| Roles of CYP3A4 and CYP2C19 in methyl hydroxylated and N-oxidized metabolite formation from voriconazole, a new anti-fungal agent, in human liver microsomes N Murayama, N Imai, T Nakane, M Shimizu, H Yamazaki Biochemical pharmacology 73 (12), 2020-2026, 2007 | 153 | 2007 |
| The CYP3A4 intron 6 C> T polymorphism (CYP3A4* 22) is associated with reduced CYP3A4 protein level and function in human liver microsomes M Okubo, N Murayama, M Shimizu, T Shimada, FP Guengerich, ... The Journal of toxicological sciences 38 (3), 349-354, 2013 | 104 | 2013 |
| Transient trimethylaminuria related to menstruation M Shimizu, JR Cashman, H Yamazaki BMC Medical Genetics 8, 1-3, 2007 | 87 | 2007 |
| Eubacterium limosum ameliorates experimental colitis and metabolite of microbe attenuates colonic inflammatory action with increase of mucosal integrity O Kanauchi, M Fukuda, Y Matsumoto, S Ishii, T Ozawa, M Shimizu, ... World journal of gastroenterology: WJG 12 (7), 1071, 2006 | 82 | 2006 |
| Potential impact of cytochrome P450 3A5 in human liver on drug interactions with triazoles H Yamazaki, M Nakamoto, M Shimizu, N Murayama, T Niwa British journal of clinical pharmacology 69 (6), 593-597, 2010 | 69 | 2010 |
| Survey of variants of human flavin-containing monooxygenase 3 (FMO3) and their drug oxidation activities H Yamazaki, M Shimizu Biochemical pharmacology 85 (11), 1588-1593, 2013 | 68 | 2013 |
| Effect of genetic variants of the human flavin-containing monooxygenase 3 on N-and S-oxygenation activities M Shimizu, H Yano, S Nagashima, N Murayama, J Zhang, JR Cashman, ... Drug metabolism and disposition 35 (3), 328-330, 2007 | 62 | 2007 |
| Human blood concentrations of cotinine, a biomonitoring marker for tobacco smoke, extrapolated from nicotine metabolism in rats and humans and physiologically based … H Yamazaki, K Horiuchi, R Takano, T Nagano, M Shimizu, M Kitajima, ... International journal of environmental research and public health 7 (9 …, 2010 | 58 | 2010 |
| Sulfating-Activity and Stability of cDNA-Expressed Allozymes of Human Phenol Sulfotransferase, ST1A3*1 (213Arg) and ST1A3*2 (213His), Both of Which Exist … S Ozawa, M Shimizu, T Katoh, A Miyajima, Y Ohno, Y Matsumoto, ... The journal of biochemistry 126 (2), 271-277, 1999 | 56 | 1999 |
| Cytochrome P450-depedent drug oxidation activity of liver microsomes from Microminipigs, a possible new animal model for humans in non-clinical studies N Murayama, N Kaneko, K Horiuchi, K Ohyama, M Shimizu, K Ito, ... Drug metabolism and pharmacokinetics 24 (4), 404-408, 2009 | 53 | 2009 |
| Individual differences in pharmacokinetics and pharmacodynamics of anesthetic agent propofol with regard to CYP2B6 and UGT1A9 genotype and patient age F Kansaku, T Kumai, K Sasaki, M Yokozuka, M Shimizu, T Tateda, ... Drug metabolism and pharmacokinetics 26 (5), 532-537, 2011 | 50 | 2011 |
| Drug interactions of thalidomide with midazolam and cyclosporine A: heterotropic cooperativity of human cytochrome P450 3A5 Y Okada, N Murayama, C Yanagida, M Shimizu, FP Guengerich, ... Drug metabolism and disposition 37 (1), 18-23, 2009 | 49 | 2009 |
| Human liver microsomal cytochrome P450 3A enzymes involved in thalidomide 5-hydroxylation and formation of a glutathione conjugate G Chowdhury, N Murayama, Y Okada, Y Uno, M Shimizu, N Shibata, ... Chemical research in toxicology 23 (6), 1018-1024, 2010 | 46 | 2010 |
| Stop codon mutations in the flavin-containing monooxygenase 3 (FMO3) gene responsible for trimethylaminuria in a Japanese population H Yamazaki, H Fujita, T Gunji, J Zhang, T Kamataki, JR Cashman, ... Molecular genetics and metabolism 90 (1), 58-63, 2007 | 46 | 2007 |
| Human blood concentrations of dichlorodiphenyltrichloroethane (DDT) extrapolated from metabolism in rats and humans and physiologically based pharmacokinetic modeling H Yamazaki, R Takano, K Horiuchi, M Shimizu, N Murayama, M Kitajima, ... Journal of health science 56 (5), 566-575, 2010 | 45 | 2010 |
| Biomonitoring of urinary cotinine concentrations associated with plasma levels of nicotine metabolites after daily cigarette smoking in a male Japanese population T Nagano, M Shimizu, K Kiyotani, T Kamataki, R Takano, N Murayama, ... International journal of environmental research and public health 7 (7 …, 2010 | 44 | 2010 |
| In Vivo Formation of Dihydroxylated and Glutathione Conjugate Metabolites Derived from Thalidomide and 5-Hydroxythalidomide in Humanized TK-NOG Mice H Yamazaki, H Suemizu, M Shimizu, S Igaya, N Shibata, M Nakamura, ... Chemical research in toxicology 25 (2), 274-276, 2012 | 42 | 2012 |
| Simultaneous pharmacokinetics assessment of caffeine, warfarin, omeprazole, metoprolol, and midazolam intravenously or orally administered to Microminipigs M Mogi, A Toda, K Iwasaki, S Kusumoto, H Takehara, M Shimizu, ... The Journal of toxicological sciences 37 (6), 1157-1164, 2012 | 40 | 2012 |
| Molecular evolution and balancing selection in the flavin-containing monooxygenase 3 gene (FMO3) CK Allerston, M Shimizu, M Fujieda, EA Shephard, H Yamazaki, ... Pharmacogenetics and genomics 17 (10), 827-839, 2007 | 39 | 2007 |
| Genetic polymorphism of the flavin-containing monooxygenase 3 (FMO3) associated with trimethylaminuria (fish odor syndrome): observations from Japanese patients H Yamazaki, M Shimizu Current drug metabolism 8 (5), 487-491, 2007 | 38 | 2007 |
Hiroshi Yamazaki昭和薬科大学教授Verified email at ac.shoyaku.ac.jp
Hiroshi Yamazaki昭和薬科大学教授Verified email at ac.shoyaku.ac.jp