Joleen Masschelein
Joleen Masschelein
FWO Postdoctoral Research Fellow, KU Leuven
Verified email at
Cited by
Cited by
Minimum information about a biosynthetic gene cluster
MH Medema, R Kottmann, P Yilmaz, M Cummings, JB Biggins, K Blin, ...
Nature chemical biology 11 (9), 625-631, 2015
Isolation and purification of a new kalimantacin/batumin-related polyketide antibiotic and elucidation of its biosynthesis gene cluster
W Mattheus, LJ Gao, P Herdewijn, B Landuyt, J Verhaegen, ...
Chemistry & biology 17 (2), 149-159, 2010
A PKS/NRPS/FAS hybrid gene cluster from Serratia plymuthica RVH1 encoding the biosynthesis of three broad spectrum, zeamine-related antibiotics
J Masschelein, W Mattheus, LJ Gao, P Moons, R Van Houdt, ...
PLoS One 8 (1), 2013
A conserved motif flags acyl carrier proteins for β-branching in polyketide synthesis
AS Haines, X Dong, Z Song, R Farmer, C Williams, J Hothersall, ...
Nature chemical biology 9 (11), 685, 2013
Antibiotics from Gram-negative bacteria: a comprehensive overview and selected biosynthetic highlights
J Masschelein, M Jenner, GL Challis
Natural product reports 34 (7), 712-783, 2017
The kalimantacin/batumin biosynthesis operon encodes a self-resistance isoform of the FabI bacterial target
W Mattheus, J Masschelein, LJ Gao, P Herdewijn, B Landuyt, G Volckaert, ...
Chemistry & biology 17 (10), 1067-1071, 2010
Discovery and Biosynthesis of Gladiolin: A Burkholderia gladioli Antibiotic with Promising Activity against Mycobacterium tuberculosis
L Song, M Jenner, J Masschelein, C Jones, MJ Bull, SR Harris, ...
Journal of the American Chemical Society 139 (23), 7974-7981, 2017
Thioester reduction and aldehyde transamination are universal steps in actinobacterial polyketide alkaloid biosynthesis
GLC Ufedo R. Awodi1, Jade L. Ronan1, Joleen Masschelein1, Emmanuel L.C. de ...
Chemical Science, 2016
The zeamine antibiotics affect the integrity of bacterial membranes
J Masschelein, C Clauwers, K Stalmans, K Nuyts, W De Borggraeve, ...
Appl. Environ. Microbiol. 81 (3), 1139-1146, 2015
A combination of polyunsaturated fatty acid, nonribosomal peptide and polyketide biosynthetic machinery is used to assemble the zeamine antibiotics
J Masschelein, C Clauwers, UR Awodi, K Stalmans, W Vermaelen, ...
Chemical science 6 (2), 923-929, 2015
Genome sequence of Serratia plymuthica RVH1, isolated from a raw vegetable-processing line
R Van Houdt, D Van der Lelie, JA Izquierdo, A Aertsen, J Masschelein, ...
Genome Announc. 2 (1), e00021-14, 2014
Elucidation of the relative and absolute stereochemistry of the kalimantacin/batumin antibiotics
IRG Thistlethwaite, FM Bull, C Cui, PD Walker, SS Gao, L Wang, Z Song, ...
Chemical science 8 (9), 6196-6201, 2017
A dual transacylation mechanism for polyketide synthase chain release in enacyloxin antibiotic biosynthesis
J Masschelein, PK Sydor, C Hobson, R Howe, C Jones, DM Roberts, ...
Nature chemistry 11 (10), 906-912, 2019
Biosynthesis of a'fungal'peptide antibiotic by Burkholderia gladioli
M Jenner, J Masschelein, Y Dashti, C Jones, S Harris, J Parkhill, ...
Planta Medica 82 (S 01), P1112, 2016
Structural basis for chain release from the enacyloxin polyketide synthase
S Kosol, A Gallo, D Griffiths, TR Valentic, J Masschelein, M Jenner, ...
Nature chemistry 11 (10), 913-923, 2019
Systematic analysis of the kalimantacin assembly line NRPS module using an adapted targeted mutagenesis approach
B Uytterhoeven, K Appermans, L Song, J Masschelein, T Lathouwers, ...
MicrobiologyOpen 5 (2), 279-286, 2016
The kalimantacin polyketide antibiotics inhibit fatty acid biosynthesis in Staphylococcus aureus by targeting the enoyl‐acyl carrier protein binding site of FabI
CD Fage, T Lathouwers, M Vanmeert, LJ Gao, K Vrancken, EM Lammens, ...
Angewandte Chemie, 2020
Antimicrobial agents
GL Challis, J Xinyun, C Hobson, JSL Masschelein
US Patent App. 16/606,845, 2020
Pentamycin Biosynthesis in Philippine Streptomyces sp. S816: Cytochrome P450-Catalyzed Installation of the C-14 Hydroxyl Group
S Zhou, L Song, J Masschelein, FAM Sumang, IA Papa, TO Zulaybar, ...
ACS chemical biology 14 (6), 1305-1309, 2019
Antimicrobial agents
GL Challis, DJ Griffiths, JSL Masschelein
US Patent App. 16/094,617, 2019
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