Vedagopuram Sreekanth
Vedagopuram Sreekanth
Postdoctoral Research Fellow: Brigham & Women's Hospital, Harvard Medical School, Broad Institute
Verified email at - Homepage
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Injectable small molecule hydrogel as a potential nanocarrier for localized and sustained in vivo delivery of doxorubicin
M Singh, S Kundu, V Sreekanth, RK Motiani, S Sengupta, A Srivastava, ...
Nanoscale 6, 12849-12855, 2014
Design, Synthesis, and Mechanistic Investigations of Bile acid-Tamoxifen Conjugates for Breast Cancer Therapy
V Sreekanth, S Bansal, RK Motiani, S Kundu, SK Muppu, TD Majumdar, ...
Bioconjugate chemistry 24 (9), 1468–1484, 2013
Transcription regulation of CDKN1A (p21/CIP1/WAF1) by TRF2 is epigenetically controlled through the REST repressor complex
T Hussain, D Saha, G Purohit, A Kar, AK Mukherjee, S Sharma, ...
Scientific reports 7 (1), 1-13, 2017
Bile acid amphiphiles with tunable head groups as highly selective antitubercular agents
S Bansal, M Singh, S Kidwai, P Bhargava, A Singh, V Sreekanth, R Singh, ...
MedChemComm 5, 1761-1768, 2014
Engineering designer beta cells with a CRISPR-Cas9 conjugation platform
D Lim, V Sreekanth, KJ Cox, BK Law, BK Wagner, JM Karp, A Choudhary
Nature Communications 11, 4043, 2020
Design, regioselective synthesis and cytotoxic evaluation of 2-aminoimidazole–quinoline hybrids against cancer and primary endothelial cells
K Singh, V Verma, K Yadav, V Sreekanth, D Kumar, A Bajaj, V Kumar
European journal of medicinal chemistry 87, 150-158, 2014
Synthesis, structure–activity relationship, and mechanistic investigation of lithocholic acid amphiphiles for colon cancer therapy
M Singh, S Bansal, S Kundu, P Bhargava, A Singh, RK Motiani, R Shyam, ...
MedChemComm 6, 192-201, 2015
Tethering of Chemotherapeutic Drug/Imaging Agent to Bile Acid-Phospholipid Increases the Efficacy and Bioavailability with Reduced Hepatotoxicity
AB V. Sreekanth, N. Medatwal, S. Kumar, S. Pal, V. Malyla, A. Kar, P ...
Bioconjugate Chem. 28 (12), 2942-2953, 2017
Nature of the Charged Head Group Determines the Fusogenic Potential and Membrane Properties of Lithocholic Acid Phospholipids
P Bhargava, M Singh, V Sreekanth, A Bajaj
The Journal of Physical Chemistry B 118 (31), 9341-9348, 2014
Fluorescence (fluidity/hydration) and calorimetric studies of interactions of bile acid–drug conjugates with model membranes
V Sreekanth, A Bajaj
The Journal of Physical Chemistry B 117 (7), 2123-2133, 2013
Number of Free Hydroxyl Groups on Bile Acid Phospholipids Determines the Fluidity and Hydration of Model Membranes
V Sreekanth, A Bajaj
The Journal of Physical Chemistry B 117 (40), 12135–12144, 2013
Recent Advances in Engineering of Lipid-Drug Conjugates for Cancer Therapy
V Sreekanth, A Bajaj
ACS Biomater. Sci. Eng. 5 (9), 4148-4166, 2019
CRISPR-based therapeutics: current challenges and future applications
AEM Modell, D Lim, T Nguyen, V Sreekanth, A Choudhary
Trends in Pharmacological Sciences 43 (2), 151-161, 2022
A 3D culture platform enables development of zinc-binding prodrugs for targeted proliferation of β cells
ACJMK Kisuk Yang, Miseon Lee, Peter Anthony Jones, Sophie S. Liu, Angela ...
Science Advances 6, eabc3207, 2020
Design, Synthesis, and Physico-Chemical Interactions of Bile Acid Derived Dimeric Phospholipid Amphiphiles with Model Membranes
AB S. Kumar, P. Bhargava, V. Sreekanth
Journal of Colloid and Interface Science 448, 398–406, 2015
Nature of the Charged Head Group Dictates the Anticancer Potential of Lithocholic Acid-Tamoxifen Conjugates For Breast Cancer Therapy
K Yadav, P Bhargava, S Bansal, M Singh, S Gupta, G Sandhu, S Kumar, ...
MedChemComm. 6, 778-787, 2015
Bile Acid Tethered Docetaxel‐based Nanomicelles Mitigate Tumor Progression through Epigenetic Changes.
V Sreekanth, A Kar, S Kumar, S Pal, P Yadav, Y Sharma, V Komalla, ...
Angewandte Chemie International Edition 60 (10), 5394-5399, 2021
Chemogenetic System Demonstrates That Cas9 Longevity Impacts Genome Editing Outcomes
AC Vedagopuram Sreekanth, Qingxuan Zhou, Praveen Kokkonda, Heysol C ...
ACS Central Science 6 (12), 2228–2237, 2020
Molecular Self-Assembly of Bile Acid-Phospholipids Controls the Delivery of Doxorubicin and Mice Survivability
AB V. Sreekanth, N. Medatwal, S. Pal, S. Kumar, S. Sengupta
Molecular Pharmaceutics 14 (8), 2649–2659, 2017
Self-assembled Supramolecular Nanomicelles from Bile Acid-Docetaxel Conjugate are Highly Tolerable with Improved Therapeutic Efficacy
BA Sreekanth V, Pal S, Kumar S, Komalla V, Yadav P, Radheyshyam, Sengupta S
Biomaterials Science 9 (16), 5626-5639, 2021
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