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Alan Huang
Alan Huang
Tango Therapeutics
Verified email at tangotx.com - Homepage
Title
Cited by
Cited by
Year
Activation of MET via diverse exon 14 splicing alterations occurs in multiple tumor types and confers clinical sensitivity to MET inhibitors
GM Frampton, SM Ali, M Rosenzweig, J Chmielecki, X Lu, TM Bauer, ...
Cancer discovery 5 (8), 850-859, 2015
7282015
Identification and characterization of NVP-BKM120, an orally available pan-class I PI3-kinase inhibitor
SM Maira, S Pecchi, A Huang, M Burger, M Knapp, D Sterker, C Schnell, ...
Molecular cancer therapeutics 11 (2), 317-328, 2012
5932012
Relief of profound feedback inhibition of mitogenic signaling by RAF inhibitors attenuates their activity in BRAFV600E melanomas
P Lito, CA Pratilas, EW Joseph, M Tadi, E Halilovic, M Zubrowski, ...
Cancer cell 22 (5), 668-682, 2012
5892012
Convergent loss of PTEN leads to clinical resistance to a PI (3) Kα inhibitor
D Juric, P Castel, M Griffith, OL Griffith, HH Won, H Ellis, SH Ebbesen, ...
Nature 518 (7538), 240-244, 2015
5692015
Single-vector inducible lentiviral RNAi system for oncology target validation
D Wiederschain, W Susan, L Chen, A Loo, G Yang, A Huang, Y Chen, ...
Cell cycle 8 (3), 498-504, 2009
4702009
Characterization of the novel and specific PI3Kα inhibitor NVP-BYL719 and development of the patient stratification strategy for clinical trials
C Fritsch, A Huang, C Chatenay-Rivauday, C Schnell, A Reddy, M Liu, ...
Molecular cancer therapeutics 13 (5), 1117-1129, 2014
4672014
CDK 4/6 inhibitors sensitize PIK3CA mutant breast cancer to PI3K inhibitors
SR Vora, D Juric, N Kim, M Mino-Kenudson, T Huynh, C Costa, ...
Cancer cell 26 (1), 136-149, 2014
4412014
Synthetic lethality as an engine for cancer drug target discovery
A Huang, LA Garraway, A Ashworth, B Weber
Nature reviews Drug discovery 19 (1), 23-38, 2020
3662020
Phosphatidylinositol 3-kinase α–selective inhibition with alpelisib (BYL719) in PIK3CA-altered solid tumors: results from the first-in-human study
D Juric, J Rodon, J Tabernero, F Janku, HA Burris, JHM Schellens, ...
Journal of Clinical Oncology 36 (13), 1291, 2018
3472018
mTORC1 inhibition is required for sensitivity to PI3K p110α inhibitors in PIK3CA-mutant breast cancer
M Elkabets, S Vora, D Juric, N Morse, M Mino-Kenudson, T Muranen, ...
Science translational medicine 5 (196), 196ra99-196ra99, 2013
3102013
AXL mediates resistance to PI3Kα inhibition by activating the EGFR/PKC/mTOR axis in head and neck and esophageal squamous cell carcinomas
M Elkabets, E Pazarentzos, D Juric, Q Sheng, RA Pelossof, S Brook, ...
Cancer cell 27 (4), 533-546, 2015
3082015
Autosomal recessive retinitis pigmentosa caused by mutations in the α subunit of rod cGMP phosphodiesterase
SH Huang, SJ Pittler, X Huang, L Oliveira, EL Berson, TP Dryja
Nature genetics 11 (4), 468-471, 1995
2971995
A Smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumor necrosis factor-α signaling
A Gaither, D Porter, Y Yao, J Borawski, G Yang, J Donovan, D Sage, ...
Cancer research 67 (24), 11493-11498, 2007
2812007
Correlative analysis of genetic alterations and everolimus benefit in hormone receptor–positive, human epidermal growth factor receptor 2–negative advanced breast cancer …
GN Hortobagyi, D Chen, M Piccart, HS Rugo, HA Burris III, KI Pritchard, ...
Journal of Clinical Oncology 34 (5), 419, 2016
2622016
Alpelisib plus fulvestrant in PIK3CA-altered and PIK3CA-wild-type estrogen receptor–positive advanced breast cancer: a phase 1b clinical trial
D Juric, F Janku, J Rodón, HA Burris, IA Mayer, M Schuler, ...
JAMA oncology 5 (2), e184475-e184475, 2019
2202019
Measurement of PIP3 levels reveals an unexpected role for p110β in early adaptive responses to p110α-specific inhibitors in luminal breast cancer
C Costa, H Ebi, M Martini, SA Beausoleil, AC Faber, CT Jakubik, A Huang, ...
Cancer cell 27 (1), 97-108, 2015
2052015
Re-establishing the regenerative potential of central nervous system axons in postnatal mice
KS Cho, L Yang, B Lu, H Feng Ma, X Huang, M Pekny, DF Chen
Journal of cell science 118 (5), 863-872, 2005
1892005
Molecular Cloning, Expression, and Characterization of a Novel Human Serine/Threonine Protein Phosphatase, PP7, That Is Homologous toDrosophila Retinal Degeneration C Gene …
X Huang, RE Honkanen
Journal of Biological Chemistry 273 (3), 1462-1468, 1998
1771998
An antibody that locks HER3 in the inactive conformation inhibits tumor growth driven by HER2 or neuregulin
AP Garner, CU Bialucha, ER Sprague, JT Garrett, Q Sheng, S Li, ...
Cancer research 73 (19), 6024-6035, 2013
1382013
Abstract PR02: LEE011: An orally bioavailable, selective small molecule inhibitor of CDK4/6–Reactivating Rb in cancer.
S Kim, A Loo, R Chopra, G Caponigro, A Huang, S Vora, S Parasuraman, ...
Molecular Cancer Therapeutics 12 (11_Supplement), PR02-PR02, 2013
1362013
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