| TGF-β: duality of function between tumor prevention and carcinogenesis DR Principe, JA Doll, J Bauer, B Jung, HG Munshi, L Bartholin, B Pasche, ... Journal of the National Cancer Institute 106 (2), djt369, 2014 | 556 | 2014 |
| TGFβ Signaling in the Pancreatic Tumor Microenvironment Promotes Fibrosis and Immune Evasion to Facilitate Tumorigenesis DR Principe, B DeCant, E Mascariñas, EA Wayne, AM Diaz, N Akagi, ... Cancer research 76 (9), 2525-2539, 2016 | 193 | 2016 |
| The current treatment paradigm for pancreatic ductal adenocarcinoma and barriers to therapeutic efficacy DR Principe, PW Underwood, M Korc, JG Trevino, HG Munshi, A Rana Frontiers in oncology 11, 688377, 2021 | 129 | 2021 |
| TGFβ Blockade Augments PD-1 Inhibition to Promote T-Cell–Mediated Regression of Pancreatic Cancer DR Principe, A Park, MJ Dorman, S Kumar, N Viswakarma, J Rubin, ... Molecular cancer therapeutics 18 (3), 613-620, 2019 | 111 | 2019 |
| SIRT2-Mediated Deacetylation and Tetramerization of Pyruvate Kinase Directs Glycolysis and Tumor Growth SH Park, O Ozden, G Liu, HY Song, Y Zhu, Y Yan, X Zou, HJ Kang, ... Cancer research 76 (13), 3802-3812, 2016 | 109 | 2016 |
| The oncopig cancer model: an innovative large animal translational oncology platform KM Schachtschneider, RM Schwind, J Newson, N Kinachtchouk, M Rizko, ... Frontiers in oncology 7, 190, 2017 | 108 | 2017 |
| Long-Term Gemcitabine Treatment Reshapes the Pancreatic Tumor Microenvironment and Sensitizes Murine Carcinoma to Combination Immunotherapy DR Principe, M Narbutis, S Kumar, A Park, N Viswakarma, MJ Dorman, ... Cancer research 80 (15), 3101-3115, 2020 | 88 | 2020 |
| SIRT3 and SIRT4 are mitochondrial tumor suppressor proteins that connect mitochondrial metabolism and carcinogenesis Y Zhu, Y Yan, DR Principe, X Zou, A Vassilopoulos, D Gius Cancer & metabolism 2, 1-11, 2014 | 76 | 2014 |
| Activin and TGFβ use diverging mitogenic signaling in advanced colon cancer J Bauer, O Ozden, N Akagi, T Carroll, DR Principe, JJ Staudacher, ... Molecular cancer 14, 1-14, 2015 | 67 | 2015 |
| TGFβ engages MEK/ERK to differentially regulate benign and malignant pancreas cell function DR Principe, AM Diaz, C Torres, RJ Mangan, B DeCant, R McKinney, ... Oncogene 36 (30), 4336-4348, 2017 | 63 | 2017 |
| A validated, transitional and translational porcine model of hepatocellular carcinoma KM Schachtschneider, RM Schwind, KA Darfour-Oduro, AK De, LA Rund, ... Oncotarget 8 (38), 63620, 2017 | 57 | 2017 |
| Regulatory T-cells as an emerging barrier to immune checkpoint inhibition in lung cancer DR Principe, L Chiec, NA Mohindra, HG Munshi Frontiers in oncology 11, 684098, 2021 | 49 | 2021 |
| Trials and tribulations of pancreatic cancer immunotherapy DR Principe, M Korc, SD Kamath, HG Munshi, A Rana Cancer letters 504, 1-14, 2021 | 47 | 2021 |
| Of mice, dogs, pigs, and men: choosing the appropriate model for immuno-oncology research NH Overgaard, TM Fan, KM Schachtschneider, DR Principe, LB Schook, ... ILAR journal 59 (3), 247-262, 2018 | 45 | 2018 |
| HDAC3 mediates smoking-induced pancreatic cancer M Edderkaoui, S Xu, C Chheda, S Morvaridi, RW Hu, PJ Grippo, ... Oncotarget 7 (7), 7747, 2016 | 45 | 2016 |
| Loss of TGFβ signaling promotes colon cancer progression and tumor-associated inflammation DR Principe, B DeCant, J Staudacher, D Vitello, RJ Mangan, EA Wayne, ... Oncotarget 8 (3), 3826, 2017 | 43 | 2017 |
| SIRT2 deletion enhances KRAS-induced tumorigenesis in vivo by regulating K147 acetylation status HY Song, M Biancucci, HJ Kang, C O'Callaghan, SH Park, DR Principe, ... Oncotarget 7 (49), 80336, 2016 | 37 | 2016 |
| Mitogen-activated protein kinase inhibitors and T-cell-dependent immunotherapy in cancer S Kumar, DR Principe, SK Singh, N Viswakarma, G Sondarva, B Rana, ... Pharmaceuticals 13 (1), 9, 2020 | 36 | 2020 |
| Interplay between interferon regulatory factor 1 and BRD4 in the regulation of PD-L1 in pancreatic stellate cells K Ebine, K Kumar, TN Pham, MA Shields, KA Collier, M Shang, ... Scientific reports 8 (1), 13225, 2018 | 36 | 2018 |
| KRASG12D and TP53R167H Cooperate to Induce Pancreatic Ductal Adenocarcinoma in Sus scrofa Pigs DR Principe, NH Overgaard, AJ Park, AM Diaz, C Torres, R McKinney, ... Scientific reports 8 (1), 12548, 2018 | 34 | 2018 |
