| Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation AD Kohn, SA Summers, MJ Birnbaum, RA Roth Journal of Biological Chemistry 271 (49), 31372-31378, 1996 | 1676 | 1996 |
| Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance WL Holland, JT Brozinick, LP Wang, ED Hawkins, KM Sargent, Y Liu, ... Cell metabolism 5 (3), 167-179, 2007 | 1365 | 2007 |
| Ceramides in insulin resistance and lipotoxicity SA Summers Progress in lipid research 45 (1), 42-72, 2006 | 1014 | 2006 |
| Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin WL Holland, RA Miller, ZV Wang, K Sun, BM Barth, HH Bui, KE Davis, ... Nature medicine 17 (1), 55-63, 2011 | 995 | 2011 |
| Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice WL Holland, BT Bikman, LP Wang, G Yuguang, KM Sargent, S Bulchand, ... The Journal of clinical investigation 121 (5), 1858-1870, 2011 | 829 | 2011 |
| A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids JA Chavez, TA Knotts, LP Wang, G Li, RT Dobrowsky, GL Florant, ... Journal of Biological Chemistry 278 (12), 10297-10303, 2003 | 724 | 2003 |
| A ceramide-centric view of insulin resistance JA Chavez, SA Summers Cell metabolism 15 (5), 585-594, 2012 | 661 | 2012 |
| Sphingolipids, Insulin Resistance, and Metabolic Disease: New Insights from in Vivo Manipulation of Sphingolipid Metabolism WL Holland, SA Summers Endocrine reviews 29 (4), 381-402, 2008 | 626 | 2008 |
| Ceramides–lipotoxic inducers of metabolic disorders B Chaurasia, SA Summers Trends in Endocrinology & Metabolism 26 (10), 538-550, 2015 | 623 | 2015 |
| Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes JA Chavez, SA Summers Archives of biochemistry and biophysics 419 (2), 101-109, 2003 | 589 | 2003 |
| Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide SA Summers, LA Garza, H Zhou, MJ Birnbaum Molecular and cellular biology 18 (9), 5457-5464, 1998 | 563 | 1998 |
| Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B S Stratford, KL Hoehn, F Liu, SA Summers Journal of Biological Chemistry 279 (35), 36608-36615, 2004 | 507 | 2004 |
| CerS2 haploinsufficiency inhibits β-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance S Raichur, ST Wang, PW Chan, Y Li, J Ching, B Chaurasia, S Dogra, ... Cell metabolism 20 (4), 687-695, 2014 | 504 | 2014 |
| Ceramides as modulators of cellular and whole-body metabolism BT Bikman, SA Summers The Journal of clinical investigation 121 (11), 4222-4230, 2011 | 479 | 2011 |
| Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis H Zhou, SA Summers, MJ Birnbaum, RN Pittman Journal of Biological Chemistry 273 (26), 16568-16575, 1998 | 446 | 1998 |
| Construction and characterization of a conditionally active version of the serine/threonine kinase Akt AD Kohn, A Barthel, KS Kovacina, A Boge, B Wallach, SA Summers, ... Journal of Biological Chemistry 273 (19), 11937-11943, 1998 | 383 | 1998 |
| Sphingolipids and phospholipids in insulin resistance and related metabolic disorders PJ Meikle, SA Summers Nature Reviews Endocrinology 13 (2), 79-91, 2017 | 369 | 2017 |
| Lipid mediators of insulin resistance WL Holland, TA Knotts, JA Chavez, LP Wang, KL Hoehn, SA Summers Nutrition reviews 65 (suppl_1), S39-S46, 2007 | 368 | 2007 |
| Targeting a ceramide double bond improves insulin resistance and hepatic steatosis B Chaurasia, TS Tippetts, R Mayoral Monibas, J Liu, Y Li, L Wang, ... Science 365 (6451), 386-392, 2019 | 357 | 2019 |
| Caffeine stimulates hepatic lipid metabolism by the autophagy‐lysosomal pathway in mice RA Sinha, BL Farah, BK Singh, MM Siddique, Y Li, Y Wu, OR Ilkayeva, ... Hepatology 59 (4), 1366-1380, 2014 | 354 | 2014 |
Morris BirnbaumVerified email at pennmedicine.upenn.edu
