Lawrence P. Kane
Lawrence P. Kane
Professor of Immunology, University of Pittsburgh
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Cited by
Cited by
Induction of NF-κB by the Akt/PKB kinase
LP Kane, VS Shapiro, D Stokoe, A Weiss
Current Biology 9 (11), S1, 1999
Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells
AC Anderson, DE Anderson, L Bregoli, WD Hastings, N Kassam, C Lei, ...
Science 318 (5853), 1141-1143, 2007
Signal transduction by the TCR for antigen
LP Kane, J Lin, A Weiss
Current opinion in immunology 12 (3), 242-249, 2000
Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-γ but not TH2 cytokines
LP Kane, PG Andres, KC Howland, AK Abbas, A Weiss
Nature immunology 2 (1), 37-44, 2001
The PI‐3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP3
LP Kane, A Weiss
Immunological reviews 192 (1), 7-20, 2003
Phosphotyrosine-dependent coupling of Tim-3 to T-cell receptor signaling pathways
J Lee, EW Su, C Zhu, S Hainline, J Phuah, JA Moroco, TE Smithgall, ...
Molecular and cellular biology 31 (19), 3963-3974, 2011
Adaptive resistance to anti-PD1 therapy by Tim-3 upregulation is mediated by the PI3K-Akt pathway in head and neck cancer
G Shayan, R Srivastava, J Li, N Schmitt, LP Kane, RL Ferris
Oncoimmunology 6 (1), e1261779, 2017
It's all Rel-ative: NF-κB and CD28 costimulation of T-cell activation
LP Kane, J Lin, A Weiss
Trends in immunology 23 (8), 413-420, 2002
TIM-3 as a Target for Cancer Immunotherapy and Mechanisms of Action
W Du, M Yang, A Turner, C Xu, RL Ferris, J Huang, LP Kane, B Lu
International journal of molecular sciences 18 (3), 645, 2017
PD-1/SHP-2 inhibits Tc1/Th1 phenotypic responses and the activation of T cells in the tumor microenvironment
J Li, HB Jie, Y Lei, N Gildener-Leapman, S Trivedi, T Green, LP Kane, ...
Cancer research 75 (3), 508-518, 2015
Too much of a good thing? Tim-3 and TCR signaling in T cell exhaustion
RL Ferris, B Lu, LP Kane
The Journal of Immunology 193 (4), 1525-1530, 2014
Dominant role of antigen dose in CD4+ Foxp3+ regulatory T cell induction and expansion
MS Turner, LP Kane, PA Morel
The Journal of Immunology 183 (8), 4895-4903, 2009
Akt-dependent phosphorylation specifically regulates Cot induction of NF-κB-dependent transcription
LP Kane, MN Mollenauer, Z Xu, CW Turck, A Weiss
Molecular and cellular biology 22 (16), 5962-5974, 2002
Two signals are required for negative selection of CD4+ CD8+ thymocytes.
DM Page, LP Kane, JP Allison, SM Hedrick
Journal of immunology (Baltimore, Md.: 1950) 151 (4), 1868-1880, 1993
T cell Ig and mucin 1 (TIM-1) is expressed on in vivo-activated T cells and provides a costimulatory signal for T cell activation
AJ de Souza, TB Oriss, KJ O'malley, A Ray, LP Kane
Proceedings of the National Academy of Sciences 102 (47), 17113-17118, 2005
Oral epithelial cells orchestrate innate type 17 responses to Candida albicans through the virulence factor candidalysin
AH Verma, JP Richardson, C Zhou, BM Coleman, DL Moyes, J Ho, ...
Science immunology 2 (17), eaam8834, 2017
Disruption of Akt kinase activation is important for immunosuppression induced by measles virus
E Avota, A Avots, S Niewiesk, LP Kane, U Bommhardt, V ter Meulen, ...
Nature medicine 7 (6), 725-731, 2001
A Nck-Pak1 signaling module is required for T-cell receptor-mediated activation of NFAT, but not of JNK
D Yablonski, LP Kane, D Qian, A Weiss
The EMBO journal 17 (19), 5647-5657, 1998
Tim-3 co-stimulation promotes short-lived effector T cells, restricts memory precursors, and is dispensable for T cell exhaustion
L Avery, J Filderman, AL Szymczak-Workman, LP Kane
Proceedings of the national academy of sciences 115 (10), 2455-2460, 2018
IL-17RC is required for immune signaling via an extended SEF/IL-17R signaling domain in the cytoplasmic tail
AW Ho, F Shen, HR Conti, N Patel, EE Childs, AC Peterson, ...
The Journal of Immunology 185 (2), 1063-1070, 2010
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