| Dual Targeting of Epithelial Ovarian Cancer Via Folate Receptor α and the Proton-Coupled Folate Transporter with 6-Substituted Pyrrolo[2,3-d]pyrimidine Antifolates Z Hou, L Gattoc, C O'Connor, S Yang, A Wallace-Povirk, C George, S Orr, ... Molecular cancer therapeutics 16 (5), 819-830, 2017 | 54 | 2017 |
| Novel Pyrrolo[3,2-d]pyrimidine Compounds Target Mitochondrial and Cytosolic One-carbon Metabolism with Broad-spectrum Antitumor Efficacy AS Dekhne, K Shah, GS Ducker, JM Katinas, J Wong-Roushar, ... Molecular cancer therapeutics 18 (10), 1787-1799, 2019 | 47 | 2019 |
| Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and … LK Golani, A Wallace-Povirk, SM Deis, J Wong, J Ke, X Gu, S Raghavan, ... Journal of medicinal chemistry 59 (17), 7856-7876, 2016 | 44 | 2016 |
| Fluorine-Substituted Pyrrolo[2,3-d]Pyrimidine Analogues with Tumor Targeting via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and … M Ravindra, MR Wilson, N Tong, C O’Connor, M Karim, L Polin, ... Journal of medicinal chemistry 61 (9), 4228-4248, 2018 | 31 | 2018 |
| Cellular pharmacodynamics of a novel pyrrolo [3, 2-d] pyrimidine inhibitor targeting mitochondrial and cytosolic one-carbon metabolism AS Dekhne, C Ning, MJ Nayeen, K Shah, H Kalpage, J Frühauf, ... Molecular Pharmacology 97 (1), 9-22, 2020 | 30 | 2020 |
| Folate transporter dynamics and therapy with classic and tumor-targeted antifolates C O’Connor, A Wallace-Povirk, C Ning, J Frühauf, N Tong, A Gangjee, ... Scientific reports 11 (1), 6389, 2021 | 20 | 2021 |
| Folate transport and one-carbon metabolism in targeted therapies of epithelial ovarian cancer A Wallace-Povirk, Z Hou, MJ Nayeen, A Gangjee, LH Matherly Cancers 14 (1), 191, 2021 | 17 | 2021 |
| Discovery of 6-substituted thieno [2, 3-d] pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide … A Wallace-Povirk, N Tong, J Wong-Roushar, C O'Connor, X Zhou, Z Hou, ... Bioorganic & medicinal chemistry 37, 116093, 2021 | 14 | 2021 |
| Tumor Targeting with Novel Pyridyl 6-Substituted Pyrrolo[2,3-d]Pyrimidine Antifolates via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and … M Ravindra, A Wallace-Povirk, MA Karim, MR Wilson, C O’Connor, ... Journal of medicinal chemistry 61 (5), 2027-2040, 2018 | 14 | 2018 |
| Targeted therapy of pyrrolo[2,3-d]pyrimidine antifolates in a syngeneic mouse model of high grade serous ovarian cancer and the impact on the tumor … A Wallace-Povirk, L Rubinsak, A Malysa, SH Dzinic, M Ravindra, ... Scientific reports 12 (1), 11346, 2022 | 9 | 2022 |
| l-Proline-Catalyzed Cyclization of 6-Aminopyrimidine-4 (3H)-ones with Nitroolefins: Synthesis of Polysubstituted 5-Arylpyrrolo [2, 3-d] pyrimidin-4-ones C Li, F Zhang Synlett 28 (11), 1315-1320, 2017 | 7 | 2017 |
| Sirtuin 6 is required for the integrated stress response and resistance to inhibition of transcriptional cyclin-dependent kinases N Kartha, JE Gianopulos, Z Schrank, SM Cavender, S Dobersch, ... Science translational medicine 15 (694), eabn9674, 2023 | 3 | 2023 |
| Multitargeted 6-Substituted Thieno[2,3-d]pyrimidines as Folate Receptor-Selective Anticancer Agents that Inhibit Cytosolic and Mitochondrial One-Carbon Metabolism N Tong, J Wong-Roushar, A Wallace-Povirk, Y Shah, MC Nyman, ... ACS Pharmacology & Translational Science 6 (5), 748-770, 2023 | 3 | 2023 |
| Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria MJ Nayeen, JM Katinas, T Magdum, K Shah, JE Wong, CE O’Connor, ... Journal of Medicinal Chemistry 66 (16), 11294-11323, 2023 | 2 | 2023 |
| Targeting mitochondrial and cytosolic one-carbon metabolism in epithelial ovarian cancer via folate receptor alpha AC Wallace-Povirk, C O'Connor, X Bao, J Katinas, J Wong-Roushar, ... Cancer Research 81 (13_Supplement), 2348-2348, 2021 | 1 | 2021 |
| Tumor-treating fields decrease proliferation and clonogenicity of patient-derived WHO grade IV glioma cell lines SK Michelhaugh, S Kiousis, A Wallace-Povirk, S Mittal Cancer Research 77 (13_Supplement), 3309-3309, 2017 | 1 | 2017 |
| Mitochondrial and cytosolic one-carbon metabolism is a targetable metabolic vulnerability in cisplatin-resistant ovarian cancer A Wallace-Povirk, C O'Connor, AS Dekhne, X Bao, MJ Nayeen, ... Molecular Cancer Therapeutics, OF1-OF14, 2024 | | 2024 |
| Abstract A095: ZNF274 suppresses the mesenchymal state, thereby causing intrinsic resistance to CDK7 inhibition J Gianopulos, A Wallace-Povirk, S Kugel Cancer Research 84 (2_Supplement), A095-A095, 2024 | | 2024 |
| Correction: Novel Pyrrolo[3,2-d]Pyrimidine Compounds Target Mitochondrial and Cytosolic One-Carbon Metabolism with Broad-spectrum Antitumor Efficacy AS Dekhne, K Shah, GS Ducker, JM Katinas, J Wong-Roushar, ... Molecular Cancer Therapeutics 22 (2), 287-287, 2023 | | 2023 |
| Sirtuin 6 histone deacetylase is required for the integrated stress response and resistance to inhibition of transcriptional cyclin dependent kinases in Pancreatic Ductal … J Gianopulos, N Kartha, Z Schrank, S Dobersch, S Cavender, B Kynnap, ... CANCER RESEARCH 82 (22), 107-108, 2022 | | 2022 |
