Vedagopuram Sreekanth

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Avinash Bajaj, PhDProfessor, Laboratory of Nanotechnology and Chemical Biology, Regional Center forVerified email at rcb.res.in
Amit ChoudharyAssistant Professor of Medicine, Harvard Medical SchoolVerified email at broadinstitute.org
Sagar SenguptaNational Institute of Immunology, National Institute of Biomedical GenomicsVerified email at nii.ac.in
Donghyun LimSungshin Women's UniversityVerified email at sungshin.ac.kr
Rajender Motiani; DVM, PhDAssociate Professor and DBT/Wellcome Trust Intermediate Fellow, Regional Centre for BiotechnologyVerified email at rcb.res.in
Jeffrey M. KarpProfessor of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Harvard-MITVerified email at partners.org
Basudeb MajiAssistant Professor at Bose InstituteVerified email at jcbose.ac.in
Aasheesh SrivastavaProfessor, Department of Chemistry, IISER BhopalVerified email at iiserb.ac.in
David R. LiuHarvard UniversityVerified email at fas.harvard.edu
Shantanu ChowdhuryCSIR Institute of Genomics and Integrative BiologyVerified email at igib.in
Benjamin L. EbertDana-Farber Cancer InstituteVerified email at dfci.harvard.edu
Richard I SherwoodBrigham and Women's HospitalVerified email at partners.org
Max JanMassachusetts General HospitalVerified email at partners.org
Dr.Vinod KumarDepartment of Chemistry, School of Basic Sciences, Central University of Haryana, MahendergarhVerified email at cuh.ac.in
James A. WalkerAssistant Prof. of Neurology, MGH, Harvard Medical SchoolVerified email at helix.mgh.harvard.edu
George ChurchHarvard Medical SchoolVerified email at harvard.edu
Luca PinelloAssociate Professor, MGH/Harvard Medical School/BROAD InstituteVerified email at mgh.harvard.edu
Martin KampmannAssociate Professor, University of California San FranciscoVerified email at ucsf.edu
Dirk TraunerUniversity of PennsylvaniaVerified email at upenn.edu
Ramandeep SinghTranslational Health Science and Technology InstituteVerified email at thsti.res.in

Vedagopuram Sreekanth

Postdoctoral Research Fellow: Brigham & Women's Hospital, Harvard Medical School, Broad Institute

Verified email at bwh.harvard.edu - Homepage

Chemical Biology CRISPR-Cas Diabetes/Sc-βcells Cancer-Pharmacology Drug/Protein/Nucleic acid delivery


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Injectable small molecule hydrogel as a potential nanocarrier for localized and sustained in vivo delivery of doxorubicin M Singh, S Kundu, V Sreekanth, RK Motiani, S Sengupta, A Srivastava, ... Nanoscale 6, 12849-12855, 2014	81	2014
Design, Synthesis, and Mechanistic Investigations of Bile acid-Tamoxifen Conjugates for Breast Cancer Therapy V Sreekanth, S Bansal, RK Motiani, S Kundu, SK Muppu, TD Majumdar, ... Bioconjugate chemistry 24 (9), 1468–1484, 2013	56	2013
Transcription regulation of CDKN1A (p21/CIP1/WAF1) by TRF2 is epigenetically controlled through the REST repressor complex T Hussain, D Saha, G Purohit, A Kar, AK Mukherjee, S Sharma, ... Scientific reports 7 (1), 1-13, 2017	53	2017
CRISPR-based therapeutics: current challenges and future applications AEM Modell, D Lim, T Nguyen, V Sreekanth, A Choudhary Trends in Pharmacological Sciences 43 (2), 151-161, 2022	41	2022
Engineering designer beta cells with a CRISPR-Cas9 conjugation platform D Lim, V Sreekanth, KJ Cox, BK Law, BK Wagner, JM Karp, A Choudhary Nature Communications 11, 4043, 2020	39	2020
Design, regioselective synthesis and cytotoxic evaluation of 2-aminoimidazole–quinoline hybrids against cancer and primary endothelial cells K Singh, V Verma, K Yadav, V Sreekanth, D Kumar, A Bajaj, V Kumar European journal of medicinal chemistry 87, 150-158, 2014	32	2014
Synthesis, structure–activity relationship, and mechanistic investigation of lithocholic acid amphiphiles for colon cancer therapy M Singh, S Bansal, S Kundu, P Bhargava, A Singh, RK Motiani, R Shyam, ... MedChemComm 6, 192-201, 2015	31	2015
Bile acid amphiphiles with tunable head groups as highly selective antitubercular agents S Bansal, M Singh, S Kidwai, P Bhargava, A Singh, V Sreekanth, R Singh, ... MedChemComm 5, 1761-1768, 2014	30	2014
A 3D culture platform enables development of zinc-binding prodrugs for targeted proliferation of β cells ACJMK Kisuk Yang, Miseon Lee, Peter Anthony Jones, Sophie S. Liu, Angela ... Science Advances 6, eabc3207, 2020	22	2020
Recent Advances in Engineering of Lipid-Drug Conjugates for Cancer Therapy V Sreekanth, A Bajaj ACS Biomater. Sci. Eng. 5 (9), 4148-4166, 2019	22	2019
Tethering of Chemotherapeutic Drug/Imaging Agent to Bile Acid-Phospholipid Increases the Efficacy and Bioavailability with Reduced Hepatotoxicity AB V. Sreekanth, N. Medatwal, S. Kumar, S. Pal, V. Malyla, A. Kar, P ... Bioconjugate Chem. 28 (12), 2942-2953, 2017	19	2017
Fluorescence (fluidity/hydration) and calorimetric studies of interactions of bile acid–drug conjugates with model membranes V Sreekanth, A Bajaj The Journal of Physical Chemistry B 117 (7), 2123-2133, 2013	18	2013
Nature of the Charged Head Group Determines the Fusogenic Potential and Membrane Properties of Lithocholic Acid Phospholipids P Bhargava, M Singh, V Sreekanth, A Bajaj The Journal of Physical Chemistry B 118 (31), 9341-9348, 2014	17	2014
Number of Free Hydroxyl Groups on Bile Acid Phospholipids Determines the Fluidity and Hydration of Model Membranes V Sreekanth, A Bajaj The Journal of Physical Chemistry B 117 (40), 12135–12144, 2013	17	2013
Proteolysis-targeting chimeras with reduced off-targets TM Nguyen, V Sreekanth, A Deb, P Kokkonda, PK Tiwari, KA Donovan, ... Nature Chemistry 16 (2), 218-228, 2024	15	2024
Chemogenetic System Demonstrates That Cas9 Longevity Impacts Genome Editing Outcomes AC Vedagopuram Sreekanth, Qingxuan Zhou, Praveen Kokkonda, Heysol C ... ACS Central Science 6 (12), 2228–2237, 2020	15	2020
Nature of the Charged Head Group Dictates the Anticancer Potential of Lithocholic Acid-Tamoxifen Conjugates For Breast Cancer Therapy K Yadav, P Bhargava, S Bansal, M Singh, S Gupta, G Sandhu, S Kumar, ... MedChemComm. 6, 778-787, 2015	15	2015
Bile Acid Tethered Docetaxel‐based Nanomicelles Mitigate Tumor Progression through Epigenetic Changes. V Sreekanth, A Kar, S Kumar, S Pal, P Yadav, Y Sharma, V Komalla, ... Angewandte Chemie International Edition 60 (10), 5394-5399, 2021	13	2021
Design, Synthesis, and Physico-Chemical Interactions of Bile Acid Derived Dimeric Phospholipid Amphiphiles with Model Membranes AB S. Kumar, P. Bhargava, V. Sreekanth Journal of Colloid and Interface Science 448, 398–406, 2015	11	2015
Molecular Self-Assembly of Bile Acid-Phospholipids Controls the Delivery of Doxorubicin and Mice Survivability AB V. Sreekanth, N. Medatwal, S. Pal, S. Kumar, S. Sengupta Molecular Pharmaceutics 14 (8), 2649–2659, 2017	9	2017

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