| Evaluation of Ebola virus inhibitors for drug repurposing PB Madrid, RG Panchal, TK Warren, AC Shurtleff, AN Endsley, CE Green, ... ACS infectious diseases 1 (7), 317-326, 2015 | 281 | 2015 |
| A systematic screen of FDA-approved drugs for inhibitors of biological threat agents PB Madrid, S Chopra, ID Manger, L Gilfillan, TR Keepers, AC Shurtleff, ... PloS one 8 (4), e60579, 2013 | 278 | 2013 |
| Synthesis of ring-substituted 4-aminoquinolines and evaluation of their antimalarial activities PB Madrid, J Sherrill, AP Liou, JL Weisman, JL DeRisi, RK Guy Bioorganic & medicinal chemistry letters 15 (4), 1015-1018, 2005 | 189 | 2005 |
| Activity of piperaquine and other 4-aminoquinoline antiplasmodial drugs against chloroquine-sensitive and resistant blood-stages of Plasmodium falciparum: role of β-haematin … DC Warhurst, JC Craig, IS Adagu, RK Guy, PB Madrid, QL Fivelman Biochemical pharmacology 73 (12), 1910-1926, 2007 | 122 | 2007 |
| Evaluation of gyrase B as a drug target in Mycobacterium tuberculosis S Chopra, K Matsuyama, T Tran, JP Malerich, B Wan, SG Franzblau, ... Journal of antimicrobial chemotherapy 67 (2), 415-421, 2012 | 114 | 2012 |
| Incorporation of an Intramolecular Hydrogen-Bonding Motif in the Side Chain of 4-Aminoquinolines Enhances Activity against Drug-Resistant P. falciparum PB Madrid, AP Liou, JL DeRisi, RK Guy Journal of medicinal chemistry 49 (15), 4535-4543, 2006 | 112 | 2006 |
| Parallel synthesis of 9-aminoacridines and their evaluation against chloroquine-resistant Plasmodium falciparum MO Anderson, J Sherrill, PB Madrid, AP Liou, JL Weisman, JL DeRisi, ... Bioorganic & medicinal chemistry 14 (2), 334-343, 2006 | 108 | 2006 |
| The Natural Product Eugenol Is an Inhibitor of the Ebola Virus In Vitro T Lane, M Anantpadma, JS Freundlich, RA Davey, PB Madrid, S Ekins Pharmaceutical research 36, 1-6, 2019 | 107 | 2019 |
| Synthesis and antitubercular activity of phenothiazines with reduced binding to dopamine and serotonin receptors PB Madrid, WE Polgar, L Toll, MJ Tanga Bioorganic & medicinal chemistry letters 17 (11), 3014-3017, 2007 | 96 | 2007 |
| Machine learning models identify molecules active against the Ebola virus in vitro S Ekins, JS Freundlich, AM Clark, M Anantpadma, RA Davey, P Madrid F1000Research 4, 2015 | 95 | 2015 |
| Parallel synthesis and antimalarial screening of a 4-aminoquinoline library PB Madrid, NT Wilson, JL DeRisi, RK Guy Journal of combinatorial chemistry 6 (3), 437-442, 2004 | 90 | 2004 |
| Identification of antimicrobial activity among FDA-approved drugs for combating Mycobacterium abscessus and Mycobacterium chelonae S Chopra, K Matsuyama, C Hutson, P Madrid Journal of Antimicrobial Chemotherapy 66 (7), 1533-1536, 2011 | 89 | 2011 |
| Synthesis and testing of a focused phenothiazine library for binding to HIV-1 TAR RNA M Mayer, PT Lang, S Gerber, PB Madrid, IG Pinto, RK Guy, TL James Chemistry & biology 13 (9), 993-1000, 2006 | 86 | 2006 |
| Acylideneoxoindoles: a new class of reversible inhibitors of human transglutaminase 2 C Klöck, X Jin, K Choi, C Khosla, PB Madrid, A Spencer, BC Raimundo, ... Bioorganic & medicinal chemistry letters 21 (9), 2692-2696, 2011 | 82 | 2011 |
| Repurposing the Ebola and Marburg Virus Inhibitors Tilorone, Quinacrine, and Pyronaridine: In Vitro Activity against SARS-CoV-2 and Potential Mechanisms AC Puhl, EJ Fritch, TR Lane, LV Tse, BL Yount, CQ Sacramento, ... ACS omega 6 (11), 7454-7468, 2021 | 72 | 2021 |
| Development of a new generation of 4-aminoquinoline antimalarial compounds using predictive pharmacokinetic and toxicology models S Ray, PB Madrid, P Catz, SE LeValley, MJ Furniss, LL Rausch, RK Guy, ... Journal of medicinal chemistry 53 (9), 3685-3695, 2010 | 70 | 2010 |
| Fully automated chemical synthesis: toward the universal synthesizer N Collins, D Stout, JP Lim, JP Malerich, JD White, PB Madrid, ... Organic Process Research & Development 24 (10), 2064-2077, 2020 | 68 | 2020 |
| Repurposing FDA-approved drugs to combat drug-resistant Acinetobacter baumannii S Chopra, M Torres-Ortiz, L Hokama, P Madrid, M Tanga, K Mortelmans, ... Journal of antimicrobial chemotherapy 65 (12), 2598-2601, 2010 | 68 | 2010 |
| Efficacy of tilorone dihydrochloride against Ebola virus infection S Ekins, MA Lingerfelt, JE Comer, AN Freiberg, JC Mirsalis, K O'Loughlin, ... Antimicrobial agents and chemotherapy 62 (2), 10.1128/aac. 01711-17, 2018 | 67 | 2018 |
| SU11248 (sunitinib) directly inhibits the activity of mammalian 5'-AMP-activated protein kinase (AMPK) K Laderoute, JM Calaoagan, PB Madrid, AE Klon, PJ Ehrlich Cancer biology & therapy 10 (1), 68-76, 2010 | 63 | 2010 |
