Combinatorial synthesis—the design of compound libraries and their application to drug discovery NK Terrett, M Gardner, DW Gordon, RJ Kobylecki, J Steele Tetrahedron 51 (30), 8135-8173, 1995 | 952 | 1995 |
Reductive alkylation on a solid phase: Synthesis of a piperazinedione combinatorial library DW Gordon, J Steele Bioorganic & Medicinal Chemistry Letters 5 (1), 47-50, 1995 | 231 | 1995 |
1, 4-Dihydropyridines as antagonists of platelet activating factor. 1. Synthesis and structure-activity relationships of 2-(4-heterocyclyl) phenyl derivatives K Cooper, MJ Fray, MJ Parry, K Richardson, J Steele Journal of medicinal chemistry 35 (17), 3115-3129, 1992 | 149 | 1992 |
Components of successful lead generation AM Davis, DJ Keeling, J Steele, NP Tomkinson, AC Tinker Current topics in medicinal chemistry 5 (4), 421-439, 2005 | 135 | 2005 |
Drug-like properties: guiding principles for design–or chemical prejudice? PD Leeson, AM Davis, J Steele Drug Discovery Today: Technologies 1 (3), 189-195, 2004 | 106 | 2004 |
Rate enhancement of biomimetic polyene cyclizations by a cation-stabilizing auxiliary WS Johnson, SD Lindell, J Steele Journal of the American Chemical Society 109 (19), 5852-5853, 1987 | 100 | 1987 |
New Lewis-Acidic Molybdenum (II) and Tungsten (II) Catalysts for Intramolecular Carbonyl Ene and Prins Reactions. Reversal of the Stereoselectivity of Cyclization of Citronellal P Kočovský, G Ahmed, J Šrogl, AV Malkov, J Steele The Journal of organic chemistry 64 (8), 2765-2775, 1999 | 94 | 1999 |
Asymmetric synthesis via acetal templates. 12. Highly diastereoselective coupling reactions with a ketene acetal. An efficient, asymmetric synthesis of R-(+)-α-lipoic acid JD Elliott, J Steele, WS Johnson Tetrahedron letters 26 (21), 2535-2538, 1985 | 74 | 1985 |
A mild and selective C-3 reductive alkylation of indoles JE Appleton, KN Dack, AD Green, J Steele Tetrahedron letters 34 (9), 1529-1532, 1993 | 65 | 1993 |
The combinatorial synthesis of a 30,752-compound library: discovery of SAR around the endothelin antagonist, FR-139,317 NK Terrett, D Bojanic, D Brown, PJ Bungay, M Gardner, DW Gordon, ... Bioorganic & Medicinal Chemistry Letters 5 (9), 917-922, 1995 | 60 | 1995 |
Selective Non-steroidal Glucocorticoid Receptor Modulators for the Inhaled Treatment of Pulmonary Diseases M Hemmerling, S Nilsson, K Edman, S Eirefelt, W Russell, R Hendrickx, ... Journal of Medicinal Chemistry, 2017 | 54 | 2017 |
Discovery of potent & selective inhibitors of activated thrombin-activatable fibrinolysis inhibitor for the treatment of thrombosis ME Bunnage, J Blagg, J Steele, DR Owen, C Allerton, AB McElroy, ... Journal of medicinal chemistry 50 (24), 6095-6103, 2007 | 54 | 2007 |
Novel antagonists of platelet-activating factor. 1. Synthesis and structure-activity relationships of benzodiazepine and benzazepine derivatives of 2-methyl-1-phenylimidazo [4 … MJ Fray, K Cooper, MJ Parry, K Richardson, J Steele Journal of medicinal chemistry 38 (18), 3514-3523, 1995 | 51 | 1995 |
A Practical Method for Targeted Library Design Balancing Lead‐like Properties with Diversity MJ Stocks, GRH Wilden, G Pairaudeau, MWD Perry, J Steele, ... ChemMedChem: Chemistry Enabling Drug Discovery 4 (5), 800-808, 2009 | 45 | 2009 |
Thromboxane modulating agents. 3. 1 H-Imidazol-1-ylalkyl-and 3-pyridinylalkyl-substituted 3-[2-[(arylsulfonyl) amino] ethyl] benzenepropanoic acid derivatives as dual … RP Dickinson, KN Dack, CJ Long, J Steele Journal of medicinal chemistry 40 (21), 3442-3452, 1997 | 33 | 1997 |
Indole derivatives thromboxane A2 antagonists PE Cross, KN Dack, RP Dickinson, J Steele US Patent 5,744,488, 1998 | 31 | 1998 |
Drug discovery by combinatorial chemistry—the development of a novel method for the rapid synthesis of single compounds NK Terrett, M Gardner, DW Gordon, RJ Kobylecki, J Steele Chemistry-A European Journal 3 (12), 1917-1920, 1997 | 29 | 1997 |
Pyrimidine derivatives as modulators of chemokine receptor activity MR Ebden, P Meghani, AR Cook, J Steele, LLS Cheema US Patent 7,482,355, 2009 | 26 | 2009 |
Discovery of AZD-2098 and AZD-1678, two potent and bioavailable CCR4 receptor antagonists N Kindon, G Andrews, A Baxter, D Cheshire, P Hemsley, T Johnson, ... ACS Medicinal Chemistry Letters 8 (9), 981-986, 2017 | 21 | 2017 |
Discovery and evaluation of a novel monocyclic series of CXCR2 antagonists RP Austin, C Bennion, RV Bonnert, L Cheema, AR Cook, RJ Cox, ... Bioorganic & medicinal chemistry letters 25 (7), 1616-1620, 2015 | 14 | 2015 |