Ramakrishna Edupuganti
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c-Jun N-terminal kinase promotes stem cell phenotype in triple-negative breast cancer through upregulation of Notch1 via activation of c-Jun
X Xie, TS Kaoud, R Edupuganti, T Zhang, T Kogawa, Y Zhao, ...
Oncogene 36 (18), 2599-2608, 2017
Synthesis and biological evaluation of pyrido [2, 3-d] pyrimidine-2, 4-dione derivatives as eEF-2K inhibitors
R Edupuganti, Q Wang, CDJ Tavares, CA Chitjian, JL Bachman, P Ren, ...
Bioorganic & medicinal chemistry 22 (17), 4910-4916, 2014
Definition of a Novel Feed-Forward Mechanism for Glycolysis-HIF1α Signaling in Hypoxic Tumors Highlights Aldolase A as a Therapeutic TargetTargeting a Glycolysis HIF-1 Feed …
G Grandjean, PR de Jong, BP James, MY Koh, R Lemos, J Kingston, ...
Cancer research 76 (14), 4259-4269, 2016
Asymmetric Total Synthesis of (S)-(+)-Cocaine and the First Synthesis of Cocaine C-1 Analogs from N-Sulfinyl β-Amino Ester Ketals
FA Davis, N Theddu, R Edupuganti
Organic letters 12 (18), 4118-4121, 2010
Conformational preferences of substrates for human prolyl 4-hydroxylase
KL Gorres, R Edupuganti, GR Krow, RT Raines
Biochemistry 47 (36), 9447-9455, 2008
High-throughput screens for eEF-2 kinase
AK Devkota, M Warthaka, R Edupuganti, CDJ Tavares, WH Johnson, ...
Journal of biomolecular screening 19 (3), 445-452, 2014
Asymmetric Synthesis of Substituted Homotropinones from N-Sulfinyl β-Amino Ketone Ketals. (−)-Euphococcinine and (−)-Adaline
FA Davis, R Edupuganti
Organic Letters 12 (4), 848-851, 2010
A c-Jun N-terminal kinase inhibitor, JNK-IN-8, sensitizes triple negative breast cancer cells to lapatinib
ND Ebelt, TS Kaoud, R Edupuganti, S Van Ravenstein, KN Dalby, ...
Oncotarget 8 (62), 104894, 2017
Mechanistic studies on covalent assemblies of metal-mediated hemi-aminal ethers
HH Jo, R Edupuganti, L You, KN Dalby, EV Anslyn
Chemical science 6 (1), 158-164, 2015
Discovery of a potent inhibitor of MELK that inhibits expression of the anti-apoptotic protein Mcl-1 and TNBC cell growth
R Edupuganti, JM Taliaferro, Q Wang, X Xie, EJ Cho, F Vidhu, P Ren, ...
Bioorganic & medicinal chemistry 25 (9), 2609-2616, 2017
Synthesis and applications of masked oxo-sulfinamides in asymmetric synthesis
R Edupuganti, FA Davis
Organic & Biomolecular Chemistry 10 (26), 5021-5031, 2012
Exploring naphthyl-carbohydrazides as inhibitors of influenza A viruses
S Barman, L You, R Chen, V Codrea, G Kago, R Edupuganti, J Robertus, ...
European journal of medicinal chemistry 71, 81-90, 2014
Reversible covalent inhibition of eEF‐2K by carbonitriles
AK Devkota, R Edupuganti, C Yan, Y Shi, J Jose, Q Wang, TS Kaoud, ...
ChemBioChem 15 (16), 2435-2442, 2014
Using docking and alchemical free energy approach to determine the binding mechanism of eEF2K inhibitors and prioritizing the compound synthesis
Q Wang, R Edupuganti, CDJ Tavares, KN Dalby, P Ren
Frontiers in molecular biosciences 2, 9, 2015
Synthesis of Conformationally Constrained 5-Fluoro- and 5-Hydroxymethanopyrrolidines. Ring-Puckered Mimics of Gauche- and Anti-3-Fluoro- and 3 …
GR Krow, R Edupuganti, D Gandla, F Yu, M Sender, PE Sonnet, MJ Zdilla, ...
The Journal of organic chemistry 76 (10), 3626-3634, 2011
Synthesis of 5-Fluoro- and 5-Hydroxymethanoprolines via Lithiation of N-BOC-methanopyrrolidines. Constrained Cγ-Exo and Cγ-Endo Flp and Hyp Conformer …
GR Krow, MD Shoulders, R Edupuganti, D Gandla, F Yu, PE Sonnet, ...
The Journal of organic chemistry 77 (12), 5331-5344, 2012
Quantification of a pharmacodynamic ERK end point in melanoma cell lysates: toward personalized precision medicine
M Warthaka, CH Adelmann, TS Kaoud, R Edupuganti, C Yan, ...
ACS medicinal chemistry letters 6 (1), 47-52, 2015
Modulating multi-functional ERK complexes by covalent targeting of a recruitment site in vivo
TS Kaoud, WH Johnson, ND Ebelt, A Piserchio, D Zamora-Olivares, ...
Nature communications 10 (1), 1-15, 2019
Serotonin analogues as inhibitors of breast cancer cell growth
J Jose, CDJ Tavares, ND Ebelt, A Lodi, R Edupuganti, X Xie, AK Devkota, ...
ACS medicinal chemistry letters 8 (10), 1072-1076, 2017
Computational and experimental studies of inhibitor Design for Aldolase A
R Qi, B Walker, Z Jing, M Yu, G Stancu, R Edupuganti, KN Dalby, P Ren
The Journal of Physical Chemistry B 123 (28), 6034-6041, 2019
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