| Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes S Hong, BL Ostaszewski, T Yang, TT O’Malley, M Jin, K Yanagisawa, S Li, ... Neuron 82 (2), 308-319, 2014 | 232 | 2014 |
| mGlu5 receptors and cellular prion protein mediate amyloid-β-facilitated synaptic long-term depression in vivo NW Hu, AJ Nicoll, D Zhang, AJ Mably, T O’Malley, SA Purro, C Terry, ... Nature communications 5 (1), 3374, 2014 | 200 | 2014 |
| C-terminally truncated forms of tau, but not full-length tau or its C-terminal fragments, are released from neurons independently of cell death D Kanmert, A Cantlon, CR Muratore, M Jin, TT O'Malley, G Lee, ... Journal of Neuroscience 35 (30), 10851-10865, 2015 | 167 | 2015 |
| Soluble Aβ oligomers impair hippocampal LTP by disrupting glutamatergic/GABAergic balance M Lei, H Xu, Z Li, Z Wang, TT O'Malley, D Zhang, DM Walsh, P Xu, ... Neurobiology of disease 85, 111-121, 2016 | 149 | 2016 |
| Autoregulated paracellular clearance of amyloid-β across the blood-brain barrier J Keaney, DM Walsh, T O’Malley, N Hudson, DE Crosbie, T Loftus, ... Science advances 1 (8), e1500472, 2015 | 141 | 2015 |
| APP homodimers transduce an amyloid-β-mediated increase in release probability at excitatory synapses H Fogel, S Frere, O Segev, S Bharill, I Shapira, N Gazit, T O’Malley, ... Cell reports 7 (5), 1560-1576, 2014 | 141 | 2014 |
| Amyloid-β nanotubes are associated with prion protein-dependent synaptotoxicity AJ Nicoll, S Panico, DB Freir, D Wright, C Terry, E Risse, CE Herron, ... Nature communications 4 (1), 2416, 2013 | 139 | 2013 |
| Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies S Linse, T Scheidt, K Bernfur, M Vendruscolo, CM Dobson, SIA Cohen, ... Nature structural & molecular biology 27 (12), 1125-1133, 2020 | 134 | 2020 |
| New ELISAs with high specificity for soluble oligomers of amyloid β-protein detect natural Aβ oligomers in human brain but not CSF T Yang, S Hong, T O'Malley, RA Sperling, DM Walsh, DJ Selkoe Alzheimer's & Dementia 9 (2), 99-112, 2013 | 127 | 2013 |
| Diffusible, highly bioactive oligomers represent a critical minority of soluble Aβ in Alzheimer’s disease brain W Hong, Z Wang, W Liu, TT O’Malley, M Jin, M Willem, C Haass, ... Acta neuropathologica 136, 19-40, 2018 | 118 | 2018 |
| A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid T Yang, TT O’Malley, D Kanmert, J Jerecic, LR Zieske, H Zetterberg, ... Alzheimer's research & therapy 7, 1-16, 2015 | 94 | 2015 |
| Identification of neurotoxic cross-linked amyloid-β dimers in the Alzheimer’s brain G Brinkmalm, W Hong, Z Wang, W Liu, TT O’Malley, X Sun, MP Frosch, ... Brain 142 (5), 1441-1457, 2019 | 90 | 2019 |
| Extracellular forms of Aβ and tau from iPSC models of Alzheimer’s disease disrupt synaptic plasticity NW Hu, GT Corbett, S Moore, I Klyubin, TT O’Malley, DM Walsh, ... Cell Reports 23 (7), 1932-1938, 2018 | 78 | 2018 |
| Aβ dimers differ from monomers in structural propensity, aggregation paths and population of synaptotoxic assemblies TT O’Malley, NA Oktaviani, D Zhang, A Lomakin, B O’Nuallain, S Linse, ... Biochemical Journal 461 (3), 413-426, 2014 | 75 | 2014 |
| An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer’s disease M Jin, B O’Nuallain, W Hong, J Boyd, VN Lagomarsino, TT O’Malley, ... Nature communications 9 (1), 2676, 2018 | 58 | 2018 |
| The aqueous phase of Alzheimer's disease brain contains assemblies built from∼ 4 and∼ 7 kDa Aβ species JM Mc Donald, TT O'Malley, W Liu, AJ Mably, G Brinkmalm, E Portelius, ... Alzheimer's & Dementia 11 (11), 1286-1305, 2015 | 58 | 2015 |
| Targeted Magnetic Nanoparticles for Remote Magnetothermal Disruption of Amyloid‐β Aggregates CN Loynachan, G Romero, MG Christiansen, R Chen, R Ellison, ... Advanced Healthcare Materials 4 (14), 2100-2109, 2015 | 28 | 2015 |
| The aggregation paths and products of Aβ42 dimers are distinct from those of the Aβ42 monomer TT O’Malley, WM Witbold III, S Linse, DM Walsh Biochemistry 55 (44), 6150-6161, 2016 | 23 | 2016 |
| Kinetic fingerprints differentiate anti-Aβ therapies S Linse, T Scheidt, K Bernfur, M Vendruscolo, CM Dobson, SIA Cohen, ... bioRxiv, 815308, 2020 | 8* | 2020 |
| IgG Conformer's binding to amyloidogenic aggregates M Phay, AT Welzel, AD Williams, HP McWilliams-Koeppen, V Blinder, ... PloS one 10 (9), e0137344, 2015 | 8 | 2015 |
Dominic Martin WalshBrigham and Women's HospitalVerified email at bwh.harvard.edu
