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Kuldeep K. Roy
Kuldeep K. Roy
Professor and Head (Pharma Cluster), School of Health Sciences & Technology, UPES, Dehradun
Verified email at ddn.upes.ac.in
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Fragment-based design, docking, synthesis, biological evaluation and structure–activity relationships of 2-benzo/benzisothiazolimino-5-aryliden-4-thiazolidinones as …
P Eleftheriou, A Geronikaki, D Hadjipavlou-Litina, P Vicini, O Filz, ...
European journal of medicinal chemistry 47, 111-124, 2012
932012
Novel Carbamates as Orally Active Acetylcholinesterase Inhibitors Found to Improve Scopolamine-Induced Cognition Impairment: Pharmacophore-Based Virtual Screening, Synthesis …
SS Chaudhaery, KK Roy, N Shakya, G Saxena, SR Sammi, A Nazir, ...
Journal of medicinal chemistry 53 (17), 6490-6505, 2010
932010
Antimalarial naphthoquinones. Synthesis via click chemistry, in vitro activity, docking to PfDHODH and SAR of lapachol-based compounds
GC Brandão, FCR Missias, LM Arantes, LF Soares, KK Roy, RJ Doerksen, ...
European journal of medicinal chemistry 145, 191-205, 2018
812018
Novel, potent, orally bioavailable and selective mycobacterial ATP synthase inhibitors that demonstrated activity against both replicating and non-replicating M. tuberculosis
S Singh, KK Roy, SR Khan, VK Kashyap, A Sharma, S Jaiswal, ...
Bioorganic & Medicinal Chemistry, 2015
622015
An investigation of structurally diverse carbamates for acetylcholinesterase (AChE) inhibition using 3D-QSAR analysis
KK Roy, A Dixit, AK Saxena
Journal of Molecular Graphics and Modelling 27 (2), 197-208, 2008
612008
Consensus superiority of the pharmacophore-based alignment, over maximum common substructure (MCS): 3D-QSAR studies on carbamates as acetylcholinesterase inhibitors
SS Chaudhaery, KK Roy, AK Saxena
Journal of chemical information and modeling 49 (6), 1590-1601, 2009
602009
Synthesis and biological evaluation of substituted 4-arylthiazol-2-amino derivatives as potent growth inhibitors of replicating Mycobacterium tuberculosis
KK Roy, S Singh, SK Sharma, R Srivastava, V Chaturvedi, AK Saxena
Bioorganic & medicinal chemistry letters 21 (18), 5589-5593, 2011
562011
Activation of the γ-Aminobutyric Acid Type B (GABAB) Receptor by Agonists and Positive Allosteric Modulators: Miniperspective
KM Brown, KK Roy, GH Hockerman, RJ Doerksen, DA Colby
Journal of medicinal chemistry 58 (16), 6336-6347, 2015
522015
Targeting the active sites of malarial proteases for antimalarial drug discovery: approaches, progress and challenges
KK Roy
International Journal of Antimicrobial Agents 50 (3), 287-302, 2017
482017
Lead optimization studies towards the discovery of novel carbamates as potent AChE inhibitors for the potential treatment of Alzheimer’s disease
KK Roy, S Tota, T Tripathi, S Chander, C Nath, AK Saxena
Bioorganic & medicinal chemistry 20 (21), 6313-6320, 2012
442012
Substituted 1, 2, 3, 4-tetrahydroquinolin-6-yloxypropanes as β3-adrenergic receptor agonists: Design, synthesis, biological evaluation and pharmacophore modeling
N Shakya, KK Roy, AK Saxena
Bioorganic & medicinal chemistry 17 (2), 830-847, 2009
432009
Biological evaluation of novel substituted chloroquinolines targeting mycobacterial ATP synthase
SR Khan, S Singh, KK Roy, MS Akhtar, AK Saxena, MY Krishnan
International journal of antimicrobial agents 41 (1), 41-46, 2013
402013
Profiling the structural determinants for the selectivity of representative factor-Xa and thrombin inhibitors using combined ligand-based and structure-based approaches
SS Bhunia, KK Roy, AK Saxena
Journal of chemical information and modeling 51 (8), 1966-1985, 2011
402011
Negative Allosteric Modulators of Cannabinoid Receptor 2: Protein Modeling, Binding Site Identification and Molecular Dynamics Simulations in the Presence of an Orthosteric Agonist
P Pandey, KK Roy, RJ Doerksen
Journal of Biomolecular Structure and Dynamics 38 (1), 32-47, 2020
372020
Selective cannabinoid 2 receptor stimulation reduces tubular epithelial cell damage after renal ischemia-reperfusion injury
JD Pressly, SM Mustafa, AH Abidi, S Alghamdi, P Pandey, KK Roy, ...
Journal of Pharmacology and Experimental Therapeutics 364 (2), 287-299, 2018
352018
Identification and characterisation of small-molecule inhibitors of Rv3097c-encoded lipase (LipY) of Mycobacterium tuberculosis that selectively inhibit growth of bacilli in …
AK Saxena, KK Roy, S Singh, SP Vishnoi, A Kumar, VK Kashyap, ...
International journal of antimicrobial agents 42 (1), 27-35, 2013
342013
Structural basis for the β-adrenergic receptor subtype selectivity of the representative agonists and antagonists
KK Roy, AK Saxena
Journal of chemical information and modeling 51 (6), 1405-1422, 2011
282011
Synthesis and Anti-Renal Fibrosis Activity of Conformationally Locked Truncated 2-Hexynyl-N6-Substituted-(N)-Methanocarba-nucleosides as A3 Adenosine …
A Nayak, G Chandra, I Hwang, K Kim, X Hou, HO Kim, PK Sahu, KK Roy, ...
Journal of Medicinal Chemistry 57 (4), 1344-1354, 2014
252014
Synthesis and anti-tubercular activity of conformationally-constrained and bisquinoline analogs of TMC207
D Kalia, AK KS, G Meena, KP Sethi, R Sharma, P Trivedi, SR Khan, ...
MedChemComm 6 (8), 1554-1563, 2015
182015
Integration-mediated prediction enrichment of quantitative model for Hsp90 inhibitors as anti-cancer agents: 3D-QSAR study
KK Roy, S Singh, AK Saxena
Molecular diversity 15, 477-489, 2011
182011
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