase partitioning of recombinant proteins from inclusion bodies S Raghava, B Barua, PK Singh, M Das, L Madan, S Bhattacharyya, ... Protein Science 17 (11), 1987-1997, 2008 | 33 | 2008 |
| Single turnover autophosphorylation cycle of the PKA RIIβ holoenzyme P Zhang, MJ Knape, LG Ahuja, MM Keshwani, CC King, M Sastri, ... PLoS biology 13 (7), e1002192, 2015 | 30 | 2015 |
| Tuning the “violin” of protein kinases: The role of dynamics‐based allostery LG Ahuja, SS Taylor, AP Kornev IUBMB life 71 (6), 685-696, 2019 | 27 | 2019 |
| Dynamic allostery-based molecular workings of kinase: peptide complexes LG Ahuja, PC Aoto, AP Kornev, G Veglia, SS Taylor Proceedings of the National Academy of Sciences 116 (30), 15052-15061, 2019 | 26 | 2019 |
| Globally correlated conformational entropy underlies positive and negative cooperativity in a kinase’s enzymatic cycle Y Wang, M VS, J Kim, G Li, LG Ahuja, P Aoto, SS Taylor, G Veglia Nature communications 10 (1), 1-11, 2019 | 24 | 2019 |
| Two PKA RIα holoenzyme states define ATP as an isoform-specific orthosteric inhibitor that competes with the allosteric activator, cAMP TW Lu, J Wu, PC Aoto, JH Weng, LG Ahuja, N Sun, CY Cheng, P Zhang, ... Proceedings of the National Academy of Sciences 116 (33), 16347-16356, 2019 | 20 | 2019 |
| Decoding the interactions regulating the active state mechanics of eukaryotic protein kinases HS Meharena, X Fan, LG Ahuja, MM Keshwani, CL McClendon, AM Chen, ... PLoS biology 14 (11), e2000127, 2016 | 20 | 2016 |
| Conformational basis for substrate recruitment in protein tyrosine phosphatase 10D LL Madan, B Gopal Biochemistry 50 (46), 10114-10125, 2011 | 13 | 2011 |
| Modulation of catalytic activity in multi-domain protein tyrosine phosphatases LL Madan, S Veeranna, K Shameer, CCS Reddy, R Sowdhamini, B Gopal PloS one 6 (9), e24766, 2011 | 12 | 2011 |
| PeptideMine-A webserver for the design of peptides for protein-peptide binding studies derived from protein-protein interactomes K Shameer, LL Madan, S Veeranna, B Gopal, R Sowdhamini BMC bioinformatics 11 (1), 1-14, 2010 | 11 | 2010 |
| Addition of a polypeptide stretch at the N-terminus improves the expression, stability and solubility of recombinant protein tyrosine phosphatases from Drosophila melanogaster LL Madan, B Gopal Protein expression and purification 57 (2), 234-243, 2008 | 8 | 2008 |
| A catalytically disabled double mutant of Src tyrosine kinase can be stabilized into an active-like conformation Y Meng, LG Ahuja, AP Kornev, SS Taylor, B Roux Journal of molecular biology 430 (6), 881-889, 2018 | 7* | 2018 |
| Molecular Analysis of Aedes aegypti Classical Protein Tyrosine Phosphatases Uncovers an Ortholog of Mammalian PTP-1B Implicated in the Control of Egg … DM Moretti, LG Ahuja, RD Nunes, CO Cudischevitch, CRO Daumas-Filho, ... Plos one 9 (8), e104878, 2014 | 6 | 2014 |
| Bi-domain protein tyrosine phosphatases reveal an evolutionary adaptation to optimize signal transduction LG Ahuja, B Gopal Antioxidants & Redox Signaling 20 (14), 2141-2159, 2014 | 6 | 2014 |
Alexandr KornevUniversity of California San DiegoVerified email at ucsd.edu
